ATP6V0A4 Protein, ATPase, H+ transporting, lysosomal V0 subunit a4


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Official Full Name ATPase, H+ transporting, lysosomal V0 subunit a4
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
Synonyms ATP6V0A4; ATPase, H+ transporting, lysosomal V0 subunit a4; ATP6N1B, ATP6N2, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1B , ATPase, H+ transporting, lysosomal V0 subunit a isoform 4 , ATPase, H+ transport
    • Species :
    • Chicken
    • Human
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP6V0A4-2992H Recombinant Human ATP6V0A4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ATP6V0A4-746H Recombinant Human ATP6V0A4 Mammalian Cell His
    Chicken ATP6V0A4-3599C Recombinant Chicken ATP6V0A4 Mammalian Cell His

    ATP6V0A4 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A4 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation MT-ATP6; NDUFS4; NDUFA1; ATP12A; NDUFV1; ATP6V1B1; ATP6V0D1; COX7A3; ATP6V1G2; COX7B2
    Metabolic pathways POLR2H; PDHB; ACY1; IMPDH2; POLA2; DUT; PGAM1B; PIGF; B4GALT2; BCAT2
    Lysosome AP3B2; CTSK; ATP6V1H; CTSSB.1; AP3S1; FAM49BA; ARSG; CTSA; TCEAL4; CD164
    Synaptic vesicle cycle RAB3A; ATP6V0C; STXBP1; CPLX2; ATP6V1E1; ATP6V1C2; ATP6V1F; CPLX4; ATP6V1A; ATP6V0A4
    Collecting duct acid secretion ATP6V0E; ATP6V0C; ATP6V1D; TCIRG1; SLC4A1; ATP4B; ATP6V0A4; ATP6V1E1; ATP6V0E2; ATP6V1B2
    Vibrio cholerae infection KDELR3; ATP6V1B2; ATP6V1F; ACTG1; PRKACB; TJP2; ATP6V0A4; PLCG1; MUC2; ACTB
    Epithelial cell signaling in Helicobacter pylori infection F11R; ATP6V1A; MAPK9; PLCG1; PTPN11; IKBKB; CXCR1; ATP6V0A1; GIT1; MAPK13
    Tuberculosis Casp3; MAPK10; CD209; FCGR4; CAP18; MAPK9; CALM2; FCER1G; CAMK2G; FCGR2C
    Rheumatoid arthritis HLA-DPA1; IL11; Ctsl; ATP6V0D2; H2-AB1; MMP1A; TNFSF13B; ATP6V1H; ATP6V1E2; HLA-DRB4

    ATP6V0A4 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A4 itself. We selected most functions ATP6V0A4 had, and list some proteins which have the same functions with ATP6V0A4. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding DNAJC10; ESR1; EZR; SDF2L1; ALDOB; PKD2; ATP1B1; ATP6V0A2; DRD1; SVIP
    protein binding TFDP2; EFTUD2; PIH1D2; DAAM1; TBK1; PLEKHN1; KCTD17; FAM49B; PAWR; CHN2
    proton-transporting ATPase activity, rotational mechanism ATP6V1E2; ATPV0E2; ATP5A1; ATP6V0E2; ATP5C1; ATP6V0A2; ATP6V0CB; ATP6V1E1B; ATP6V0E1; ATP6V0A1A

    ATP6V0A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A4.

    Nagara, M; Voskarides, K; et al. A novel splice-site mutation in ATP6V0A4 gene in two brothers with distal renal tubular acidosis from a consanguineous Tunisian family. JOURNAL OF GENETICS 93:859-863(2014).
    Zeinali, F; Mohseni, M; et al. Investigation of ATP6V1B1 and ATP6V0A4 genes causing hereditary hearing loss associated with distal renal tubular acidosis in Iranian families. JOURNAL OF LARYNGOLOGY AND OTOLOGY 128:1056-1059(2014).

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