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  • Official Full Name

    ribosomal protein S6 kinase, 70kDa, polypeptide 1

  • Overview

    p70S6K is responsible for the phosphorylation of 40Sribosomal protein S6, and is ubiquitously expressed inhuman adult tissues (1). p70S6K is activated by serumstimulation and this activation is inhibited by wortmanninand rapamycin. p70S6k activity changes during the cellcycle, and increases 20-fold in G1 cells released from G0(2). p70S6K activation requires sequential phosphorylationat proline-directed residues in the putative autoinhibitorypseudosubstrate domain, as well as threonine 389, a sitephosphorylated by phosphoinositide-dependent kinase 1(PDK-1).
  • Synonyms

    RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, 70kD, polypeptide 1 , STK14A; ribosomal protein S6 kinase beta-1; p70(S6K) alpha; PS6K; S6K1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1; S6K; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS6KB1-556H Active Recombinant Human RPS6KB1, His-tagged Sf9 Insect Cell His
Human RPS6KB1-177H Active Recombinant Human RPS6KB1(1-421) Protein, N-His-tagged Sf21 His 1-421 aa
Human RPS6KB1-8524H Recombinant Human RPS6KB1 protein(Met1-Leu525), GST-tagged Insect Cells N-GST Met1-Leu525
Human RPS6KB1-31345TH Recombinant Human RPS6KB1, His-tagged His
Human RPS6KB1-23H Recombinant Human RPS6KB1 protein, His-tagged, Unactive Insect Cell His
Human RPS6KB1-13H Recombinant Human RPS6KB1 Protein, His-tagged E.coli His Phe91~Phe352
Human RPS6KB1-560H Recombinant Human RPS6KB1, GST-tagged Sf9 Insect Cell GST
Human RPS6KB1-376H Recombinant Human RPS6KB1, His-tagged, Active Sf9 Insect Cell His
Human RPS6KB1-29261TH Recombinant Human RPS6KB1, His-tagged E.coli His
Human RPS6KB1-195H Recombinant Human RPS6KB1, GST-tagged Sf9 Insect Cell GST
Human RPS6KB1-5478H Recombinant Human Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1, GST-tagged Insect Cell GST
Human RPS6KB1-001HCL Recombinant Human RPS6KB1 cell lysate Insect Cell N/A
Human RPS6KB1-3720H Recombinant Human RPS6KB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RPS6KB1-1915H Recombinant Human RPS6KB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RPS6KB1-233HFL Active Recombinant Full Length Human RPS6KB1 Protein, C-Flag-tagged Mammalian cells Flag
Human RPS6KB1-1153H Recombinant Human RPS6KB1 Protein (R2-L525), GST tagged Insect Cell GST R2-L525
Human RPS6KB1-3185H Recombinant Human RPS6KB1 Protein (Phe91-Phe352), His tagged E.coli His Phe91-Phe352
Human RPS6KB1-1152H Recombinant Human RPS6KB1 Protein (R2-L525), Tag Free Insect Cell No tag R2-L525
Human RPS6KB1-1915H-B Recombinant Human RPS6KB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rps6kb1-5613M Recombinant Mouse Rps6kb1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Rps6kb1-143R Active Recombinant Rat Rps6kb1(T412E), His-tagged Insect Cell His
Rat RPS6KB1-5173R Recombinant Rat RPS6KB1 Protein Mammalian Cell His
Rat RPS6KB1-4832R Recombinant Rat RPS6KB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat RPS6KB1-4832R-B Recombinant Rat RPS6KB1 Protein Pre-coupled Magnetic Beads HEK293
Chicken RPS6KB1-2422C Recombinant Chicken RPS6KB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RPS6KB1 Related Research Area
  • RPS6KB1 Related Signal Pathway

RPS6KB1 involved in several pathways and played different roles in them. We selected most pathways RPS6KB1 participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayRPS6KB1;HKDC1;TF;HK1;PFKL;PGK1;NOS3;ARNT;MAPK3
PIK-Akt signaling pathwayGNG3;PRKAA1;RPS6KB2;KITLG;PKN2;PPP2R5A;GNG13;MET;GNG5
Fc gamma R-mediated phagocytosisPRKCD;ASAP1;ASAP3;GAB2;INPPL1;ARPC5L;PLA2G4F;PLCG1;WASF3
Insulin signaling pathwaySOS1;PHKG1A;TSC1;PPP1R3B;CALML5;MAPK10;RHOQ;PRKAR1AB;MAP2K2B
Proteoglycans in cancerTP53;ITGAV;PDCD4;CD63;ITPR3;MAPK3;ESR1;RRAS;MDM2
Acute myeloid leukemiaRPS6KB1;GRB2;PIK3R5;BRAF;SOS1;MYC;HRAS;RPS6KB2;MTOR
Choline metabolism in cancerPDGFD;SLC22A2;SLC44A1;PIK3CB;SLC44A2;RAC1;PLD2;PIK3R1;HRAS

RPS6KB1 has several biochemical functions, for example, ATP binding, peptide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KB1 itself. We selected most functions RPS6KB1 had, and list some proteins which have the same functions with RPS6KB1. You can find most of the proteins on our site.

Function Related Protein
protein bindingLARP4;PWWP2B;CBFA2T3;DDAH2;ZFP36L1;POLG;PEX26;COL18A1;FBXO3
protein kinase activityPAK2A;SRPK1;MAP2K4;ZNF143B;GM4922;RASSF2;IGF1RA;STK24B;PTK2BB
protein phosphatase 2A bindingARPP19;ANKLE2;PTPN1;MAPT;FOXO1;SMG7;TRP53;PPP2R2A;STRN4
protein serine/threonine/tyrosine kinase activityCLK2;CLK4;RPS6KA1;MAP2K2;ACVR2B;RPS6KB1;TTK;CLK1;AURKC
ribosomal protein S6 kinase activityRPS6KB1B;RPS6KB1;RPS6KB2;RPS6KA4;RPS6KA3;ALPK2;RPS6KA3A;RPS6KA2;RPS6KA1

RPS6KB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KB1.


  • Q&As
  • Reviews

Q&As (7)

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What are the mechanisms by which RPS6KB1 modulates autophagy and cell survival? 04/14/2022

RPS6KB1 regulates autophagy and cell survival, crucial for cellular health and response to stress.

How does RPS6KB1 (Ribosomal Protein S6 Kinase B1) regulate protein synthesis and cell growth? 02/22/2021

RPS6KB1 controls protein synthesis and cell growth, playing a key role in cellular proliferation.

What is the impact of RPS6KB1 on cellular responses to stress and DNA damage? 05/22/2020

RPS6KB1 impacts cellular stress responses, including the repair of DNA damage and maintenance of genomic stability.

How does RPS6KB1 contribute to the development and progression of cancer? 01/07/2020

RPS6KB1 can contribute to cancer by promoting tumor cell growth and proliferation.

What role does RPS6KB1 play in the mTOR signaling pathway, particularly in response to nutrient availability? 08/26/2019

RPS6KB1 is a critical component of the mTOR pathway, responding to nutrient signals to regulate cell metabolism and growth.

How do alterations in RPS6KB1 expression or activity affect aging and age-related diseases? 03/05/2019

Changes in RPS6KB1 function can affect aging processes and the development of age-related diseases.

How does RPS6KB1 influence metabolic processes, especially in conditions like obesity and diabetes? 02/13/2018

RPS6KB1 influences metabolic processes, affecting how cells respond to conditions like obesity and diabetes.

Customer Reviews (3)

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    Dependable protein purification, consistently high-quality results.


      Precise mass spectrometry analysis, essential for our proteomics work.


        Efficient peptide synthesis, crucial for our peptide research projects.

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