Active Recombinant Human Calprotectin Protein

• Cat.No.: S100A8-1013H
• Product Overview: Recombinant Human calprotectin heterotetramer (S100A8/S100A9) protein with an Nterminal histidine tag in the S100A8 subunit. Predicted molecular weights: S100A8 12 kDa, S100A9 13 kDa.

Specification

• Description: Calprotectin belongs to the family of S100 proteins and is composed of two subunits S100A8 and S100A9. Increased plasma concentrations are found in response to infections and inflammation. Faecal calprotectin measurement is used for detection of gastrointestinal inflammation or neoplasia and for assessment of inflammatory bowel disease activity and response to treatment
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized from 0.2 μm filtered solution
• Bio-activity: Anti-h Calprotectin 3403: + Anti-h Calprotectin 3404: + Anti-h Calprotectin 3405: + Anti-h Calprotectin 3406: + Anti-h Calprotectin 3407: +
• Molecular Mass: S100A8 12 kDa, S100A9 13 kDa
• Storage: 2–8centigrade
• Concentration: 0.5 mg/ml when reconstituted with 200 µl of deionized water
• Storage Buffer: 20 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 8.0; containing 6 % sucrose as a stabilize
• Reconstitution: Reconstitute lyophilized protein with 200 µl of deionized water

Gene Information

• Gene Name: S100A8 S100 calcium binding protein A8 [ Homo sapiens ]
• Official Symbol: S100A8
• Synonyms: S100A8; S100 calcium binding protein A8; CAGA, CFAG, S100 calcium binding protein A8 (calgranulin A) , S100 calcium binding protein A8 (calgranulin A); protein S100-A8; 60B8AG; CGLA; MRP8; P8; MRP-8; calgranulin A; calgranulin-A; cystic fibrosis antigen; calprotectin L1L subunit; urinary stone protein band A; leukocyte L1 complex light chain; migration inhibitory factor-related protein 8; S100 calcium-binding protein A8 (calgranulin A); MIF; NIF; CAGA; CFAG; L1Ag; CP-10; MA387
• Gene ID: 6279
• mRNA Refseq: NM_002964
• Protein Refseq: NP_002955
• MIM: 123885
• UniProt ID: P05109

Reviews

02/01/2022

Dependable protein quantification, ensures experimental accuracy.

10/29/2020

Consistent western blot results, a lab essential.

03/12/2020

Expert protein engineering support, essential for our projects.

Q&As

How do alterations in S100A8 expression impact cellular stress responses and aging?

Changes in S100A8 expression impact cellular stress responses, with implications for aging and age-related diseases.

How does S100A8 contribute to the pathogenesis of cancer, especially in terms of tumor growth and metastasis?

S100A8 contributes to cancer development, influencing tumor cell proliferation and metastatic potential.

What is the impact of S100A8 on wound healing and tissue repair mechanisms?

S100A8 is involved in wound healing, affecting tissue repair and regeneration.

How does S100A8 interact with calcium ions and what are the implications for inflammatory processes?

S100A8 binds calcium ions, modulating inflammatory processes and cytokine production.

How does S100A8 influence the development and progression of cardiovascular diseases?

S100A8 affects cardiovascular disease development, impacting inflammation and vascular integrity.

What role does S100A8 play in the immune response, particularly in autoimmune diseases?

S100A8 plays a significant role in the immune response, impacting the pathogenesis of autoimmune diseases.

What are the effects of S100A8 on skin homeostasis and the development of skin disorders?

S100A8 influences skin health, playing a role in maintaining skin barrier function and in skin disorders.