Active Recombinant Full Length Human OLIG2 Protein, GST-tagged

• Cat.No.: OLIG2-353HF
• Product Overview: Human OLIG2 full-length ORF ( AAH36245.1, 1 a.a. - 323 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Form: Liquid
• Bio-activity: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using murine NR6R/3T3 cells is less than 1.8 ng/ml, corresponding to a specific activity of ＞ 5.6 × 10~5 IU/mg
• Molecular Mass: 58.8 kDa
• Protein Length: 1 a.a. - 323 a.a.
• AA Sequence: MDSDASLVSS RPSSPEPDDL FLPARSKGSS GSAFTGGTVS SSTPSDCPPE LSAELRGAMG SAGAHPVDKL GGSGFKSSSS STSSSTSSAA ASSTKKDKKQ MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSAPLPA ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLPS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG ASGGFQHWGG MPCPCSMCQV PPPHHHVSAM GAGSLPRLTS DAK
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: OLIG2 oligodendrocyte lineage transcription factor 2 [ Homo sapiens ]
• Official Symbol: OLIG2
• Synonyms: OLIG2; oligodendrocyte lineage transcription factor 2; oligodendrocyte transcription factor 2; protein kinase C-binding protein 2; class B basic helix-loop-helix protein 1; class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; basic domain, helix-loop-helix protein, class B, 1; oligodendrocyte-specific bHLH transcription factor 2; BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
• Gene ID: 10215
• mRNA Refseq: NM_005806
• Protein Refseq: NP_005797
• MIM: 606386
• UniProt ID: Q13516