|Official Full Name||ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H|
|Background||This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit.|
|Synonyms||ATP6V1H; ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H; V-type proton ATPase subunit H; CGI 11; SFD; SFDalpha; SFDbeta; vacuolar ATP synthase subunit H; VMA13; CGI11; EC 126.96.36.199; MSTP042; NBP1; Nef binding protein 1; Nef-binding protein 1; Protein VMA13 homolog; V ATPase subunit H; V-ATPase 50/57 kDa subunits; V-ATPase subunit H; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD; VATH_HUMAN; OTTHUMP00000226227; OTTHUMP00000226228; OTTHUMP00000226253; OTTHUMP00000226254; V-ATPase H subunit; vacuolar ATPase subunit H; vacuolar proton pump H subunit; CGI-11|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ATP6V1H involved in several pathways and played different roles in them. We selected most pathways ATP6V1H participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Oxidative phosphorylation||NDUFB3; NDUFB1; ATP6V0D1; NDUFA6; SDHB; ATP5IA; COX5B2; ATP6V1G1; ATP6AP1B; NDUFS4|
|Metabolic pathways||ST8SIA5; ATP5E; UGP2; AMY2A3; DPYDB; PPAP2B; CYP3A25; LSM1; ANPEP; PCCA|
|Lysosome||AP4S1; NAGA; GBA; CLN5; ARSG; LAPTM4B; ACP5B; NEU1; SLC11A1; NAPSA|
|Phagosome||HLA-DMA; HLA-DRB4; ATP6V0C; FCGR2B; ATP6V0D2; HLA-DRA; CD209; STX12; SCARB1; SEC22B|
|Synaptic vesicle cycle||ATP6V0A4; CPLX3; VAMP2; ATP6V0D1; ATP6V1C2; NSF; SLC17A8; ATP6V1A; UNC13A; ATP6V1B1|
|Vibrio cholerae infection||PDIA4; ATP6V0D1; ATP6AP1; ATP6V0A1; ACTG1; ATP6V0A2; ATP6V0C; ATP6V0B; ATP6V1D; KDELR1|
|Epithelial cell signaling in Helicobacter pylori infection||ATP6V1C2; MAP3K14; LYN; NFKBIA; IKBKG; ATP6V1B1; CXCR1; GIT1; NFKB1; RELA|
|Tuberculosis||RHOA; CASP9; NOS2; IRAK4; LAMP1; IFNA13; MAPK3; CD209C; TLR2; HLA-DMB|
|Rheumatoid arthritis||MMP3; CXCL12; LTB; TLR2; HLA-DOB; IL18; ATP6V1F; TLR4; CTLA4; ITGB2L|
ATP6V1H has several biochemical functions, for example, contributes_to ATPase activity, enzyme regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1H itself. We selected most functions ATP6V1H had, and list some proteins which have the same functions with ATP6V1H. You can find most of the proteins on our site.
|contributes_to ATPase activity||ATP6V1H; RFC3; ATP1A2; ATP1B1; ATP5C1; ATP5J; MSH2; RUVBL2; ATP5E; ABCA7|
|enzyme regulator activity||DPM2; SEPT2; PPP1R7; DCP1B; PSMD1; BRCC3; ATP6V1H; GCLM; CPN2; RGN|
|protein binding||CNGA1; ARHGEF15; ITGA2; GRAMD3; LOXL4; FGFR1; SLC2A4; TCEB3B; GET4; NOLC1|
|proton-transporting ATPase activity, rotational mechanism||ATP6V0A1; ATP6V0A4; ATP6V0C; ATP6V1B2; TCIRG1; ATPV0E2; ATP5E; ATP6V1E1; ATP6V1C1; ATP6V1E1B|
ATP6V1H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1H here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1H.
PTP4A3; MYC; PHLDA3; ETHE1; SOX9; yjjK; TANK; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; ATP6V1A