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Common Gamma-Chain Family

Creative BioMart Common Gamma-Chain Family Product List
Common Gamma-Chain Family Background

Available Resources for the Study of Common Gamma-Chain Family

At Creative BioMart, we are committed to advancing research in the field of the common gamma chain (γc) family. Our mission is to equip researchers with cutting-edge tools and knowledge related to γc family receptors and ligands.

  • We offer a diverse range of products, including recombinant proteins, pre-coupled magnetic beads, cell and tissue lysates, and more, all crucial for investigating the functions and mechanisms of the γc family.
  • Our team of experts boasts extensive experience in γc family research and is devoted to developing customized solutions to meet researchers' specific requirements.
  • Moreover, we provide comprehensive resources, such as involved pathways, protein function, interacting proteins, and other valuable information to support research endeavors and enhance their impact.

Our Featured Products

Class Cat.# Product name Species Source (Host) Tag
Common gamma Chain Family Ligands IL15-24H Recombinant Human IL15 protein Human E.coli N/A
IL2-341H Active Recombinant Human IL2 Human Human N/A
Il21-001H Active Recombinant Human Il21, HIgG1 Fc-tagged, mutant Human CHO Fc
IL7-507H Active Recombinant Human IL7, His tagged Human Human Cell His
IL7-01C Recombinant Chicken IL7 Protein, His-tagged Chicken E.coli His
IL9-14214H Recombinant Human IL9, GST-tagged Human E.coli GST
Common gamma Chain Family Receptors IL15RA-14151H Recombinant Human IL15RA protein, His-tagged Human E.coli His
IL21R-3905H Recombinant Human IL21R, His tagged Human Human Cell His
IL2RA-637H Active Recombinant Human IL2RA, His tagged Human HEK293 His
IL2RB-783H Active Recombinant Human IL2RB protein(Met1-Asp239) Human HEK293 N/A
IL2RG-14197H Recombinant Human IL2RG Protein, GST-tagged Human E.coli GST
IL4R-586H Recombinant Human Interleukin 4 Receptor Human HEK293 N/A
IL7R-788H Recombinant Human IL7R, Fc-His tagged Human Human Cell Fc/His

About Common Gamma-Chain Family

The common gamma chain (γc) family refers to a group of cytokines and their corresponding receptors that share a common receptor subunit called the γc or interleukin-2 receptor gamma chain (IL-2Rγ or CD132). This family of cytokines plays essential roles in immune system regulation, cell development, and various physiological processes. The receptors of the γc family, along with their associated cytokines, activate specific signaling pathways that play crucial roles in immune cell function and development. Here are some of the signaling pathways and downstream effects associated with these receptors:

IL-2 signaling pathway

  • IL-2 binds to the IL-2 receptor (IL-2R), which consists of IL-2Rα (CD25), IL-2Rβ (CD122), and the common gamma chain (γc).
  • The binding of IL-2 to the IL-2R triggers the activation of Janus kinases (JAKs) and subsequent phosphorylation of the receptor subunits.
  • This leads to the recruitment and activation of signaling molecules such as signal transducer and activator of transcription 5 (STAT5), phosphoinositide 3-kinase (PI3K), and mitogen-activated protein kinases (MAPKs).
  • Activation of these signaling pathways promotes T cell proliferation, survival, and immune regulation.
  • IL-2 signaling also contributes to the development and maintenance of regulatory T cells (Tregs), which play a critical role in immune tolerance and suppression of excessive immune responses.

IL-4 signaling pathway

  • IL-4 binds to the IL-4 receptor (IL-4R), which consists of IL-4Rα (CD124) and the common gamma chain (γc).
  • The binding of IL-4 to the IL-4R triggers the activation of JAKs and subsequent phosphorylation of the receptor subunits.
  • This leads to the activation of STAT6 and the PI3K-Akt pathway.
  • Activation of these pathways promotes the differentiation of CD4+ T cells into Th2 cells, which are involved in allergic and humoral immune responses.
  • IL-4 signaling also stimulates B cell growth, antibody production, and class switching to IgE.

IL-7 signaling pathway

  • IL-7 binds to the IL-7 receptor (IL-7R), which consists of IL-7Rα (CD127) and the common gamma chain (γc).
  • The binding of IL-7 to the IL-7R activates JAKs and subsequent phosphorylation of the receptor subunits.
  • This leads to the activation of STAT5 and the PI3K-Akt pathway.
  • IL-7 signaling is critical for T cell development, survival, and homeostasis.
  • It promotes the survival and proliferation of immature T cells in the thymus and supports the maintenance of memory T cells in the periphery.

IL-9 signaling pathway

  • IL-9 binds to the IL-9 receptor (IL-9R), which consists of IL-9Rα and the common gamma chain (γc).
  • The binding of IL-9 to the IL-9R activates JAKs and subsequent phosphorylation of the receptor subunits.
  • This leads to the activation of STAT proteins and the PI3K-Akt pathway.
  • IL-9 signaling promotes mast cell proliferation and activation, contributing to allergic responses.
  • It also influences the differentiation of helper T cell subsets, including Th9 cells.

IL-15 signaling pathway

  • IL-15 binds to the IL-15 receptor (IL-15R), which consists of IL-15Rα, IL-2Rβ, and the common gamma chain (γc).
  • The binding of IL-15 to the IL-15R triggers JAK activation and subsequent phosphorylation of the receptor subunits.
  • This leads to the activation of STAT proteins and the PI3K-Akt pathway.
  • IL-15 signaling is crucial for the development, survival, and activation of natural killer (NK) cells and memory CD8+ T cells.
  • It supports the maintenance of these cell populations and enhances their anti-tumor and anti-viral activities.

IL-21 signaling pathway

  • IL-21 binds to the IL-21 receptor (IL-21R), which consists of IL-21R and the common gamma chain (γc).
  • The binding of IL-21 to the IL-21R activates JAKs and subsequent phosphorylation of the receptor subunits.
  • This leads to the activation of STAT proteins, particularly STAT3, and the MAPK pathway.
  • IL-21 signaling regulates B cell activation, antibody production, and immune responses.
  • It influences the formation of germinal centers and the differentiation of B cells into plasma cells and memory B cells.

In summary, the γc family encompasses a group of cytokines that utilize the common gamma chain as a receptor subunit. These cytokines, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, have diverse functions in immune regulation and cell development. Their receptor complexes, which include specific receptor subunits along with the common gamma chain, mediate their signaling and regulate various physiological processes in the immune system.

Schematic of γ chain (γc) family cytokines and their receptors.Fig.1 Schematic of γ chain (γc) family cytokines and their receptors. (Lin JX, et al., 2018)
Shown are how Janus kinase (JAK)1 and JAK3 associate with each receptor, the signal transducers and activators of transcription (STAT) proteins activated by each cytokine, and the major actions of these cytokines on the development and function immune cells. The STAT proteins predominantly activated by each cytokine are in bold.

Therapeutic Strategies Targeting the γc Receptors for the Treatment of Various Diseases

Therapeutic strategies targeting the receptors in the common γc family have shown promise in the treatment of various diseases. Here are some examples of therapeutic approaches that focus on these receptors:

Monoclonal Antibodies

Monoclonal antibodies (mAbs) can be designed to target the receptors of the common γc family, either blocking their function or enhancing their activity. Some examples include:

  • Anti-IL-2R antibodies: Monoclonal antibodies targeting IL-2 receptor subunits, such as IL-2Rα (CD25) and IL-2Rβ (CD122), have been developed. These antibodies can block IL-2 binding and inhibit IL-2 signaling, which can be beneficial in conditions where excessive immune responses need to be suppressed, such as autoimmune diseases.
  • Anti-IL-4R antibodies: Monoclonal antibodies against IL-4 receptor subunits, such as IL-4Rα (CD124), can disrupt IL-4 signaling. By blocking IL-4-induced Th2 cell differentiation and B cell activation, these antibodies have potential applications in allergic diseases and asthma.
  • Anti-IL-7R antibodies: Monoclonal antibodies targeting IL-7 receptor subunits, including IL-7Rα (CD127), have been developed. These antibodies can interfere with IL-7 signaling, which may be beneficial in conditions where T-cell proliferation and survival need to be controlled, such as certain types of leukemia.

Small Molecule Inhibitors

In addition to monoclonal antibodies, small molecule inhibitors can be used to target the signaling pathways associated with the receptors of the common γc family. Some examples include:

  • JAK inhibitors: Janus kinases (JAKs) are key components in the signaling pathways activated by these receptors. Small molecule inhibitors targeting JAKs can block downstream signaling events. JAK inhibitors have shown efficacy in various immune-related diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
  • PI3K inhibitors: The PI3K-Akt pathway is another important signaling pathway downstream of these receptors. Small molecule inhibitors of PI3K can interfere with this pathway, potentially modulating immune cell function. PI3K inhibitors are being investigated in clinical trials for various cancers and autoimmune diseases.

These are just a few examples of therapeutic strategies targeting the receptors in the common γc family. It's worth mentioning that the development and clinical use of these therapies are ongoing, and their efficacy and safety continue to be evaluated through preclinical and clinical studies. The specific choice of therapeutic approach depends on the disease, the specific receptor targeted, and the desired outcome, and it is determined on a case-by-case basis.

Schematic of the γc family of cytokines.Fig.2 Schematic of the γc family of cytokines. (Leonard W J, et al., 2019)

We are committed to helping you achieve your scientific goals and make meaningful contributions to research on the roles of the various components of the common γc family and their role in disease. Contact us today to learn more about our products and resources.

Related References

  1. Leonard W J, Lin J X, O'Shea J J. The γc family of cytokines: basic biology to therapeutic ramifications[J]. Immunity, 2019, 50(4): 832-850.
  2. Lin JX, Leonard WJ. The Common Cytokine Receptor γ Chain Family of Cytokines. Cold Spring Harb Perspect Biol. 2018;10(9):a028449. Published 2018 Sep 4.


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