akr1c1
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  • Official Full Name
  • aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
  • Background
  • This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
  • Synonyms
  • AKR1C1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); DDH1; aldo-keto reductase family 1 member C1; DD1; DDH; HAKRC; MBAB; 2-dihydrobenzene-1; 2-diol dehydrogenase; 20 alpha (3 alpha) hydroxysteroid dehydrogenase; 20 ALPHA HSD; 20 alpha hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20ALPHAHSD; 2ALPHAHSD; AK1C1; AK1C1_HUMAN; Aldo keto reductase family 1 member C1; C9; Chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1/DD2; Dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase isoform DD1; H37; HBAB; Hepatic dihydrodiol dehydrogenase; High affinity hepatic bile acid-binding protein; High-affinity hepatic bile acid-binding protein; Indanol dehydrogenase; MGC8954; Trans-1; Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase; Type II 3 alpha hydroxysteroid dehydrogenase; OTTHUMP00000018992; OTTHUMP00000018993; aldo-keto reductase C; 20 alp; H-37; 2-ALPHA-HSD
Cat.#:AKR1C1-27156THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C1, His-tagged
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Cat.#:AKR1C1-27157THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C1, His-tagged
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Cat.#:AKR1C1-2028HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C1, His-tagged
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Cat.#:AKR1C1-411HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKR1C1 Protein, GST-tagged
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Cat.#:AKR1C1-289CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus AKR1C1 Protein, His-tagged
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Cat.#:AKR1C1-293RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKR1C1 Protein, His-tagged
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Cat.#:AKR1C1-48HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AKR1C1 cell lysate
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Involved Pathway

AKR1C1 involved in several pathways and played different roles in them. We selected most pathways AKR1C1 participated on our site, such as Adaptive Immune System, Aldosterone synthesis and secretion, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
FRS2; ASB17; UBE2E3; CHUK; FGF18B; FGF8B; NRG2A; UBE2F; RAP1GAP2B; CTSD
Aldosterone synthesis and secretion
CALM4; HSD3B2; ATF1; HSD3B1; CREB3L1; PRKACA; PRKCG; AGTR1B; NR4A1; PRKD1
Alzheimers disease
PLCB3; CYCS; NDUFA1; ATP5C1; CASP9; PPP3CB; COX4I1; BACE1; NAE1; NDUFB9
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
IGHM; AKR1C1; IGKC; AHCYL1; BLK; PIK3AP1; STIM1B; IGLC2; IGKV1-5; ITPR2
Calcium Regulation in the Cardiac Cell
ADRA1B; GJA10; ADRB2; KCNJ3; KCNB1; RGS16; CX34.4; CHRM1; RGS5B; GNB5B
Calcium signaling pathway
MYLK; ADRB1; STIM1A; PPP3CB; PTK2BB; CAMK2D2; GRM1; P2RX3B; P2RX3A; ADCY1B
Cholinergic synapse
PIK3R1; GNG2; GNAI3; BCL2; GNG10; CHRM2; KCNJ12; CHRNB4; NRAS; PIK3CD
Circadian entrainment
GNGT1; CALML5; GRIN2D; PLCB4; CALM3; CAMK2A; PRKG2; PER2; PLCB1; RPS6KA5

Protein Function

AKR1C1 has several biochemical functions, for example, calcium channel activity, calcium ion binding, inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C1 itself. We selected most functions AKR1C1 had, and list some proteins which have the same functions with AKR1C1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium channel activity
Related Protein PANX1; PDE2A; CUL5; CACNA1C; TRPC4B; MCU; CACNG1A; CACNG2A; TRPV4; TRPC2
Function calcium ion binding
Related Protein SLC24A2; PCDHGA1; NCS1B; MEX3B; DUOX2; PCDH17; MMP30; PTBP3; MYL9B; GM5077
Function inositol 1,3,4,5 tetrakisphosphate binding
Related Protein ADAP1; ITPR3; SYT2; AKR1C1; ADAP2
Function inositol 1,4,5 trisphosphate binding
Related Protein AKR1C1; TRPC7; RPH3A; TRPC5A; ITPR3; TRPC1; TRPC6A; TRPC7A; TRPC5; PLCL1
Function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Related Protein ITPR3; AKR1C1; ITPR1; ITPR2
Function inositol hexakisphosphate binding
Related Protein ITPR3; AKR1C1
Function intracellular ligand-gated calcium channel activity
Related Protein AKR1C1; ITPR1; RYR2; TRPA1; ITPR3
Function ion channel activity
Related Protein GRIK5; KCNS3B; FXYD6; GJD3; CACNA1DA; TRPM5; CLCN3; SCN1LAB; TPCN1; ITPR1
Function phosphatidylinositol binding
Related Protein ZCCHC2; SH3PXD2A; SNX19A; SNX5; SNX1; SNX2; SNX6; MYO1E; ARHGAP33; SNX10B
Function protein binding
Related Protein MLLT4; VDAC1; ERCC5; TSN; FIGNL1; PSMB4; RBFA; CXCL14; TCEAL5; RTN2

Interacting Protein

AKR1C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C1.
PTPN3; MAPK3; COMMD8; FN1