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Official Full Name ALX homeobox 4
Background This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones,;limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant;disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of;frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development,;mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing;this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies,;mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use;dual translation initiation sites located 16 codons apart.
Synonyms ALX4; ALX homeobox 4; aristaless like homeobox 4 , parietal foramina 2 , PFM2; homeobox protein aristaless-like 4; FPP; KIAA1788; PFM; Aristaless like homeobox 4; aristaless-like homeobox 4; FND2; homeobox protein aristaless like 4; homeodomain transcription factor ALX4; PFM1; PFM2; OTTHUMP00000233417
    • Species :
    • Chicken
    • Human
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALX4-511H Recombinant Human ALX4 protein, GST-tagged Wheat Germ GST
    Human ALX4-754H Recombinant Human ALX4 Mammalian Cell His
    Human ALX4-8889HCL Recombinant Human ALX4 293 Cell Lysate HEK293 N/A
    Chicken ALX4-5737C Recombinant Chicken ALX4 Mammalian Cell His

    ALX4 involved in several pathways and played different roles in them. We selected most pathways ALX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    ALX4 has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALX4 itself. We selected most functions ALX4 had, and list some proteins which have the same functions with ALX4. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding PBX1A; ZBTB42; ZNF124; ZFP580; HIST3H2A; RAD50; NPAS4; HOXD4A; SERPINA3; PIN4
    HMG box domain binding MEOX1; SP1; HHEX; HOXC4; PAX3; OLIG2; UTF1; EGR2; GATA3; POU3F3
    RNA polymerase II regulatory region sequence-specific DNA binding RUNX3; CREB3; ZNF79; JARID2; KAT2B; ZNF812; PRDM12B; ZBTB16A; NME2; SP5
    protein heterodimerization activity FLOT1; VAPA; HIST4H4; HIST1H3G; SIM2; MPP7; PVALB; TFDP3; GRIN1; SPTA1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding OVOL2; IRF2; NKX2; NKX2-5; TRPS1; MAFBB; BARX2; CTCF; MYOD1; HSF2

    ALX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALX4.

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