CD64

  • Official Full Name

    Cluster of Differentiation 64

  • Overview

    CD64 is the high-affinity IgG Fc receptor belonging to the immunoglobulin supergene family. CD64 is a 72 kDa glycoprotein which binds monomeric IgG (human IgG1>IgG3>>IgG4>>>IgG2 and mouse IgG3>IgG2a>>>IgG1, IgG2b). Three genes: FcγR1A, FcγR1B, and FcγR1C, which have >98 percent identity at the nucleotide level, have been identified and mapped to chromosome 1, band q21.1. The FcγR1A gene, which specifies the high-affinity IgG receptor, encodes three C2-type Ig-like extracellular domains, a 21 amino acid transmembrane region, and a charged cytoplasmic tail of 61 amino acids. CD64 is constitutively expressed on monocytes, macrophages and blood dendritic cells, and at very low levels on neutrophils. It can be induced to higher expression on neutrophils and eosinophils by interferon (IFN) γ and granulocyte colony-stimulating factor (G-CSF). CD64 is expressed in acute myeloid leukaemia with monocytic differentiation (M4 and M5) and in acute promyelocytic leukaemia (M3). CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular toxicity, cytokine release, and superoxide generation.
  • Synonyms

    CD64; CD64 antigen; CD64A; Fc fragment of IgG high affinity Ia receptor; Fc fragment of IgG high affinity Ib receptor; Fc fragment of IgG high affinity Ic receptor; Fc fragment of IgG, high affinity Ia, receptor (CD64); Fc fragment of IgG, high affinity Ia, receptor; Fc fragment of IgG, high affinity Ib, receptor (CD64); Fc fragment of IgG, high affinity Ib, receptor; Fc fragment of IgG, high affinity Ic, receptor (CD64); Fc fragment of IgG, high affinity Ic, receptor; Fc gamma receptor; Fc gamma receptor I A1; Fc gamma receptor I; Fc gamma receptor I B2; Fc gamma RI; Fc of IgG high affinity Ia receptor; Fc-gamma RIC; FCG1; FcgammaRI; FCGR1; FCGR1A; FCGR1B; FCGR1C; FcRI; FCRIC; FLJ18345; High affinity immunoglobulin gamma Fc receptor I; High affinity immunoglobulin gamma Fc receptor IB; IGFR1; IGFRB; IGFRC; IgG Fc receptor I; IgG Fc receptor IC; Immunoglobulin G Fc receptor I; Immunoglobulin G Fc receptor IB; Immunoglobulin G Fc receptor IC; MGC137713;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD64-374H Active Recombinant Human CD64 Protein, His-tagged CHO His Met1-Pro288
  • Other Resource

CD64 involved in several pathways and played different roles in them. We selected most pathways CD64 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CD64 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CD64 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CD64 itself. We selected most functions CD64 had, and list some proteins which have the same functions with CD64. You can find most of the proteins on our site.

Function Related Protein

CD64 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD64 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD64.

Research Area

Related articles

Bieren, JEV; Volpe, B; et al. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I. JOURNAL OF IMMUNOLOGY 194:1154-1163(2015).
Lu, JH; Chu, J; et al. Structure of Fc gamma RI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:833-838(2015).
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