• Official Full Name

    proprotein convertase subtilisin/kexin type 1

  • Background

    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]
  • Synonyms

    PCSK1; proprotein convertase subtilisin/kexin type 1; PC1; PC3; NEC1; SPC3; BMIQ12; neuroendocrine convertase 1; prohormone convertase 1; prohormone convertase 3;
    • Type:
    • Cell & Tissue Lysates
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Yeast
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PCSK1-2249HCL Recombinant Human PCSK1 cell lysate Human Cell N/A
    Human PCSK1-764H Recombinant Human PCSK1 Protein, His-tagged E.coli His
    Human PCSK1-3808H-B Recombinant Human PCSK1 Protein Pre-coupled Magnetic Beads HEK293
    Human PCSK1-180H Active Recombinant Human PCSK1, His-tagged HEK293 His
    Human PCSK1-892H Recombinant Human PCSK1 protein, His-tagged HEK293 His
    Human PCSK1-3808H Recombinant Human PCSK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human PCSK1-87H Active Recombinant Human PCSK1, His-tagged Mammalian cells His
    Human PCSK1-3752H Recombinant Human PCSK1 protein, GST-tagged E.coli GST
    Mouse Pcsk1-1157M Recombinant Mouse Pcsk1 protein, His & T7-tagged E.coli His/T7
    Mouse PCSK1-6562M Recombinant Mouse PCSK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse PCSK1-6562M-B Recombinant Mouse PCSK1 Protein Pre-coupled Magnetic Beads HEK293
    Mouse PCSK1-12513M Recombinant Mouse PCSK1 Protein Mammalian Cell His
    Rat PCSK1-2091R Recombinant Rat PCSK1 Protein (111-752 aa), His-tagged Yeast His
    Rat PCSK1-4305R Recombinant Rat Pcsk1 protein, His-tagged HEK293 His
    Zebrafish PCSK1-7222Z Recombinant Zebrafish PCSK1 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • PCSK1 Related Articles
    • PCSK1 Related Research Area

    PCSK1 involved in several pathways and played different roles in them. We selected most pathways PCSK1 participated on our site, such as Incretin synthesis, secretion, and inactivation, Insulin processing, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Incretin synthesis, secretion, and inactivationGPR119;PCSK1;GRP;GPR120;SPCS3;CDX2;DPP4;SLC38A8;O3far1
    Insulin processingRAB27A;SLC30A6;KIF5B;KIF5A;EXOC1;CPE;PCSK2;CPN1;EXOC5
    Metabolism of proteinsSCMH1;FBXW2;C8orf84;O3far1;NSMCE1;ADAMTS15;GALNT6;PPP6C;DNAJC24
    Peptide hormone biosynthesisCGB7;CGB5;INHBAA;INHA;PCSK1
    Peptide hormone metabolismINHA;GPR119;CGB7;SLC38A8;CPE;GRP;SLC30A6;GPR120;SLC30A5
    Synthesis, secretion, and deacylation of GhrelinMBOAT4;SLC38A8;SPCS3;PCSK1
    Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)GPR119;DPP4;PCSK1

    PCSK1 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK1 itself. We selected most functions PCSK1 had, and list some proteins which have the same functions with PCSK1. You can find most of the proteins on our site.

    Function Related Protein
    serine-type endopeptidase activityC1S;MCPT8;CMA1;HTRA2;PRSS3;PRSS58;ELA2L;PCSK6;GZMC

    PCSK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK1.

    Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
    de Keyser, CE; Becker, ML; et al. The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels. PHARMACOGENETICS AND GENOMICS 25:134-142(2015).
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