ARHGAP36
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Official Full Name
Rho GTPase activating protein 36
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Synonyms
ARHGAP36; Rho GTPase activating protein 36; rho GTPase-activating protein 36; FLJ30058; hypothetical protein FLJ30058; Hypothetical protein LOC158763; Putative Rho GTPase activating protein FLJ46335; RP13 102H20.1; OTTHUMP00000024023; OTTHUMP00000024024; OTTHUMP00000024026; OTTHUMP00000215137; RP13-102H20.1;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Mouse | ARHGAP36-1873M | Recombinant Mouse ARHGAP36 Protein | Mammalian Cell | His | ||
Mouse | ARHGAP36-682M | Recombinant Mouse ARHGAP36 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ARHGAP36-682M-B | Recombinant Mouse ARHGAP36 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ARHGAP36 Related Articles
ARHGAP36 involved in several pathways and played different roles in them. We selected most pathways ARHGAP36 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Rho GTPase cycle | MCF2L;STARD13;ARHGAP32;ARHGAP15;ARHGAP9;ARHGAP44;FAM13B;ARHGAP17;ARHGAP26 |
Signal Transduction | OR4D2;CBY1;ARHGAP22;ARHGEF1B;ARHGAP32;TJP2B;EMR3;NRP2;OPN4B |
Signaling by Rho GTPases | LIN7B;ARHGAP17A;WIPF3;RHOT1A;ARHGAP17B;ABI1A;DLC1;KIF14;ARHGAP44 |
ARHGAP36 has several biochemical functions, for example, GTPase activator activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP36 itself. We selected most functions ARHGAP36 had, and list some proteins which have the same functions with ARHGAP36. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | TBC1D9;ARHGDIA;RGS11;OPHN1;TBC1D19;BCR;EVI5L;AXIN1;GAPVD1 |
molecular_function | MARF1;DCST1;JPH4;CRYGM2D4;MRGPRA2A;PIGO;REEP3B;LYPD6;C20orf7 |
ARHGAP36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP36 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP36.
- Q&As
- Reviews
Q&As (14)
Ask a questionAs ARHGAP36 is involved in various cellular processes, it holds therapeutic potential. By modulating its activity or targeting its interactions, it may be possible to design interventions for neurodevelopmental disorders, cancer, or other conditions influenced by ARHGAP36.
At present, there are no known drugs or compounds that specifically target ARHGAP36. However, ongoing research may identify potential molecules that can modulate its activity in the future.
ARHGAP36 is expressed in various tissues, including the brain, heart, liver, and skeletal muscle. Its expression is developmentally regulated.
ARHGAP36 acts as a Rho GTPase-activating protein (GAP), promoting the inactivation of Rho GTPases and influencing actin cytoskeleton rearrangements involved in cell migration, adhesion, and shape changes.
Post-translational modifications of ARHGAP36, such as phosphorylation or ubiquitination, have not been extensively studied. More research is needed to elucidate the potential impact of such modifications on ARHGAP36 function.
Yes, several genetic mutations and variants have been identified in ARHGAP36. Some studies have linked specific mutations to neurodevelopmental disorders, such as intellectual disability and autism spectrum disorders.
The transcriptional regulation of ARHGAP36 is not well characterized. Further studies are required to understand the specific transcription factors and regulatory elements that control its expression.
ARHGAP36's role in neuronal morphogenesis suggests that dysfunction or alteration of its activity may contribute to neurodevelopmental disorders by affecting neuronal connectivity and synaptic function.
Yes, animal models like mice and zebrafish are used to study ARHGAP36. Knockout or mutant models can provide insights into the consequences of ARHGAP36 disruption in development and disease.
ARHGAP36 interacts with Rho GTPases (such as RhoA and Rac1), NMDA receptor subunits, and PSD-95, suggesting its involvement in complex signaling networks within cells.
ARHGAP36 interacts with NMDA receptor subunits and PSD-95, suggesting its involvement in synaptic signaling and plasticity. It likely influences the dynamics of dendritic spines, which play a role in synaptic remodeling and learning processes.
ARHGAP36 regulates dendritic arborization and spine development, which are important for proper neuronal connectivity and synaptic function.
While the exact role of ARHGAP36 in cancer is not fully understood, studies have suggested its involvement in tumor progression and metastasis. It may regulate cell migration and invasion, potentially contributing to cancer cell dissemination.
ARHGAP36 has been implicated in several signaling pathways, including the Rho GTPase signaling pathway and the NMDA receptor signaling pathway. It may act as a modulator or downstream effector of these pathways, contributing to their overall cellular effects.
Customer Reviews (10)
Write a reviewThe ARHGAP36 protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.
The technical support provided by the manufacturer is invaluable in overcoming experimental hurdles and optimizing the utilization of ARHGAP36 protein.
In addition to providing impeccable protein quality, the manufacturer offers excellent technical support that can effectively address any challenges I may encounter during my research.
Another crucial aspect where the manufacturer excels is their efficient supply chain management.
Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.
Their knowledgeable and responsive team of experts is readily available to provide guidance, troubleshooting assistance, and answer any inquiries or concerns I may have.
The ARHGAP36 protein offered by the manufacturer is of exceptional quality, making it an ideal choice to fulfill my experimental needs.
Furthermore, the ARHGAP36 protein has demonstrated great utility in protein electron microscopy structure analysis.
The ARHGAP36 protein's reliability and ease of use have made it an essential component of my structural investigations.
I highly recommend the ARHGAP36 protein for a wide range of research applications.
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