Active Recombinant Human OLIG2, GST-tagged

• Cat.No.: OLIG2-28318TH
• Product Overview: Human OLIG2 full-length ORF ( AAH36245.1, 1 a.a. - 323 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
• Source: wheat germ
• Species: Human
• Tag: GST
• Form: Liquid
• Bio-activity: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using murine NR6R/3T3 cells is less than 1.8 ng/ml, corresponding to a specific activity of ＞ 5.6 × 10~5 IU/mg
• Molecular Mass: 58.8 kDa
• AA Sequence: MDSDASLVSSRPSSPEPDDLFLPAR SKGSSGSAFTGGTVSSSTPSDCPPE LSAELRGAMGSAGAHPVDKLGGSGF KSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRERKRMHDLN IAMDGLREVMPYAHGPSVRKLSKIA TLLLARNYILMLTNSLEEMKRLVSE IYGGHHAGFHPSACGGLAHSAPLPA ATAHPAAAAHAAHHPAVHHPILPPA AAAAAAAAAAAAVSSASLPGSGLPS VGSIRPPHGLLKSPSAAAAAPLGGG GGGSGASGGFQHWGGMPCPCSMCQV PPPHHHVSAMGAGSLPRLTSDAK
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: OLIG2 oligodendrocyte lineage transcription factor 2 [ Homo sapiens ]
• Official Symbol: OLIG2
• Synonyms: OLIG2; oligodendrocyte lineage transcription factor 2; oligodendrocyte transcription factor 2; protein kinase C-binding protein 2; class B basic helix-loop-helix protein 1; class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; basic domain, helix-loop-helix protein, class B, 1; oligodendrocyte-specific bHLH transcription factor 2; BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
• Gene ID: 10215
• mRNA Refseq: NM_005806
• Protein Refseq: NP_005797
• Function: DNA binding; HMG box domain binding; protein homodimerization activity; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity

Reviews

01/24/2019

Swift protein sequencing, invaluable for protein identification.

07/05/2018

Consistent western blot results, a lab necessity for us.

05/26/2018

Great protein crystallization service, vital for structural biology studies.

Q&As

How does OLIG2 (Oligodendrocyte Transcription Factor 2) regulate the development and maturation of oligodendrocytes?

OLIG2 is essential for the development and maturation of oligodendrocytes, which form myelin in the nervous system.

What is the impact of OLIG2 on the pathogenesis of gliomas and other brain tumors?

OLIG2 is implicated in the development of gliomas, influencing tumor cell differentiation and growth.

What role does OLIG2 play in neural stem cell differentiation, particularly in the central nervous system?

OLIG2 plays a crucial role in directing neural stem cells to differentiate into oligodendrocytes and neurons in the CNS.

How does OLIG2 influence neuronal and glial cell interactions during brain development?

OLIG2 affects interactions between neurons and glial cells, essential for proper brain development.

How do alterations in OLIG2 expression or function affect neurodevelopmental disorders?

Changes in OLIG2 can lead to neurodevelopmental disorders due to altered brain cell development and function.

How does OLIG2 contribute to the repair and regeneration of myelin in demyelinating diseases?

OLIG2 contributes to myelin repair and regeneration, crucial in demyelinating diseases like multiple sclerosis.

What are the mechanisms by which OLIG2 modulates gene expression in neurodevelopmental processes?

OLIG2 modulates gene expression, guiding key neurodevelopmental processes and cell fate decisions.