RPS6KB1 Protein


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Official Full Name ribosomal protein S6 kinase, 70kDa, polypeptide 1
Background p70S6K is responsible for the phosphorylation of 40Sribosomal protein S6, and is ubiquitously expressed inhuman adult tissues (1). p70S6K is activated by serumstimulation and this activation is inhibited by wortmanninand rapamycin. p70S6k activity changes during the cellcycle, and increases 20-fold in G1 cells released from G0(2). p70S6K activation requires sequential phosphorylationat proline-directed residues in the putative autoinhibitorypseudosubstrate domain, as well as threonine 389, a sitephosphorylated by phosphoinositide-dependent kinase 1(PDK-1).
Synonyms RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, 70kD, polypeptide 1 , STK14A; ribosomal protein S6 kinase beta-1; p70(S6K) alpha; PS6K; S6K1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1; S6K; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RPS6KB1-001HCL Recombinant Human RPS6KB1 cell lysate Insect Cell N/A
    Human RPS6KB1-13H Recombinant Human RPS6KB1 Protein, His-tagged E.coli His
    Human RPS6KB1-195H Recombinant Human RPS6KB1, GST-tagged Sf9 Insect Cell GST
    Human RPS6KB1-23H Recombinant Human RPS6KB1 protein, His-tagged, Unactive Insect Cell His
    Human RPS6KB1-29261TH Recombinant Human RPS6KB1, His-tagged E.coli His
    Human RPS6KB1-31345TH Recombinant Human RPS6KB1, His-tagged His
    Human RPS6KB1-3720H Recombinant Human RPS6KB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human RPS6KB1-376H Recombinant Human RPS6KB1, His-tagged, Active Sf9 Insect Cell His
    Human RPS6KB1-5478H Recombinant Human Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1, GST-tagged Insect Cell GST
    Human RPS6KB1-556H Recombinant Human RPS6KB1, His-tagged Sf9 Insect Cell His
    Human RPS6KB1-560H Recombinant Human RPS6KB1, GST-tagged Sf9 Insect Cell GST
    Human RPS6KB1-8524H Recombinant Human RPS6KB1, GST tagged Insect Cell GST
    Mouse Rps6kb1-5613M Recombinant Mouse Rps6kb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Rps6kb1-143R Recombinant Rat Rps6kb1(T412E), His-tagged Insect Cell His
    Rat RPS6KB1-5173R Recombinant Rat RPS6KB1 Protein Mammalian Cell His
    Chicken RPS6KB1-2422C Recombinant Chicken RPS6KB1 Mammalian Cell His

    RPS6KB1 involved in several pathways and played different roles in them. We selected most pathways RPS6KB1 participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway HBEGFB; MAPK9; MAP2K4B; CAMK2D2; ERBB3A; NRG2B; PTK2; MAP2K7; ERBB4A; EREG
    HIF- signaling pathway HK1; IL6; CUL2; PIK3R1; PRKCB; PFKL; PFKFB3; PIK3R2; IFNGR2; ENO2
    mTOR signaling pathway IRS1; EIF4BB; AKT2; PTENA; AKT2L; EIF4E2; PIK3R2; IGF1; TNF; PIK3CG
    PIK-Akt signaling pathway PIK3R5; ITGB1; MAPK3; THBS4; IGF1R; GNG12; GNG2; IL4R; AKT2; PDGFRA
    AMPK signaling pathway PPP2R2B; PRKAB1; GYS1; ELAVL1; RAB10; PFKFB3; SIRT1; PPP2R2A; G6PC3; CAMKK1
    TGF-beta signaling pathway SMAD1; ACVR1B; ROCK1; BMPR1BB; FSTA; TGFB1A; RHOAB; BMPR2; BMPR1B; NOG
    Fc gamma R-mediated phagocytosis PAK1; LIMK2; PLA2G4D; PRKCD; ARPC5L; VASP; PIK3CB; MAPK1; PIK3R1; PIK3CD
    Insulin signaling pathway FOXO1; PRKACBB; SOCS4; MAPK1; MKNK2; SOCS1A; TRIP10; CALM3; HKDC1; RAF1
    Insulin resistance NOS3; RPS6KA1; PTENA; AKT2L; PRKCQ; PRKAB1B; PPP1R3CB; INSRA; PCK2; CRTC2
    Proteoglycans in cancer ERBB4; ELK1; DDX5; RRAS2; DROSHA; ANK1; RPS6; HGF; PAK1; MAPK11
    Acute myeloid leukemia SPI1; IKBKG; NFKB1; CCND1; LEF1; CCNA1; TCF7L2; PIK3R1; PIK3R2; STAT5B
    Choline metabolism in cancer PPAP2A; PIK3R2; SLC5A7; WAS; PLA2G4D; PDGFC; PPAP2C; PDGFB; MAP2K1; TSC2

    RPS6KB1 has several biochemical functions, for example, ATP binding, peptide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KB1 itself. We selected most functions RPS6KB1 had, and list some proteins which have the same functions with RPS6KB1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TTL; AURKB; DHX58; UBE2O; FBXO18; NADK; VRK3; RIPK2; FIGN; CDK16
    peptide binding PPYR1; NPFFR1; ANPEPA; H2-Q10; AVPR1A; GNRHR; ERAP1; NLN; NPFFR2.1; THOP1
    protein binding HDAC7A; BMP1; CYB5R1; MUC5B; SOCS4; SNAP91; ITGA1; FAM206A; USHBP1; PAIP1
    protein kinase activity EEF2K; SNRKA; PRKACBA; MMD2; PAK4; MAP3K10; CCL2; STK25B; STK24B; DYRK3
    protein phosphatase 2A binding FOXO1; SPHK1; MASTL; CPD; AKT1; PPME1; SHC1; ENSA; TRP53; ENSAA
    protein serine/threonine/tyrosine kinase activity DYRK2; PRKAA2; ACVR2B; TESK2; DYRK1AA; DYRK3; PRKCG; AKT1; DYRK1B; DYRK1A
    ribosomal protein S6 kinase activity RPS6KB1; RPS6KA6; ALPK2; RPS6KA4; RPS6KA2; RPS6KA1; RPS6KB2; RPS6KA3B; RPS6KA3; RPS6KB1B

    RPS6KB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KB1.


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