AKT3A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | AKT3A-7822Z | Recombinant Zebrafish AKT3A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
AKT3A involved in several pathways and played different roles in them. We selected most pathways AKT3A participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
MAPK signaling pathway | PAK2B;TAB2;NTRK1;TGFBR2;NF1;NRAS;CDC25B;MRAS;RELB |
ErbB signaling pathway | PIK3CG;MTOR;MAP2K4;PIK3CD;GSK3B;PIK3R3B;KRAS;CAMK2G;RAF1A |
FoxO signaling pathway | CCND2A;IL6;TGFBR1B;PIK3R3;INSRA;BCL6;MAPK10;PIK3R1;GRB2A |
mTOR signaling pathway | PRKCG;RPS6KB1;MLST8;RRAGD;PRKCA;RPS6KA1;ULK3;PRR5;RPS6KA3A |
Apoptosis | BIRC5A;CASP4;AIFM1;NFKB1;DFFA;CASP3A;NGF;ENDOG;BIDA |
Adrenergic signaling in cardiomyocytes | BCL2A;ATP1B2;ADRB2;CACNG8;PLCB1;PIK3R1;MYL2;SCN1BA;CACNG2 |
VEGF signaling pathway | PLA2G4D;NRAS;MAPK12A;PLA2G4AA;PRKCG;PTGS2;AKT1;MAPKAPK3;PIK3R2 |
Focal adhesion | RHOB;LAMB1;RAP1B;MAPK9;ITGA6;LAMB3;THBS4A;THBS2;TNK2 |
Tight junction | F11R;CLDNH;PPP2CB;MYL2;YBX3;MYH13;AKT2;HCLS1;PRKCE |
Toll-like receptor signaling pathway | RAC1A;NFKBIA;MAPK12;MAP3K7;TLR5;TLR4;LBP;TLR2-1;IFNA1 |
Jak-STAT signaling pathway | SOCS1;RAF1B;AKT2L;IL20RB;IL7;STAT1B;IFNPHI3;CNTFR;IL12RB2 |
Insulin signaling pathway | MAP2K2A;PRKAR2A;TSC2;PIK3R3A;RAF1B;MKNK2;CALM2;PKLR;PDE3B |
Progesterone-mediated oocyte maturation | RPS6KA2;ARAF;PDE3B;RPS6KAL;CPEB4;Adcy4;INS1;PIK3CD;PGR |
Adipocytokine signaling pathway | CAMKK1A;RXRAA;POMC;JAK2B;NFKBIE;ACSL3B;MAPK10;MAPK8B;TNFRSF1B |
Insulin resistance | PRKCDA;PCK1;NFKBIAB;OGT.1;PPP1CA;RPS6KAL;RELA;PRKAB2;PTPN1 |
AKT3A has several biochemical functions, for example, ATP binding, kinase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT3A itself. We selected most functions AKT3A had, and list some proteins which have the same functions with AKT3A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | PPIP5K2;KIF23;NME2B.2;CLK2A;RARS2;DDX51;UBE2J2;FBXO18;GC3 |
kinase activity | RPS6KAL;CKBB;NLK2;PI4KAA;SPS2;CAMKK1B;PAK2B;RPS6KB1B;CCNE1 |
nucleotide binding | DNM2B;NXF3;SMYHC3;PRKG1A;HNRPLL;TNK2B;PTK2AB;EIF3G;MAPKAPK2A |
protein kinase activity | STK30;INSRA;MINK1;NPRL2;PRKACAB;MYO3A;RAF1A;DYRK1A;TRIM28 |
protein serine/threonine kinase activity | TBK1;AURKA;CDKL5;NEK10;DAPK1;CHEK2;TGFBR1A;FASTK;PRKCI |
transferase activity | COQ2;HHAT;TGM2B;PHKG1A;PRKACAB;METTL7B;GOT2A;B3GNT2A;ROCK2B |
AKT3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT3A here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT3A.
- Q&As
- Reviews
Q&As (8)
Ask a questionSince AKT3A is a specific isoform of AKT3, any inhibitors or modulators targeting AKT3 are likely to affect AKT3A as well. Several AKT inhibitors that broadly target AKT isoforms, including AKT3, have been developed and tested in preclinical and clinical studies. These inhibitors can potentially modulate AKT3A-mediated signaling pathways.
The specific substrates phosphorylated by AKT3A protein have not been well-elucidated. AKT3 isoforms, in general, can phosphorylate a wide range of substrates involved in cellular processes such as apoptosis, metabolism, cell cycle regulation, and cell survival. Some well-known substrates of AKT isoforms include FOXO transcription factors, mTOR, GSK-3, and Bad. It is plausible that AKT3A may phosphorylate similar substrates, but further research is needed to identify and characterize the specific substrates targeted by AKT3A.
The expression pattern of AKT3A protein in different tissues has not been extensively studied, and specific data on its expression levels and distribution are limited. However, AKT3 isoforms, including AKT3A, are generally expressed in various tissues and cell types. It is likely that the expression of AKT3A may be influenced by specific cellular contexts and conditions. Further research is needed to determine the tissue-specific expression patterns of AKT3A protein.
The involvement of AKT3A protein in disease associations has not been extensively studied or reported in the available literature. However, dysregulation of AKT signaling has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic disorders. Changes in AKT3 activity or expression levels have been observed in certain types of cancer, such as breast and ovarian cancer. Additionally, mutations in the AKT3 gene have been associated with a rare developmental disorder called microcephaly with pontine cerebellar hypoplasia. It is possible that AKT3A may have disease associations similar to other AKT isoforms, but further research is needed to determine its specific role in disease pathways.
The specific associations between AKT3A protein and diseases have not been extensively studied or reported in the literature. However, given that aberrant AKT signaling is implicated in various diseases, including cancer, neurological disorders, and metabolic disorders, it is possible that alterations or dysregulation of AKT3A isoform could contribute to the development or progression of certain diseases. Additional research is required to determine if AKT3A has any disease-specific roles or associations.
The specific interaction partners of AKT3A protein have not been extensively studied or reported in the available literature. However, AKT isoforms, including AKT3, are known to interact with a wide range of proteins involved in various cellular processes. Some well-established interacting partners of AKT isoforms include growth factor receptors, phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and glycogen synthase kinase-3 (GSK-3). It is possible that AKT3A may have similar interaction partners, but further research is needed to determine the specific protein-protein interactions involving AKT3A.
AKT3A is a specific variant of the AKT3 protein that may have distinct functional properties compared to other isoforms. The exact differences between AKT3A and other AKT3 isoforms are not well-defined in the scientific literature. It is possible that AKT3A may have unique expression patterns, regulatory mechanisms, or interactions with specific proteins, which could influence its role in cellular signaling pathways.
The regulation of AKT3A protein is not well-characterized, and specific studies on AKT3A regulation are limited. However, AKT proteins, in general, are regulated through phosphorylation and dephosphorylation events by various upstream kinases and phosphatases. Stimuli such as growth factors, hormones, and cellular stress can activate these signaling pathways to affect AKT activation and subsequent downstream signaling. Additional research is required to better understand the regulation of AKT3A isoform specifically.
Customer Reviews (3)
Write a reviewWith the AKT3A protein in my arsenal, I am inspired to undertake my scientific investigations with great enthusiasm and confidence.
I know that any potential challenges or hurdles I may encounter will be swiftly addressed, thanks to the manufacturer's reliable and efficient technical support team.
Its high quality and the manufacturer's remarkable technical support combine to ensure that my research endeavors are executed with optimal efficiency and accuracy.
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