Active Recombinant Human FCER1A, His-tagged, Biotinylated

• Cat.No.: FCER1A-193H
• Product Overview: Human FCER1A Protein, Biotinylated (Biotinylated rh FCER1A) Val 26 - Gln 205 (Accession # NP_001992), was labeled with biotin based on rh FCER1A Protein, which was produced in human 293 cells (HEK293).

Specification

• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
• Bio-activity: Immobilized Immunoglobulin E, Human Plasma at 5 μg/mL (100 μL/well) can bind Human Fc epsilon RI alpha, His Tag with a linear range of 0.4-3 ng/mL.
• Molecular Mass: The protein has a calculated MW of 22.9 kDa. The protein migrates as 37-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: Val 26 - Gln 205
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
  >90% as determined by SEC-MALS.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 centigrade to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide [ Homo sapiens ]
• Official Symbol: FCER1A
• Synonyms: FCER1A; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; FCE1A; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; FcERI
• Gene ID: 2205
• mRNA Refseq: NM_002001
• Protein Refseq: NP_001992
• MIM: 147140
• UniProt ID: P12319

Reviews

11/30/2022

FCER1A can maintain its biological activity and structural integrity under specific experimental conditions.

11/08/2022

FCER1A quality is stable and reliable, with no significant differences between batches.

01/15/2021

FCER1A has high chemical and physical stability and is suitable for long-term storage and use.

Q&As

Is FCER1A expression regulated?

Modulation of FCER1A expression can be achieved through techniques such as gene knockout, gene silencing, or gene transduction. In addition, its expression levels can also be affected by altering environmental factors such as nutrition, inflammation, etc.

How can I detect the expression level of FCER1A?

The expression level of FCER1A can be detected by gene expression profiling or immunohistochemistry.

Is there a role for FCER1A in the immune system?

FCER1A plays a key role in the immune system, recognizing and presenting antigens to T cell receptors, thereby initiating an adaptive immune response.

What diseases is FCER1A associated with?

Studies have shown that FCER1A is associated with the risk of some autoimmune diseases, inflammatory diseases, and certain cancers.

What is the significance of studying FCER1A?

Studying FCER1A can help to gain insight into the mechanisms of immune response and inflammatory response, which is of great significance for the development of new drugs and therapeutic strategies. In addition, it is also of great value for understanding the pathogenesis and prevention of diseases.

How is FCER1A related to other genes or proteins?

FCER1A has complex associations with other genes and proteins, such as its interaction with T cell receptors, inflammatory factors, etc.