PCSK1-87H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Human PCSK1 (Ser111-Arg617) fused with 10His tag at Cterminal, was expressed in Mouse NSO Cells.
Description :
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
Source :
Mammalian cells
Species :
Human
Tag :
His
Predicted N Terminal :
Ser111
Form :
Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.
Bio-activity :
Measured by its ability to cleave a fluorogenic peptide substrate, acetyl-Arg-Glu-Lys-Arg-7-amino-trifluoromethyl coumarin (Ac-REKR-AFC). The specific activity is >8 pmol/min/µg, as measured under the described conditions.
< 1.0 EU per 1 μg of the protein by the LAL method.
Purity :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.