ARHGAP17
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Official Full Name
Rho GTPase activating protein 17
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Synonyms
ARHGAP17;Rho GTPase activating protein 17;18239;ENSG00000140750;PP367;RICH1;WBP15;MST066;MST110;NADRIN;PP4534;RICH1B;MSTP038;MSTP066;MSTP110;16p12.1;FLJ37567, FLJ43368, MGC87805, DKFZp564A1363;rho GTPase-activating protein 17;rho GTPase-activating protein 17;RICH-1;rho-type GTPase-activating protein 17;RhoGAP interacting with CIP4 homologs 1;rhoGAP interacting with CIP4 homologs protein 1;neuron-associated developmentally regulated protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ARHGAP17-763H | Recombinant Human ARHGAP17 protein, GST-tagged | Wheat Germ | GST |
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| Human | ARHGAP17-8743HCL | Recombinant Human ARHGAP17 293 Cell Lysate | HEK293 | N/A |
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| Human | ARHGAP17-1218HF | Recombinant Full Length Human ARHGAP17 Protein, GST-tagged | In Vitro Cell Free System | GST | 881 amino acids |
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| Human | ARHGAP17-6620H | Recombinant Human ARHGAP17 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | Arhgap17-245M | Recombinant Mouse Arhgap17 Protein, His-tagged | E.coli | N-His | Gln14-Phe442 |
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| Mouse | Arhgap17-1680M | Recombinant Mouse Arhgap17 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | ARHGAP17-763R | Recombinant Rat ARHGAP17 Protein | Mammalian Cell | His |
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| Rat | ARHGAP17-419R-B | Recombinant Rat ARHGAP17 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ARHGAP17-419R | Recombinant Rat ARHGAP17 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
ARHGAP17 involved in several pathways and played different roles in them. We selected most pathways ARHGAP17 participated on our site, such as Regulation of CDC42 activity, Regulation of RAC1 activity, Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of CDC42 activity | ITSN2;DOCK9;ARHGAP17;MCF2L;SPATA13;ARHGEF25;DOCK6;ARHGAP1;RALBP1 |
| Regulation of RAC1 activity | CHN2;ABR;ARHGAP1;PREX2;EPS8;SPATA13;RALBP1;ARHGAP17;CHN1 |
| Rho GTPase cycle | RALBP1;GMIP;OBSCN;RHOU;ARHGAP28;ARHGAP18;MYO9B;DEPDC7;NET1 |
| Signal Transduction | RGS1;FSTL1A;DACT1;OTULIN;NOXA1;CNGA1;RLBP1A;APLNR;SKILB |
| Signaling by Rho GTPases | FGD2;ARHGAP15;ARHGAP6;ARHGAP24;ARHGEF18A;RHOT1;ARHGAP18;RHOT2;RTKN |
ARHGAP17 has several biochemical functions, for example, GTPase activator activity, SH3 domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP17 itself. We selected most functions ARHGAP17 had, and list some proteins which have the same functions with ARHGAP17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ACAP1;ALDH1A2;ASAP2A;RAP1GDS1;TBC1D2;RAP1GAP2A;GAPVD1;TBC1D16;SH3BGRL3 |
| SH3 domain binding | NCF1;MAPK15;ZFP106;RAD9;ARHGAP6;CD2AP;DENND1A;ADAM9;SGIP1 |
| protein binding | ATMIN;THOC2;GNB1B;ZDHHC13;MAPK14;CTLA4;TRAPPC2;STAC;NAA38 |
ARHGAP17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP17 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP17.
TRIP10; AMOT; Amot; AMOT; SLC9A3R1; AMOT; DNMBP; yitU; PACSIN1; Trp53bp1; pi3p; ARRB2
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is limited information on ARHGAP17 polymorphisms associated with phenotypic variations in humans. The genetic variations or single nucleotide polymorphisms (SNPs) within ARHGAP17 and their association with specific traits, diseases, or phenotypic variations have not been well-investigated. Further studies are necessary to understand the impact of ARHGAP17 polymorphisms on human phenotypes.
While there is limited research on the specific role of ARHGAP17 in cancer, dysregulation of Rho GTPases and other GAP proteins has been implicated in cancer progression. Since ARHGAP17 negatively regulates RhoA, alterations in its expression or function may impact tumor cell behavior, invasion, and metastasis. Further studies are needed to explore the potential involvement of ARHGAP17 in cancer.
The specific functional or regulatory interactions between ARHGAP17 and other GAP proteins have not been extensively studied. However, as ARHGAP17 belongs to the GAP family, there could be potential interactions with other GAP proteins that regulate Rho GTPases. Further research is needed to explore these possible interactions.
Currently, there are no known drugs or compounds specifically targeted towards ARHGAP17. However, since ARHGAP17 regulates RhoA signaling, drugs targeted at RhoA or other downstream effectors may indirectly affect ARHGAP17 function. Therapeutic strategies that modulate RhoA activity could potentially impact ARHGAP17-mediated processes.
Due to the limited understanding of ARHGAP17's function and its direct involvement in specific diseases, it is not currently considered a well-established therapeutic target. However, further research may uncover specific contexts where modulating ARHGAP17 activity could be beneficial, particularly in diseases related to abnormal Rho GTPase signaling.
Limited research has been conducted on the association of ARHGAP17 with human diseases. However, altered expression or mutations in Rho GTPases or other GAP proteins have been implicated in several diseases, including cancer, neurological disorders, and cardiovascular diseases. More studies are needed to determine if ARHGAP17 alterations contribute to disease development.
Customer Reviews (8)
Write a reviewThey may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ARHGAP17 protein in their studies.
These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.
Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.
the manufacturer's support is crucial for researchers using ARHGAP17 protein in trials.
Its unwavering stability and functionality have significantly contributed to the success and validity of my experimental outcomes.
Trusting in its consistent results, I am able to embark on my research with assurance and optimism.
the ARHGAP17 protein stands out for its exceptional quality, coupled with the outstanding technical support delivered by the manufacturer.
I enthusiastically recommend the ARHGAP17 protein to fellow researchers who seek an unparalleled product accompanied by dedicated customer assistance.
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