Active Recombinant Human PCSK1, His-tagged

Cat.No. : PCSK1-87H
Product Overview : Recombinant Human PCSK1 (Ser111-Arg617) fused with 10­His tag at C­terminal, was expressed in Mouse NSO Cells.
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Description : The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Ser111
Form : Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.
Bio-activity : Measured by its ability to cleave a fluorogenic peptide substrate, acetyl-Arg-Glu-Lys-Arg-7-amino-trifluoromethyl coumarin (Ac-REKR-AFC). The specific activity is >8 pmol/min/µg, as measured under the described conditions.
Molecular Mass : Predicted Molecular Mass: 57 kDa; SDS-PAGE:66 kDa, reducing conditions.
Endotoxin : < 1.0 EU per 1 μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
Gene Name : PCSK1 proprotein convertase subtilisin/kexin type 1 [ Homo sapiens(human) ]
Official Symbol : PCSK1
Synonyms : PCSK1; PC1; PC3; NEC1; SPC3; BMIQ12; proprotein convertase subtilisin/kexin type 1; neuroendocrine convertase 1; NEC 1; prohormone convertase 1; prohormone convertase 3; EC 3.4.21.93
Gene ID : 5122
mRNA Refseq : NM_000439
Protein Refseq : NP_000430
MIM : 162150
UniProt ID : P29120
Chromosome Location : 5q15-q21
Pathway : Incretin Synthesis; Insulin Processing; Peptide hormone biosynthesis
Function : serine-type endopeptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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