|Official Full Name||ALX homeobox 4|
|Background||This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones,;limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant;disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of;frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development,;mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing;this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies,;mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use;dual translation initiation sites located 16 codons apart.|
|Synonyms||ALX4; ALX homeobox 4; aristaless like homeobox 4 , parietal foramina 2 , PFM2; homeobox protein aristaless-like 4; FPP; KIAA1788; PFM; Aristaless like homeobox 4; aristaless-like homeobox 4; FND2; homeobox protein aristaless like 4; homeodomain transcription factor ALX4; PFM1; PFM2; OTTHUMP00000233417|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ALX4 involved in several pathways and played different roles in them. We selected most pathways ALX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
ALX4 has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALX4 itself. We selected most functions ALX4 had, and list some proteins which have the same functions with ALX4. You can find most of the proteins on our site.
|DNA binding||PBX1A; ZBTB42; ZNF124; ZFP580; HIST3H2A; RAD50; NPAS4; HOXD4A; SERPINA3; PIN4|
|HMG box domain binding||MEOX1; SP1; HHEX; HOXC4; PAX3; OLIG2; UTF1; EGR2; GATA3; POU3F3|
|RNA polymerase II regulatory region sequence-specific DNA binding||RUNX3; CREB3; ZNF79; JARID2; KAT2B; ZNF812; PRDM12B; ZBTB16A; NME2; SP5|
|protein heterodimerization activity||FLOT1; VAPA; HIST4H4; HIST1H3G; SIM2; MPP7; PVALB; TFDP3; GRIN1; SPTA1|
|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding||OVOL2; IRF2; NKX2; NKX2-5; TRPS1; MAFBB; BARX2; CTCF; MYOD1; HSF2|
ALX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALX4.