PCSK1 involved in several pathways and played different roles in them. We selected most pathways PCSK1 participated on our site, such as Incretin synthesis, secretion, and inactivation, Insulin processing, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Incretin synthesis, secretion, and inactivation |
DPP4; SLC38A8; CDX2; GPR120; PCSK1; GRP; GPR119; O3far1; SPCS3 |
| Insulin processing |
PCSK1; RAB27A; SLC30A5; EXOC5; KIF5B; SLC30A6; CPE; EXOC6; EXOC1; EXOC8 |
| Metabolism of proteins |
DPH5; RHBDL1; APCS; DDOST; KLHDC3; TIMM17A; SMC6; NSFA; ARL2; PAM16 |
| Peptide hormone biosynthesis |
CGB7; PCSK1; CGB5; INHBAA; INHA |
| Peptide hormone metabolism |
CMA1; CGB5; ATP6AP2; GZMH; SLC30A6; GPR120; EXOC8; SPCS3; CGB7; CPN1 |
| Synthesis, secretion, and deacylation of Ghrelin |
SLC38A8; SPCS3; PCSK1; MBOAT4 |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
GPR119; PCSK1; DPP4 |
PCSK1 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK1 itself. We selected most functions PCSK1 had, and list some proteins which have the same functions with PCSK1. You can find most of the proteins on our site.
| Function |
Related Protein |
| serine-type endopeptidase activity |
PIK3IP1; CTSG; TMPRSS12; F7; TMPRSS11F; HGF; MASP1; F9; HPN; TMPRSS11B |
PCSK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK1.
Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
de Keyser, CE; Becker, ML; et al. The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels. PHARMACOGENETICS AND GENOMICS 25:134-142(2015).
