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AIMP1

  • Official Full Name

    aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

  • Overview

    The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.
  • Synonyms

    AIMP1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; p43; EMAP2; SCYE1; EMAPII; aminoacyl tRNA synthase complex-interacting multifunctional protein 1; OTTHUMP00000161877; OTTHUMP00000161878; OTTHUMP00000219673; ARS-interacting multifunctional protein 1; endothelial monocyte-activating polypeptide 2; multisynthase complex auxiliary component p43; endothelial-monocyte activating polypeptide II; multisynthetase complex auxiliary component p43; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating); AIMP1/p43; 9830137A06Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Human
  • Human Cell
  • Mammalian Cell
  • GST
  • His
  • N/A
  • N
  • Strep II
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AIMP1 Related Research Area

AIMP1 involved in several pathways and played different roles in them. We selected most pathways AIMP1 participated on our site, such as Cytosolic tRNA aminoacylation, Gene Expression, tRNA Aminoacylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with AIMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytosolic tRNA aminoacylationFARSB;AIMP2;AARS;DARS;KARS;AIMP1;MADD;EEF1E1
Gene ExpressionLAMTOR1;ZBTB8OS;TRMT11;ZNF689;MADD;WDR4;JUNB;QTRTD1;CDKAL1
tRNA AminoacylationDARS;FARSB;WARS2;AIMP1;AARS;MADD;KARS;FARS2;EARS2

AIMP1 has several biochemical functions, for example, GTPase binding, cytokine activity, NOT methionine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AIMP1 itself. We selected most functions AIMP1 had, and list some proteins which have the same functions with AIMP1. You can find most of the proteins on our site.

Function Related Protein
GTPase bindingGNB3;GNB2;IARS;STOML2;ENO1;AIMP1;VPS41;BNIP3;SPTBN1
cytokine activityWNT2;LTA;PRL7D1;CMTM6;LIF;CMTM2;IFNA10;Gm13290;BMP1
NOT methionine-tRNA ligase activityLARS;AIMP1
protein bindingFOXC1;WIPI2;BSX;RNF24;LDHAL6B;GCC1;TRAF6;FRS2;TBX18
protein homodimerization activityMAOB;UGT1A3;CHMP1A;NTRK2;GLIPR2;CEBPA;Il6ra;FAP;CCBL1
tRNA bindingAARS;TRMU;AIMP1;XPOT;METTL1;TRMT1L;YARS2;TRMT11;NSUN2

AIMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AIMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AIMP1.

gag; AIMP2; TSNAX; MCC; HLA-B; ARF6; IKBKE; FTSJ1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; midostaurin; ssrna_ug

  • Q&As
  • Reviews

Q&As (11)

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How does AIMP1 affect cellular metabolism? 05/12/2023

AIMP1 has been shown to affect cellular metabolism by regulating the activity of several metabolic enzymes. One of the known mechanisms of AIMP1-mediated metabolic regulation involves the inhibition of AMP-activated protein kinase (AMPK), a key regulator of cellular metabolism that responds to changes in energy balance. AIMP1 binds to and inhibits AMPK, leading to altered glucose and lipid metabolism in cells.

Can AIMP1 be used as a diagnostic or prognostic marker for disease? 07/08/2022

AIMP1 has potential as a diagnostic or prognostic marker for certain diseases, particularly cancer. Its expression has been shown to be increased in several types of cancer, and high levels of AIMP1 expression have been associated with poor prognosis in some cancers. Additionally, AIMP1 expression has been suggested as a biomarker for early detection and progression monitoring of certain cancers.

Can AIMP1 protein be used as a therapeutic target? 05/04/2022

AIMP1 has been proposed as a potential therapeutic target for various diseases, including cancer and neurological disorders. However, more research is needed to fully understand the therapeutic potential of targeting AIMP1.

What diseases are associated with mutations in the AIMP1 gene? 09/28/2020

Mutations in the AIMP1 gene have been associated with various diseases, including rare neurological disorders such as leukodystrophies and movement disorders. Mutations in this gene have also been linked to susceptibility to certain types of cancers such as colorectal cancer and gastric cancer.

How is AIMP1 involved in neurological disorders? 04/08/2020

Mutations in AIMP1 have been linked to several neurological disorders, including Charcot-Marie-Tooth disease type 2D, hereditary sensory and autonomic neuropathy type 2, and peripheral neuropathy with or without agenesis of the corpus callosum. AIMP1 is thought to play a role in the maintenance of peripheral nerves, and mutations in this gene can lead to peripheral nerve degeneration.

How is AIMP1 regulated in the cell? 10/03/2019

AIMP1 protein expression and function are regulated by various mechanisms, including transcriptional regulation, post-transcriptional regulation, and post-translational modifications. For example, AIMP1 expression can be regulated by various transcription factors, such as PPARγ, NF-κB, and YY1. In addition, AIMP1 protein stability and activity can be regulated by phosphorylation, acetylation, and ubiquitination.

Can AIMP1 be used as a therapeutic target in autoimmune diseases? 07/03/2017

AIMP1 has been suggested as a potential therapeutic target in autoimmune diseases such as rheumatoid arthritis. Inhibition of AIMP1 has been shown to reduce the severity of arthritis in mouse models, possibly by reducing inflammation and modulating immune cell differentiation. However, more research is needed to determine the efficacy and safety of targeting AIMP1 for therapeutic purposes in humans.

How is AIMP1 regulated at the transcriptional level? 12/10/2016

The regulation of AIMP1 expression is complex and not yet fully understood. Multiple transcription factors, including NF-κB, p53, and c-Myc, have been shown to regulate AIMP1 expression by binding to its promoter region. In addition, epigenetic modifications, such as DNA methylation and histone acetylation, can also affect AIMP1 expression. Other factors, such as microRNA, can also regulate AIMP1 expression at the post-transcriptional level.

Are there any drugs targeting AIMP1 protein currently in development? 01/21/2016

There are currently no drugs specifically targeting AIMP1 protein in development. But given the growing interest in AIMP1 as a therapeutic target, it is possible that such drugs may be developed in the future.

What techniques are used to study AIMP1 protein? 03/16/2015

Various techniques can be used to study AIMP1 protein, including Western blot, immunofluorescence, co-immunoprecipitation, and mass spectrometry. These techniques can be used to study AIMP1 protein expression, localization, and protein-protein interactions.

Are there any drugs that target AIMP1? 01/11/2015

Currently, there are no drugs that specifically target AIMP1. However, AIMP1 has been suggested as a potential therapeutic target for certain diseases, including cancer, and there is ongoing research to develop drugs that can modulate the activity of AIMP1. For example, small molecule inhibitors of AIMP1 have been identified and shown to have potential as cancer therapeutics in preclinical studies.

Customer Reviews (4)

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Reviews
09/14/2021

    heir dedicated team of experts is readily available to address any challenges or questions that may arise during my experiments.

    06/19/2016

      Their profound knowledge and guidance provide invaluable assistance in overcoming hurdles and optimizing my research protocols, ensuring a seamless and efficient workflow.

      03/12/2016

        Its exceptional purity, stability, and functionality make it a reliable tool for conducting precise and reliable research, opening up new avenues for exploration and discovery.

        04/16/2015

          What truly sets this protein apart is the manufacturer's unwavering commitment to delivering exceptional technical support.

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