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ADO

  • Official Full Name

    2-aminoethanethiol (cysteamine) dioxygenase

  • Overview

    Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase;(ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to;form hypotaurine (Dominy et al., 2007 (PubMed 17581819)).
  • Synonyms

    ADO; 2-aminoethanethiol (cysteamine) dioxygenase; C10orf22, chromosome 10 open reading frame 22; 2-aminoethanethiol dioxygenase; cysteamine dioxygenase; FLJ14547; cysteamine (2-aminoethanethiol) dioxygenase (ADO); C10orf22; DKFZp564C046;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADO-366H Recombinant Human ADO Protein, GST-tagged Wheat Germ GST
Human ADO-9007HCL Recombinant Human ADO 293 Cell Lysate HEK293 N/A
Human ADO-970HF Recombinant Full Length Human ADO Protein, GST-tagged In Vitro Cell Free System GST 228 amino acids
Human ADO-866H Recombinant Human ADO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse ADO-1369M Recombinant Mouse ADO Protein Mammalian Cell His
Mouse Ado-1542M Recombinant Mouse Ado Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ADO-354M Recombinant Mouse ADO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADO-354M-B Recombinant Mouse ADO Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ADO-253R Recombinant Rhesus monkey ADO Protein, His-tagged Mammalian Cell His
Rhesus Macaque ADO-81R Recombinant Rhesus Macaque ADO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ADO-81R-B Recombinant Rhesus Macaque ADO Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADO Related Articles

ADO involved in several pathways and played different roles in them. We selected most pathways ADO participated on our site, such as Taurine and hypotaurine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Taurine and hypotaurine metabolismGGT1;CDO1;CSAD;GAD1;GGT5A;GAD2;GGT5;ADOB;GAD1B
Metabolic pathwaysCYP2C45;GLUD1A;CAD;NT5C3L;GCDHB;GLCE;ACY1;ATP6V0CA;FOLH1

ADO has several biochemical functions, for example, cysteamine dioxygenase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADO itself. We selected most functions ADO had, and list some proteins which have the same functions with ADO. You can find most of the proteins on our site.

Function Related Protein
cysteamine dioxygenase activity
metal ion bindingARHGAP29B;ZC3H13;PDE4C;Car14;PPARAA;ZNF800;RNF148;PCXB;GMPR2

ADO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADO here. Most of them are supplied by our site. Hope this information will be useful for your research of ADO.

FYCO1

Ahmed, S; Sami, A; et al. HER2-directed therapy: current treatment options for HER2-positive breast cancer. BREAST CANCER 22:101-116(2015).
Carneiro, BA; Meeks, JJ; et al. Emerging therapeutic targets in bladder cancer. CANCER TREATMENT REVIEWS 41:170-178(2015).
  • Q&As
  • Reviews

Q&As (17)

Ask a question
Can ADO protein inhibitors cause side effects? 08/28/2022

Yes, like any drug, ADO protein inhibitors can cause side effects. The most common side effects include nausea, vomiting, bone marrow suppression, and immunosuppression.

Can ADO proteins be targeted for gene therapy? 03/30/2022

Yes, gene therapy is an approach that is currently being explored for the treatment of genetic disorders that involve ADO protein deficiencies, such as severe combined immunodeficiency (SCID). This approach involves delivering a functional copy of the ADO gene to cells that are deficient in the enzyme.

How are ADO proteins involved in cancer biology? 03/29/2022

ADO proteins play a role in the regulation of immune responses that can influence tumor growth and development. In tumors, ADO proteins are often overexpressed, leading to increased immune suppression and allowing tumors to grow unchecked. Therefore, targeting ADO proteins is a promising approach for cancer therapy.

Are there any side effects associated with modulating ADO proteins? 09/24/2020

Although modulating ADO proteins has shown therapeutic potential in various diseases, there may be side effects associated with this approach. For example, inhibiting ADO proteins may lead to an increase in inflammation and immune activation, which can have negative effects on the body. Additionally, some drugs that target ADO proteins may have unwanted side effects, such as gastrointestinal disturbances and nausea.

Can ADO proteins play a role in neurodegenerative diseases? 06/09/2020

Research has indicated that ADO proteins may play a role in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. These diseases involve the accumulation of abnormal protein aggregates in the brain, and research has suggested that ADO proteins may play a role in the clearance of these aggregates.

Can ADO protein inhibitors be used for the treatment of viral infections? 04/22/2020

ADO inhibitors have been shown to have antiviral activity against a range of viruses, including HIV, hepatitis C, and Zika virus. They work by blocking the ability of viruses to replicate in host cells.

Are there any drugs that target ADO proteins? 05/29/2019

Yes, there are several drugs that target ADO proteins, including pentostatin, aminophylline, and caffeine. These drugs are used to treat various diseases, including leukemia and asthma, and work by inhibiting the activity of ADO proteins.

What is the future of ADO protein research in the medical field? 05/23/2019

ADO proteins are a promising target for the development of new therapeutics for a range of diseases. Ongoing research is exploring new ADO inhibitors, as well as the potential use of ADO proteins as biomarkers for disease diagnosis and prognosis.

Are there any natural compounds that can modulate ADO proteins? 03/01/2019

Yes, there are natural compounds that have been shown to modulate ADO proteins, such as green tea catechins and resveratrol. These compounds have been shown to have immunomodulatory effects and may be useful in the treatment of various diseases, including cancer and autoimmune diseases.

Can ADO proteins be used to develop new cancer therapies? 01/19/2019

Yes, ADO proteins are a promising target for the development of new cancer therapies. ADO proteins are involved in immune regulation, and cancer cells can exploit this function to evade the immune system. Inhibiting ADO proteins may help to boost the immune response against cancer cells and improve the effectiveness of existing cancer therapies.

Can ADO proteins be used as biomarkers for disease diagnosis? 11/27/2018

ADO proteins have been explored as potential biomarkers for disease diagnosis, including cancer and autoimmune diseases. However, their use as biomarkers is still in the experimental stages, and more research is needed to fully understand their utility in clinical diagnoses.

How are ADO proteins involved in purine metabolism? 07/22/2018

ADO proteins are involved in the catabolism of purine nucleotides, which are essential building blocks for DNA and RNA synthesis. By converting adenosine into inosine, ADO proteins help recycle purines and maintain normal purine metabolism in the body.

How are ADO proteins involved in autoimmune diseases? 06/23/2018

ADO proteins are involved in the regulation of immune responses and play a role in the development of autoimmune diseases. Inhibition of ADO proteins can enhance immune responses and improve the symptoms of autoimmune diseases.

Can ADO protein levels be measured in the blood? 11/03/2017

es, ADO protein levels can be measured in the blood using various laboratory techniques, such as enzyme-linked immunosorbent assay (ELISA). These tests can be useful in diagnosing and monitoring certain diseases, such as leukemia.

Are there any drugs currently available that target ADO proteins? 01/17/2017

Yes, several drugs that target ADO proteins are currently available, including pentostatin and cladribine. These drugs are used to treat hairy cell leukemia, a type of blood cancer.

How do ADO proteins interact with other enzymes in the body? 09/10/2016

ADO proteins interact with other enzymes in the body in various ways. For example, ADO proteins can interact with other enzymes in the purine metabolism pathway, such as purine nucleoside phosphorylase (PNP), to regulate the levels of purine nucleotides in the body. Additionally, ADO proteins can interact with enzymes involved in immune regulation, such as indoleamine 2,3-dioxygenase (IDO), to modulate immune responses.

Can ADO proteins be used as a biomarker for cancer? 02/26/2016

Yes, ADO proteins are currently being investigated as a potential biomarker for various types of cancer, including leukemia, lymphoma, and solid tumors. ADO proteins are produced by cancerous cells and released into the bloodstream, where they can be detected and used to diagnose and monitor the progression of the disease.

Customer Reviews (5)

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Reviews
10/22/2019

    the technical assistance team has been incredibly helpful in answering my questions and providing guidance on how to optimize my research.

    09/21/2018

      This protein is of exceptional quality and perfectly suited for my experimental requirements.

      09/01/2018

        I feel confident in my decision to use this protein and grateful for the excellent support from the manufacturer.

        06/13/2018

          The analytical testing report confirms that it meets all the required specifications for my experiment.

          09/29/2017

            The technical support offered by the manufacturer has been outstanding, ensuring that any issues or concerns I had were promptly resolved.

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