ACSL6
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Official Full Name
acyl-CoA synthetase long-chain family member 6
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Overview
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ACSL6; acyl-CoA synthetase long-chain family member 6; FACL6, fatty acid Coenzyme A ligase, long chain 6; long-chain-fatty-acid--CoA ligase 6; ACS2; KIAA0837; LACS2; LACS5; long fatty acyl-CoA synthetase 2; fatty-acid-Coenzyme A ligase, long-chain 6; FAC;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N
- ACSL6 Related Articles
ACSL6 involved in several pathways and played different roles in them. We selected most pathways ACSL6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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ACSL6 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ACSL6 itself. We selected most functions ACSL6 had, and list some proteins which have the same functions with ACSL6. You can find most of the proteins on our site.
| Function | Related Protein |
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ACSL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSL6.
- Q&As
- Reviews
Q&As (10)
Ask a questionACSL6 expression has been shown to decrease with age, which may contribute to age-related metabolic dysfunction.
Studies have shown that increased ACSL6 expression in adipose tissue is associated with improved insulin sensitivity and decreased risk of developing type 2 diabetes.
ACSL6 is expressed in a variety of tissues, including adipose tissue, liver, muscle, and heart.
ACSL6 is involved in the uptake and utilization of fatty acids in the brain, which plays a critical role in maintaining brain function.
ACSL6 gene expression is regulated by various transcription factors, including PPARs, SREBP-1c, and LXR.
ACSL6 expression is regulated by AMPK, a key cellular energy sensor that activates ACSL6 transcription in response to low energy status.
The C-terminal domain of ACSL6 is responsible for the catalytic activity of the enzyme, which involves the activation of long-chain fatty acids by attaching them to coenzyme A.
ACSL6 is involved in the synthesis and storage of triacylglycerols in lipid droplets, which plays a critical role in maintaining lipid homeostasis.
ACSL6 is involved in the transport of fatty acids into the mitochondria, which is necessary for mitochondrial energy production.
The AMP-binding domain of ACSL6 binds to AMP, which can activate the enzyme and increase its activity.
Customer Reviews (5)
Write a reviewI'm thrilled with the performance of this recombinant protein. It surpassed my expectations in terms of purity and yield.
I'm amazed at the performance of this recombinant protein. It worked flawlessly in my assays, and the results were reproducible.
The high-quality protein allowed me to achieve robust and reliable results. I'm extremely satisfied with my purchase.
Overall, I highly recommend this recombinant protein and the manufacturer for their excellent product and service.
The recombinant protein was delivered promptly, and the packaging ensured its stability. The purity and activity were excellent, and the product performed consistently.
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