Prlr

What is PRLR Protein?

PRLR, short for Prolactin Receptor, is a type of cytokine receptor that mainly operates through the JAK-STAT signaling pathway. It's key to a bunch of body functions like milk production, reproduction, making pancreas cells, managing fat cells, and keeping the immune system in check. When prolactin hooks up with PRLR, it kicks off different signaling activities, and if these get messed up, it could lead to things like cancer, reproductive issues, and diabetes. Plus, prolactin isn't just a pituitary thing; it can pop up elsewhere, making its role in the body pretty complex. The PRLR protein is consisted of 622 amino acids and PRLR molecular weight is approximately 69.5 kDa.

What is the Function of PRLR Protein?

PRLR, short for Prolactin Receptor, is like a key player in our body that takes part in numerous essential activities. Think of it as a special type of receptor that mainly communicates through a pathway known as JAK-STAT. This receptor is important for a bunch of bodily processes like helping with milk production during breastfeeding, aiding in reproduction, supporting the development of cells in the pancreas, regulating fat cells, and even keeping our immune system in check. When the hormone prolactin hooks up with PRLR, it triggers these processes. If something messes up this system, it can lead to issues such as tumors, problems with having kids, or diabetes. Interestingly, prolactin isn't just limited to being produced in the pituitary gland; it can be found in other parts of the body, which only makes its role more complicated and fascinating.

Fig1. Transcriptional regulation of hPRLR induced by E2. (Raghuveer Kavarthapu, 2022)

PRLR Related Signaling Pathway

PRLR, short for Prolactin Receptor, is a protein that mainly gets things moving through something called the JAK-STAT pathway. Think of it as a messenger that prolactin, a kind of hormone, latches onto so it can send important signals around the body. This whole setup is crucial for loads of body functions like making milk, having babies, managing body fat, and even fighting off germs. If this signaling goes sideways, it might lead to problems like tumors, issues with having kids, or diabetes. And to make things a bit more complicated, prolactin isn't just hanging out in the pituitary gland; it can pop up in other places too, messing with how it all works.

PRLR Related Diseases

Prolactin receptor (PRLR) is connected to several health issues that might not be so obvious at first glance. When the signaling pathways involving PRLR and its partner, prolactin, get disrupted, it can lead to troubles like cancer, problems with reproduction, and even conditions like diabetes. Prolactin isn't just produced in the pituitary gland; it can pop up in different places, adding a layer of complexity to how it functions in the body. So, when these pathways go off course, it can show up in different forms, highlighting how key PRLR is in keeping things in balance.

Bioapplications of PRLR

Recombinant PRLR protein's got some real-world uses in research and industry. Scientists often dive into its role in various diseases, which helps in figuring out treatments. In labs, this protein is a key player for studying hormone interactions and signaling pathways. It's like having a hands-on tool to understand complex biological processes better. Meanwhile, in the biotech field, PRLR can be used to develop new therapeutic drugs or diagnostic tools. So, whether it's helping to unravel the mysteries of diseases or aiding in the development of next-gen medical solutions, PRLR is pretty versatile and valuable in these areas.