Active Recombinant Human PTPN11 Protein(Full length), N-GST-tagged

• Cat.No.: PTPN11-04H
• Product Overview: Recombinant full-length human PTPN11 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 1-593 a.a.
• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
• Bio-activity: 7,800 nmol/min/mg
• Molecular Mass: 98 kDa
• Purity: The purity was determined to be > 90% by densitometry.
• Applications: Phosphatase Assay, Western Blot
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: Recombinant protein stored in 20 mM MOPS, pH 7.5, 300 mM NaCI, 10 mM glutathione, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Gene Information

• Gene Name: PTPN11 protein tyrosine phosphatase non-receptor type 11 [ Homo sapiens (human) ]
• Official Symbol: PTPN11
• Synonyms: PTPN11; protein tyrosine phosphatase non-receptor type 11; CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3; tyrosine-protein phosphatase non-receptor type 11; SH2 domain-containing protein tyrosine phosphatase 2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; EC 3.1.3.48
• Gene ID: 5781
• mRNA Refseq: NM_002834
• Protein Refseq: NP_002825
• MIM: 176876
• UniProt ID: Q06124