ARHGAP12A

While there is limited information on disease-associated mutations in ARHGAP12A, studies have identified genetic variations in the gene that could potentially contribute to disease susceptibility or altered protein function. However, more in-depth research is needed to fully understand the impact of these mutations.

The known interacting proteins of ARHGAP12A include Rho GTPases, such as RhoA and Cdc42, which are substrates of ARHGAP12A for GTPase-activating protein (GAP) activity. Other potential interacting proteins include components of the cytoskeleton, such as actin and myosin, as well as signaling molecules involved in the regulation of Rho GTPase signaling pathways.

ARHGAP12A contains an array of specific domains, including a BAR (Bin/Amphiphysin/Rvs) domain and an RhoGAP domain. The BAR domain assists in membrane curvature sensing and generation, while the RhoGAP domain enables the regulation of Rho family GTPase activity.

ARHGAP12A plays a role in neuronal development by regulating cytoskeletal remodeling. It guides the extension and branching of neuronal processes, aiding in the formation and connectivity of the nervous system.

It is possible that microRNAs can regulate the expression or function of ARHGAP12A, but specific microRNAs that target ARHGAP12A have not been extensively studied. MicroRNA-mediated regulation of ARHGAP12A may play a role in the fine-tuning of Rho GTPase signaling and cellular processes influenced by ARHGAP12A. Further research is needed to identify microRNAs that may interact with ARHGAP12A.

Although there is limited research on the specific involvement of ARHGAP12A in neurological disorders, alterations in Rho GTPase activity and cytoskeletal dynamics, which are regulated by ARHGAP12A, have been implicated in various neurological conditions such as neurodevelopmental disorders and neurodegenerative diseases.

There is evidence to suggest that ARHGAP12A may play a role in cancer progression. Studies have shown that ARHGAP12A expression and activity are altered in various types of cancer, including colorectal cancer, gastric cancer, and glioblastoma. However, more research is needed to fully understand the mechanisms and clinical significance of ARHGAP12A in cancer progression.

While there is limited research on specific disease associations with ARHGAP12A, altered expression of the protein has been observed in certain cancers. It has been implicated in breast, colorectal, and lung cancers, suggesting a potential role in tumor growth and metastasis.

Given its involvement in various cellular processes and potential implications in diseases, including cancer and cardiovascular disorders, ARHGAP12A could be a potential target for therapeutic interventions. However, more research is needed to fully understand its mechanisms and identify specific therapeutic strategies.

The specific protein-protein interactions of ARHGAP12A are still being elucidated. However, as a RhoGAP protein, it is expected to interact with Rho GTPases and potentially other cytoskeletal and signaling proteins to modulate cellular processes.

ARHGAP12A is involved in regulating endothelial cell migration and angiogenesis, which is the process of new blood vessel formation. It helps coordinate the proper formation and branching of blood vessels during development and tissue repair.

Animal models such as mice are commonly used to study the function of ARHGAP12A. Knockout or transgenic mouse models, where the ARHGAP12A gene is either disrupted or overexpressed, help in understanding its role in development, disease, and tissue-specific functions.

ARHGAP12A exhibits tissue-specific expression patterns, with higher levels observed in certain tissues such as the brain and heart. Its expression can also vary depending on the developmental stage and physiological conditions. Studies have reported differential expression of ARHGAP12A in various tissues, suggesting potential tissue-specific functions.

Yes, ARHGAP12A is known to play a role in cell adhesion and migration. It influences the activity of Rho GTPases, which are crucial regulators of these cellular processes. By modulating Rho GTPase activity, ARHGAP12A can affect cytoskeletal dynamics and alter cell adhesion and migration.

Yes, ARHGAP12A is expressed in immune cells and is involved in regulating their functions. It has been implicated in immune cell migration, cytokine production, and phagocytosis. Understanding the specific contributions of ARHGAP12A to immune cell biology is an active area of research.

The post-translational modifications of ARHGAP12A are not extensively characterized. However, phosphorylation and sumoylation have been reported as potential modifications that could regulate the activity and function of ARHGAP12A.