Virus-specific Antibody—New Clue to against Norovirus Infection
The picture shows its X-ray crystallographic structure
It could be said that norovirus was identified in 1972 and got its current name—norovirus in 2002 approved by ICTV .
Noroviruses (NoV), Caliciviridae family , are a genetically diverse group of single-stranded RNA, non- enveloped viruses. Noroviruses are the most common cause of viral gastroenteritis in humans, and affect people of all ages, especially very young, elderly and immuno-suppressed. Norovirus infection is characterized by nausea, forceful vomiting, watery diarrhea, and abdominal pain, and in some cases, loss of taste. According to authoritative statistics, the virus affects around 267 million people and causes over 200,000 deaths each year. Therefore, people put much energy to try to figure them out.
In last month, researchers discovered a monoclonal antibody to neutralize human norovirus. The researchers isolated the genes from chimpanzee immune cells encoding norovirus-specific antibodies. They then converted these into human-compatible full-length immunoglobulin molecules. After this, they successfully tested two effective antibodies against norovirus infection in chimpanzees. (From Journal of Virology)
Based on the findings, researchers could conduct further studies to develop virus-specific regimens or preventive vaccines to control the virus infection. “ Our working hypothesis was that a highly specific norovirus antibody that binds to the outer surface of the virus particle might prevent the ability of the virus to infect susceptible host cells”, the researchers said.