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ARHGAP8

  • Official Full Name

    Rho GTPase activating protein 8

  • Synonyms

    3110043J09Rik;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARHGAP8-2703H Recombinant Human ARHGAP8 Protein, His-tagged E.coli His
Human ARHGAP8-2702H Recombinant Human ARHGAP8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ARHGAP8-1232H Recombinant Human ARHGAP8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse ARHGAP8-1881M Recombinant Mouse ARHGAP8 Protein Mammalian Cell His
Mouse Arhgap8-1688M Recombinant Mouse Arhgap8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ARHGAP8-687M-B Recombinant Mouse ARHGAP8 Protein Pre-coupled Magnetic Beads HEK293
Mouse ARHGAP8-687M Recombinant Mouse ARHGAP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ARHGAP8-4499C Recombinant Chicken ARHGAP8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARHGAP8 Related Articles

ARHGAP8 involved in several pathways and played different roles in them. We selected most pathways ARHGAP8 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rho GTPase cycleFAM13A;ARHGAP31;PLEKHG2;FGD4;ARHGAP12B;STARD13;ARHGAP4;ARHGAP44;CHN1
Signal TransductionRGS17;CRABP1B;RBP4;OXGR1A.3;DHRS3A;DLC1;CD97;TAGAPA;RDH12
Signaling by Rho GTPasesARHGAP9;ARAP2;DEPDC7;ARHGAP25;FGD2;DEPDC1B;RTKN;ARHGAP17A;PRC1B

ARHGAP8 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP8 itself. We selected most functions ARHGAP8 had, and list some proteins which have the same functions with ARHGAP8. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityRGS11;CDC42EP1B;NF1;ARHGAP4A;JUN;RASA3;ARHGAP33;FAM13A;ARHGDIA

ARHGAP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP8.

Navarrete-Perea, J; Moguel, B; et al. Identification and quantification of host proteins in the vesicular fluid of porcine Taenia solium cysticerci. EXPERIMENTAL PARASITOLOGY 143:11-17(2014).
Saravanan, C; Liu, FT; et al. Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on alpha 3 beta 1 integrin. JOURNAL OF CELL SCIENCE 122:3684-3693(2009).
  • Q&As
  • Reviews

Q&As (22)

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Does ARHGAP8 have any implications in neurodegenerative diseases? 03/09/2023

Although not extensively studied, recent research indicates the involvement of ARHGAP8 in neurodegenerative diseases. ARHGAP8 expression has been found to be altered in neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. Furthermore, dysregulation of Rho GTPase pathways, which are modulated by ARHGAP8, has been implicated in the pathogenesis of these diseases. However, more research is needed to fully understand the role of ARHGAP8 in neurodegeneration.

Can post-translational modifications regulate ARHGAP8 activity? 02/13/2023

Yes, post-translational modifications can regulate ARHGAP8 activity. Phosphorylation of ARHGAP8 has been shown to modulate its activity and subcellular localization. For example, phosphorylation by protein kinase C (PKC) has been reported to enhance ARHGAP8 activity. Other post-translational modifications, such as acetylation or ubiquitination, may also exist, but their specific roles have not been extensively investigated. Further research is needed to uncover additional post-translational modifications and their effects on ARHGAP8.

Is ARHGAP8 involved in any other diseases or disorders besides cancer? 02/12/2022

While research on ARHGAP8 is still ongoing, studies have suggested its involvement in other diseases and disorders. For instance, ARHGAP8 has been implicated in neurodevelopmental disorders like autism spectrum disorder. Altered ARHGAP8 expression has been observed in the brains of individuals with autism, and animal models lacking ARHGAP8 exhibit behavioral deficits resembling autism-like phenotypes. Additionally, ARHGAP8 has been found to be associated with schizophrenia and other psychiatric disorders. Further research is necessary to fully understand the role of ARHGAP8 in these disorders and to determine its potential as a therapeutic target.

Is ARHGAP8 expressed in specific tissues or organs? 07/10/2021

ARHGAP8 is expressed in various tissues and organs, albeit at different levels. It is found in the brain, heart, lung, liver, kidney, and many other tissues. Within the brain, ARHGAP8 expression is particularly prominent in regions involved in neuronal development and synaptic plasticity, suggesting an important role in brain function and development.

Are there any known regulatory mechanisms for ARHGAP8 expression or activity? 02/25/2021

The regulatory mechanisms for ARHGAP8 expression and activity are not well-characterized. However, studies have suggested that ARHGAP8 expression can be influenced by various signaling pathways, such as the Wnt/β-catenin signaling pathway in colorectal cancer. Additionally, post-translational modifications, such as phosphorylation, may regulate ARHGAP8 activity. Further research is needed to unravel the complete regulatory network governing ARHGAP8.

Are there any known interactors or binding partners of ARHGAP8? 08/21/2020

Several proteins have been identified as potential interactors or binding partners of ARHGAP8. For example, ARHGAP8 has been shown to interact with αvβ3 integrin at focal adhesions, where it regulates cell migration. It can also bind to other Rho GTPases, such as RhoC, and modulate their activity. Additionally, ARHGAP8 has been reported to interact with other proteins involved in cell signaling and cytoskeletal dynamics, such as paxillin and α-actinin. However, the full extent of ARHGAP8 interactors and their functional implications is still being investigated.

How does ARHGAP8 regulate Rho GTPase signaling pathways? 07/13/2020

ARHGAP8 acts as a GTPase-activating protein (GAP) for Rho GTPases, such as RhoA, Rac1, and Cdc42. These GTPases are molecular switches that control various cellular processes by cycling between an active GTP-bound state and an inactive GDP-bound state. ARHGAP8 promotes the hydrolysis of GTP to GDP, inactivating the GTPases and inhibiting their downstream signaling.

Does ARHGAP8 have any physiological functions outside of cancer and neurodevelopmental disorders? 05/11/2020

While ARHGAP8's roles in cancer and neurodevelopmental disorders have been studied more extensively, emerging evidence suggests that it may have additional physiological functions. For example, ARHGAP8 has been identified as a key regulator of dendritic spine development and synaptic plasticity in neurons. It interacts with Shank3, a scaffolding protein critical for the formation and maintenance of synapses, suggesting a role in synaptic function and neuronal connectivity. Furthermore, ARHGAP8 has been implicated in epithelial cell barrier function and wound healing. However, further research is needed to unravel the full extent of ARHGAP8's physiological functions in various cell types and tissues.

Is ARHGAP8 involved in immune cell function? 09/15/2019

The role of ARHGAP8 in immune cell function is not well-studied. However, some studies suggest its potential involvement in regulating immune cell migration and immune response. ARHGAP8 may modulate the activity of Rho GTPases in immune cells, thereby influencing processes such as adhesion, migration, and antigen presentation. Further research is needed to fully understand the contributions of ARHGAP8 to immune cell function.

Can ARHGAP8 be targeted for therapeutic purposes in cancer treatment? 08/06/2019

ARHGAP8 has been implicated in the regulation of cellular processes that are dysregulated in cancer, such as cell migration and invasion. Studies have shown that ARHGAP8 expression is altered in certain types of cancer, suggesting its potential as a therapeutic target. For example, in hepatocellular carcinoma (HCC), ARHGAP8 has been found to be upregulated and associated with tumor progression. Inhibition of ARHGAP8 expression or activity has been shown to suppress HCC cell migration and invasion. However, more research is needed to fully understand the role of ARHGAP8 in cancer and to develop targeted therapies specifically targeting this protein.

Can ARHGAP8 activity be modulated pharmacologically? 07/04/2019

While there have been no specific pharmacological inhibitors or activators developed for ARHGAP8 to date, targeting the activity of ARHGAP8 is a potential therapeutic approach under investigation. Several strategies could potentially modulate ARHGAP8 activity. For example, small molecules could be designed to interact with ARHGAP8 and either inhibit or activate its GTPase-activating activity towards Rho GTPases. Additionally, targeting the signaling pathways or proteins involved in ARHGAP8 regulation or interaction could indirectly influence ARHGAP8 activity. However, these approaches are still hypothetical, and more research is necessary to develop specific pharmacological modulators of ARHGAP8 activity.

Does ARHGAP8 have any roles in cancer? 05/25/2019

The role of ARHGAP8 in cancer is not well-documented, but emerging evidence suggests its involvement in tumor progression and metastasis. ARHGAP8 has been found to be upregulated in certain cancer types and is associated with increased cell migration and invasion. Further research is needed to fully understand the contributions of ARHGAP8 to cancer development and progression.

Are there any small molecule inhibitors or activators of ARHGAP8? 12/30/2018

Currently, there are no well-established small molecule inhibitors or activators specifically targeting ARHGAP8. However, compounds that target Rho GTPases or modulate Rho GTPase signaling could indirectly affect the activity of ARHGAP8. Development of specific ARHGAP8 modulators is an area of interest that requires further research.

Are there any known genetic variants or mutations in ARHGAP8 associated with disease susceptibility? 11/07/2018

While there have been studies linking ARHGAP8 gene variations with neurodevelopmental disorders like autism spectrum disorder, specific disease-associated genetic variants or mutations in ARHGAP8 have not been extensively reported thus far. As research continues to explore the genetic basis of various diseases, it is possible that specific disease-associated mutations in ARHGAP8 may be identified.

Can ARHGAP8 be used as a biomarker for any diseases? 04/06/2018

ARHGAP8 has not yet been established as a widely accepted biomarker for any specific diseases. However, studies have shown altered expression of ARHGAP8 in certain conditions, including cancer and neurodevelopmental disorders. Further research is needed to determine the diagnostic or prognostic potential of ARHGAP8 as a biomarker and to identify specific diseases or conditions where its expression patterns could be clinically relevant.

What are the known interactions of ARHGAP8 with other proteins? 12/18/2017

ARHGAP8 interacts with multiple proteins, including Rho GTPases such as RhoA, Rac1, and Cdc42, through its Rho-GAP domain. It also interacts with actin-binding proteins, such as alpha-actinin and cofilin, and with several components of the microtubule cytoskeleton. These interactions allow ARHGAP8 to modulate cytoskeletal organization and dynamics.

Are there any animal models available to study ARHGAP8? 12/12/2017

As of now, there are no specific animal models created solely to study ARHGAP8. However, ARHGAP8 may be studied using knockout or knockdown models where the gene is suppressed or deleted. These models allow researchers to assess the impact of ARHGAP8 loss-of-function on physiological and pathological processes in vivo. Such animal models, including mice and zebrafish, can provide valuable insights into the role of ARHGAP8 in development, disease, and behavior.

Are there any drugs or targeted therapies that specifically target ARHGAP8? 08/24/2017

Currently, there are no specific drugs or targeted therapies available that specifically target ARHGAP8. However, as more research uncovers the role of ARHGAP8 in diseases and disorders, targeting this protein or its associated pathways may present potential therapeutic opportunities in the future. Understanding the precise functions of ARHGAP8 and its interactions with other signaling molecules may lead to the development of targeted therapies for specific conditions involving dysregulation of ARHGAP8.

Does ARHGAP8 play a role in neuronal development or function? 07/07/2017

While the function of ARHGAP8 in neuronal development and function has not been extensively studied, there is evidence suggesting its involvement. ARHGAP8 interacts with components of the neuronal cytoskeleton and has been implicated in regulating neurite outgrowth. Additionally, variations in the ARHGAP8 gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder. Further research is needed to elucidate the precise roles of ARHGAP8 in neuronal development and function.

What are the downstream signaling pathways affected by ARHGAP8? 07/04/2017

The downstream signaling pathways affected by ARHGAP8 are still being studied and characterized. However, based on current evidence, it is known that ARHGAP8 mainly targets Rho GTPases, particularly RhoA, Rac1, and Cdc42. By acting as a GTPase-activating protein (GAP), ARHGAP8 promotes the hydrolysis of GTP to GDP in these Rho GTPases, thereby inactivating them and modulating downstream signaling events. Rho GTPases are involved in numerous cellular processes, including actin cytoskeleton organization, cell adhesion, cell migration, and cell proliferation. By regulating the activity of these Rho GTPases, ARHGAP8 likely influences these processes and potentially affects multiple downstream signaling cascades.

Is ARHGAP8 linked to any signaling pathways? 12/16/2016

ARHGAP8 is known to interact with multiple signaling pathways, including the Wnt/β-catenin pathway, which regulates various cellular processes during development and disease. ARHGAP8 is believed to interact with β-catenin and modulate its activity, impacting downstream signaling events. Additionally, ARHGAP8 is involved in Rho GTPase signaling pathways, which play vital roles in cytoskeletal organization and cell migration. Further research is needed to uncover additional signaling pathways and proteins that interact with ARHGAP8.

Are there any diseases or disorders associated with mutations in the ARHGAP8 gene? 06/17/2016

Although mutations in the ARHGAP8 gene have not been extensively linked to specific diseases or disorders, variations in the gene have been associated with neurodevelopmental disorders like autism spectrum disorder (ASD) and intellectual disability. Additionally, dysregulation of ARHGAP8 expression has been observed in certain types of cancer, indicating its potential involvement in tumorigenesis and tumor progression.

Customer Reviews (8)

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Reviews
04/26/2023

    Their team of experts is readily available to address any queries or concerns I may have regarding the ARHGAP8 protein.

    08/14/2022

      Their team of experts is readily available to address any concerns or queries I may have regarding the ARHGAP8 protein.

      12/10/2021

        This reliable and punctual supply enables me to proceed with my experiments without unnecessary delays, ensuring an efficient research process.

        12/06/2021

          Securing a protein of exceptional quality is crucial to meet the demands of my experiments, and I am confident that the ARHGAP8 protein offered by the manufacturer will fulfill my requirements.

          04/03/2019

            the ARHGAP8 protein, combined with the manufacturer's outstanding technical support and commitment to delivering high-quality products, presents an excellent opportunity for my research.

            05/10/2017

              The ARHGAP8 protein offered by the manufacturer excels in its quality and is an excellent match for my experimental requirements.

              08/27/2016

                With their meticulous documentation and support, I am confident that my utilization of the ARHGAP8 protein in clinical trials will meet all necessary regulations and guidelines.

                05/16/2016

                  Whether it's troubleshooting guidance, experimental design suggestions, or elucidating optimal storage conditions, their expertise can significantly accelerate the progress of my trials.

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