akap13
Share
  • Official Full Name
  • A kinase (PRKA) anchor protein 13
  • Background
  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.
  • Synonyms
  • AKAP13; A kinase (PRKA) anchor protein 13; LBC, lymphoid blast crisis oncogene; A-kinase anchor protein 13; AKAP Lbc; ARHGEF13; BRX; c lbc; HA 3; Ht31; PROTO LB; p47; AKAP-13; LBC oncogene; A-kinase anchoring protein; lymphoid blast crisis oncogene; huma
Cat.#:AKAP13-399HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKAP13 Protein, GST-tagged
+Inquiry
Cat.#:AKAP13-45HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AKAP13 cell lysate
+Inquiry

Involved Pathway

AKAP13 involved in several pathways and played different roles in them. We selected most pathways AKAP13 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G Protein Signaling Pathways, G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADE
ITGB3BP; ARHGEF17; NET1; KALRNB; ARHGEF1A; BCL2L11; FGD4A; ARHGEF18; ARHGAP4A; FGD4
G Protein Signaling Pathways
KCNJ3; AKAP13; AKAP8; GNGT2A; AKAP5; GNA13; AKAP4; AKAP1; AKAP10; Akap2
G alpha (12/13) signalling events
ARHGAP4A; ARHGEF16; ADRA1D; GNA13B; PLEKHG2; ECT2; ARHGEF18A; MCF2L; RHOAE; RHOC
GPCR downstream signaling
RHOL; PLEKHG2; FGD4A; OXGR1; OR56A1; PROKR1; OR10A5; RGS4; OXGR1A.2; OR52B4
NRAGE signals death through JNK
FGD4; MCF2L; ARHGAP4; ECT2; TIAM2; PLEKHG2; ABR; OBSCN; AATF; ARHGEF1A
Regulation of RhoA activity
ECT2; ABR; FARP1; ARHGEF15; PLEKHG6; ARHGAP9; DEF6; MCF2L; ARHGEF18; ARHGEF28
Rho GTPase cycle
DEPDC1B; ARHGEF18A; RHOJ; FAM13A; ARHGAP29; ARHGAP11A; ARHGAP28; ARHGAP32; GDI1; TAGAP
Signal Transduction
TLE3B; LINGO1B; GUCA1E; ARAP1; ARHGEF3; OMG; RDH7; UCHL5; PTH2; USP2

Protein Function

AKAP13 has several biochemical functions, for example, Rho GTPase binding, Rho guanyl-nucleotide exchange factor activity, cAMP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP13 itself. We selected most functions AKAP13 had, and list some proteins which have the same functions with AKAP13. You can find most of the proteins on our site.
Function
Related Protein
Function Rho GTPase binding
Related Protein CDC42BPB; DIAP3; DIAPH3; ROCK2; ARHGEF16; DAPK3; FLNA; CSDA; DOCK9; AKAP13
Function Rho guanyl-nucleotide exchange factor activity
Related Protein NET1; ARHGEF12; MCF2L; VAV3; DOCK10; VAV3B; ITSN2A; PREX1; SOS1; ARHGEF3L
Function cAMP-dependent protein kinase activity
Related Protein PRKX; AKAP13; PRKAA1; PRKAG1; PRKACG; PRKACB; PRKACA
Function metal ion binding
Related Protein ZNF583; RAB11FIP4; ERI3; IKZF5; TIMM10B; CAR5A; SP5A; ANG3; CDH24; PDE4C
Function protein binding
Related Protein HSPBAP1; CRY2; NCAPH; NKX2; UBL4B; ARL6IP5; MESDC1; C20orf20; SPHK1; FGFBP1
Function protein complex scaffold
Related Protein PKP2; DISC1; TELO2; WWC3; SMARCD1; AKAP13; ISCU; SLC9A1; WWC1; HOMER1
Function protein kinase A binding
Related Protein RPS3; AKAP14; LRRK2; DACT3; AKAP4; AKAP6; DACT2; Akap2; AKAP5; MYRIP
Function signal transducer activity
Related Protein MAPKAPK5; TAS2R201.1; STAT6; GNB1; MRGPRB8; TAAR4; EDNRBA; PLCB4; TAS2R124; GNB4

Interacting Protein

AKAP13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP13 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP13.
YWHAB; ESR1; YWHAG; TGM2; THRA; Ppara; YWHAZ; BAK1; RANBP2; uvrB; lysU; q7arb9_yerpe