Recombinant Full Length Human AIMP1 Protein, N-His-tagged

• Cat.No.: AIMP1-18HFL
• Product Overview: Purified recombinant protein of Human aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol.
• Molecular Mass: 34.2 kDa
• AA Sequence: A DNA sequence encoding human full-length AIMP1
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80 centigrade.
• Concentration: >0.05 μg/μL as determined by microplate BCA method.
• Use/Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 [ Homo sapiens (human) ]
• Official Symbol: AIMP1
• Synonyms: AIMP1; aminoacyl tRNA synthetase complex interacting multifunctional protein 1; EMAP2; EMAPII; HLD3; p43; SCYE1
• Gene ID: 9255
• mRNA Refseq: NM_004757.4
• Protein Refseq: NP_004748.2
• MIM: 603605
• UniProt ID: Q12904