"RPS6KB1" Related Products

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Recombinant Human RPS6KB1 protein, His-tagged, Unactive

Cat.No.: RPS6KB1-23H
Product Overview: Recombinant Human RPS6KB1 fused with His tag at N-terminal was expressed in Insect cells.
Description: p70S6K is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues. p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6k activity undergoes changes in the cell cycle and increases 20-fold in G1 cells released from G0. p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389 a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK-1).
Source: Insect cells
Species: Human
Tag: His
Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Molecular Mass: ~76 kDa
Purity: >90%
Applications: Western Blot
Stability: 1yr at –70 centigrade from date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/ul
Gene Name: RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [ Homo sapiens ]
Official Symbol: RPS6KB1
Synonyms: RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, 70kD, polypeptide 1 , STK14A; ribosomal protein S6 kinase beta-1; p70(S6K) alpha; PS6K; S6K1; P70S6K1; p70 S6KA; S6K-beta-1; p70 S6K-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDa ribosomal protein S6 kinase 1; S6K; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha;
Gene ID: 6198
mRNA Refseq: NM_003161
Protein Refseq: NP_003152
MIM: 608938
UniProt ID: P23443
Chromosome Location: 17q23.1
Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem; Cytoplasmic Ribosomal Proteins, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem;
Function: ATP binding; nucleotide binding; peptide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity;

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