| Official Full Name | ribosomal protein S6 kinase, 70kDa, polypeptide 1 |
| Background | p70S6K is responsible for the phosphorylation of 40Sribosomal protein S6, and is ubiquitously expressed inhuman adult tissues (1). p70S6K is activated by serumstimulation and this activation is inhibited by wortmanninand rapamycin. p70S6k activity changes during the cellcycle, and increases 20-fold in G1 cells released from G0(2). p70S6K activation requires sequential phosphorylationat proline-directed residues in the putative autoinhibitorypseudosubstrate domain, as well as threonine 389, a sitephosphorylated by phosphoinositide-dependent kinase 1(PDK-1). |
| Synonyms | RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, 70kD, polypeptide 1 , STK14A; ribosomal protein S6 kinase beta-1; p70(S6K) alpha; PS6K; S6K1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1; S6K; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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RPS6KB1 involved in several pathways and played different roles in them. We selected most pathways RPS6KB1 participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | HBEGFB; MAPK9; MAP2K4B; CAMK2D2; ERBB3A; NRG2B; PTK2; MAP2K7; ERBB4A; EREG |
| HIF- signaling pathway | HK1; IL6; CUL2; PIK3R1; PRKCB; PFKL; PFKFB3; PIK3R2; IFNGR2; ENO2 |
| mTOR signaling pathway | IRS1; EIF4BB; AKT2; PTENA; AKT2L; EIF4E2; PIK3R2; IGF1; TNF; PIK3CG |
| PIK-Akt signaling pathway | PIK3R5; ITGB1; MAPK3; THBS4; IGF1R; GNG12; GNG2; IL4R; AKT2; PDGFRA |
| AMPK signaling pathway | PPP2R2B; PRKAB1; GYS1; ELAVL1; RAB10; PFKFB3; SIRT1; PPP2R2A; G6PC3; CAMKK1 |
| TGF-beta signaling pathway | SMAD1; ACVR1B; ROCK1; BMPR1BB; FSTA; TGFB1A; RHOAB; BMPR2; BMPR1B; NOG |
| Fc gamma R-mediated phagocytosis | PAK1; LIMK2; PLA2G4D; PRKCD; ARPC5L; VASP; PIK3CB; MAPK1; PIK3R1; PIK3CD |
| Insulin signaling pathway | FOXO1; PRKACBB; SOCS4; MAPK1; MKNK2; SOCS1A; TRIP10; CALM3; HKDC1; RAF1 |
| Insulin resistance | NOS3; RPS6KA1; PTENA; AKT2L; PRKCQ; PRKAB1B; PPP1R3CB; INSRA; PCK2; CRTC2 |
| Proteoglycans in cancer | ERBB4; ELK1; DDX5; RRAS2; DROSHA; ANK1; RPS6; HGF; PAK1; MAPK11 |
| Acute myeloid leukemia | SPI1; IKBKG; NFKB1; CCND1; LEF1; CCNA1; TCF7L2; PIK3R1; PIK3R2; STAT5B |
| Choline metabolism in cancer | PPAP2A; PIK3R2; SLC5A7; WAS; PLA2G4D; PDGFC; PPAP2C; PDGFB; MAP2K1; TSC2 |
RPS6KB1 has several biochemical functions, for example, ATP binding, peptide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KB1 itself. We selected most functions RPS6KB1 had, and list some proteins which have the same functions with RPS6KB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TTL; AURKB; DHX58; UBE2O; FBXO18; NADK; VRK3; RIPK2; FIGN; CDK16 |
| peptide binding | PPYR1; NPFFR1; ANPEPA; H2-Q10; AVPR1A; GNRHR; ERAP1; NLN; NPFFR2.1; THOP1 |
| protein binding | HDAC7A; BMP1; CYB5R1; MUC5B; SOCS4; SNAP91; ITGA1; FAM206A; USHBP1; PAIP1 |
| protein kinase activity | EEF2K; SNRKA; PRKACBA; MMD2; PAK4; MAP3K10; CCL2; STK25B; STK24B; DYRK3 |
| protein phosphatase 2A binding | FOXO1; SPHK1; MASTL; CPD; AKT1; PPME1; SHC1; ENSA; TRP53; ENSAA |
| protein serine/threonine/tyrosine kinase activity | DYRK2; PRKAA2; ACVR2B; TESK2; DYRK1AA; DYRK3; PRKCG; AKT1; DYRK1B; DYRK1A |
| ribosomal protein S6 kinase activity | RPS6KB1; RPS6KA6; ALPK2; RPS6KA4; RPS6KA2; RPS6KA1; RPS6KB2; RPS6KA3B; RPS6KA3; RPS6KB1B |
RPS6KB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KB1.
AKT1; EIF3B; COASY; PPP2R2B; MAPT; MAPT; PDK1; GLI1; HSP90AB1; STK11
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