|Official Full Name||ATPase, H+ transporting, lysosomal V0 subunit a4|
|Background||This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.|
|Synonyms||ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4; ATP6N1B, ATP6N2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1B , ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 , ATPase, H+ transport|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ATP6V0A4 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Oxidative phosphorylation||MT-ATP6; NDUFS4; NDUFA1; ATP12A; NDUFV1; ATP6V1B1; ATP6V0D1; COX7A3; ATP6V1G2; COX7B2|
|Metabolic pathways||POLR2H; PDHB; ACY1; IMPDH2; POLA2; DUT; PGAM1B; PIGF; B4GALT2; BCAT2|
|Lysosome||AP3B2; CTSK; ATP6V1H; CTSSB.1; AP3S1; FAM49BA; ARSG; CTSA; TCEAL4; CD164|
|Phagosome||SEC61A1; HLA-DRB1; RAC1A; HLA-DPA1; TLR2; ATP6V1C1; ITGAM; PIKFYVE; RAB5AB; TUBA4L|
|Synaptic vesicle cycle||RAB3A; ATP6V0C; STXBP1; CPLX2; ATP6V1E1; ATP6V1C2; ATP6V1F; CPLX4; ATP6V1A; ATP6V0A4|
|Collecting duct acid secretion||ATP6V0E; ATP6V0C; ATP6V1D; TCIRG1; SLC4A1; ATP4B; ATP6V0A4; ATP6V1E1; ATP6V0E2; ATP6V1B2|
|Vibrio cholerae infection||KDELR3; ATP6V1B2; ATP6V1F; ACTG1; PRKACB; TJP2; ATP6V0A4; PLCG1; MUC2; ACTB|
|Epithelial cell signaling in Helicobacter pylori infection||F11R; ATP6V1A; MAPK9; PLCG1; PTPN11; IKBKB; CXCR1; ATP6V0A1; GIT1; MAPK13|
|Tuberculosis||Casp3; MAPK10; CD209; FCGR4; CAP18; MAPK9; CALM2; FCER1G; CAMK2G; FCGR2C|
|Rheumatoid arthritis||HLA-DPA1; IL11; Ctsl; ATP6V0D2; H2-AB1; MMP1A; TNFSF13B; ATP6V1H; ATP6V1E2; HLA-DRB4|
ATP6V0A4 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A4 itself. We selected most functions ATP6V0A4 had, and list some proteins which have the same functions with ATP6V0A4. You can find most of the proteins on our site.
|ATPase binding||DNAJC10; ESR1; EZR; SDF2L1; ALDOB; PKD2; ATP1B1; ATP6V0A2; DRD1; SVIP|
|protein binding||TFDP2; EFTUD2; PIH1D2; DAAM1; TBK1; PLEKHN1; KCTD17; FAM49B; PAWR; CHN2|
|proton-transporting ATPase activity, rotational mechanism||ATP6V1E2; ATPV0E2; ATP5A1; ATP6V0E2; ATP5C1; ATP6V0A2; ATP6V0CB; ATP6V1E1B; ATP6V0E1; ATP6V0A1A|
ATP6V0A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A4.