| Official Full Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 |
| Background | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. |
| Synonyms | ABCC9; ATP-binding cassette, sub-family C (CFTR/MRP), member 9; SUR2; ABC37; CANTU; CMD1O; ATFB12 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
ABCC9 involved in several pathways and played different roles in them. We selected most pathways ABCC9 participated on our site, such as ABC transporters, ABC-family proteins mediated transport, ATP sensitive Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCC9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCA5; ABCC4; ABCB1A; ABCD3; ABCA1B; ABCA1; ABCB1LB; ABCG3; ABCA6; ABCC11 |
| ABC-family proteins mediated transport | ABCC2; ABCA8; CFTR; EIF2S1; APOA1B; KCNJ11; ABCA7; ABCA4A; ABCB8; ABCF1 |
| ATP sensitive Potassium channels | KCNJ11; ABCC9; KCNJ8 |
| Inwardly rectifying K+ channels | KCNJ2A; KCNJ1B; KCNJ15; KCNJ1; KCNJ14; GNGT2A; KCNJ1A.4; KCNJ1A.5; GNGT2B; KCNJ8 |
| Neuronal System | RERG; SLC6A12; KCNG3; KCNJ11; KCNN2; KCNC2; KCNF1; NCALDA; NSFA; KCNA2 |
| Potassium Channels | KCNMB1; KCNH1B; KCNC4; KCNV2; KCNK16; KCNK3A; KCNJ1A.4; KCNAB2B; KCNC2; KCNN3 |
| Transmembrane transport of small molecules | SLC2A13; ANO9; DMTN; SLC27A4; APOD; SLC26A3.2; HTR3C; SLC7A6; SLC1A3B; SLC35A3A |
ABCC9 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCC9 itself. We selected most functions ABCC9 had, and list some proteins which have the same functions with ABCC9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCC6; KIF3A; HARS; DDX39AA; SYK; ACSM4; TTL; MADD; MCM7; SMC1A |
| ATPase activity, coupled to transmembrane movement of substances | ABCA4; ABCC3; ABCB7; ABCD3A; ABCB4; ABCC5; ABCG5; ABCG3; ATP6V1D; ABCB3L1 |
| ion channel binding | AKAP9; KCNIP1; ABCC9; RNF207; ANK2; ASPH; SRC; CAV3; FKBP1B; KCNB1 |
| potassium channel activity | KCNC3A; TMEM38B; FXYD4; KCNK3; KCNJ11L; KCNIP4; ABCC9; KCNA1; KCNV2B; KCNA2 |
| potassium channel regulator activity | KCNE2; KCNE1; AMIGO1; KCNIP3; PIAS3; KCNMB2; AKAP9; SUMO1; ARPP19A; KCNV1 |
| sulfonylurea receptor activity | ABCC9; ABCC8 |
| transporter activity | SEC14L4; XPO1; MIPB; SLCO1F4; AQP3A; FABP1B.1; ABCA4A; SLC2A11L; SLC22A13; ASNA1 |
ABCC9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCC9 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCC9.
KCNJ11
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