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BLNK

  • Official Full Name

    B cell linker

  • Overview

    The B cell linker protein BLNK (also referred to as B cell adaptor containing Src homology 2 domain - BASH - or, SLP-65), is crucial for B cell antigen receptor (BCR)-mediated activation, proliferation, and differentiation of B cells. BLNK represents a ce
  • Synonyms

    BLNK; B cell linker; B-cell linker protein; lymphocyte antigen 57; cytoplasmic adapter protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; src homology 2 domain-containing leukocyte protein of 65 kDa; Bca; BASH; Ly57; Ly-57; Lyw-57; SLP-65;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BLNK-406H Recombinant Human BLNK Protein, His-tagged E.coli His
Human BLNK-10240H Recombinant Human BLNK, GST-tagged E.coli GST 1-456a.a.
Human BLNK-244H Recombinant Human BLNK Protein, GST-tagged Wheat Germ GST
Human BLNK-6875H Active Recombinant Human BLNK protein, His-tagged HEK293 His Met1-Ser456
Human BLNK-245H Recombinant Human BLNK Protein, GST-tagged Wheat Germ GST
Human BLNK-3475H Recombinant Human BLNK, His-tagged E.coli His
Human BLNK-26279TH Recombinant Human BLNK Protein, His-tagged E.coli His 1-456aa
Human BLNK-1858HCL Recombinant Human BLNK cell lysate Human Cell N/A
Human BLNK-1426H Recombinant Human BLNK Protein (Ser65-Thr314), N-His tagged E.coli N-His Ser65-Thr314
Human BLNK-1709HF Recombinant Full Length Human BLNK Protein, GST-tagged In Vitro Cell Free System GST 456 amino acids
Human BLNK-0735H Recombinant Human BLNK Protein (Met1-Ser456), C-His tagged E.coli C-His Met1-Ser456
Mouse BLNK-2417M Recombinant Mouse BLNK Protein Mammalian Cell His
Mouse BLNK-1042M-B Recombinant Mouse BLNK Protein Pre-coupled Magnetic Beads HEK293
Mouse BLNK-1042M Recombinant Mouse BLNK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BLNK-988R Recombinant Rat BLNK Protein Mammalian Cell His
Rat BLNK-646R Recombinant Rat BLNK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat BLNK-646R-B Recombinant Rat BLNK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish BLNK-12102Z Recombinant Zebrafish BLNK Mammalian Cell His
Chicken BLNK-6470C Recombinant Chicken BLNK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BLNK Related Articles
  • BLNK Related Research Area

BLNK involved in several pathways and played different roles in them. We selected most pathways BLNK participated on our site, such as NF-kappa B signaling pathway, Osteoclast differentiation, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLNK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayTRAF2;MAP3K7IP3;LY96;DDX58;CCL13;BIRC2;Ccl21a;PRKCB;CARD11
Osteoclast differentiationLCP2;TNFSF11;NCF1;IFNAR2;CYBB;IL1B;FCGR4;LILRA2;FOSB
B cell receptor signaling pathwayPPP3CA;PLEKHA2;MAP4K1;INPP5D;ARPC5;PDPK1A;STAP1;PIK3AP1;BCL10
Primary iCD79A;IL2RG;CD8A;CD19;RAG1;BLNK;ICOS;RFX5;ORAI1
nodeficiencyCD8B;CD8A;TNFRSF13B;ICOS;RAG1;RFXANK;LCK;CD79A;IGLL1

BLNK has several biochemical functions, for example, SH3/SH2 adaptor activity, protein binding, transmembrane receptor protein tyrosine kinase adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLNK itself. We selected most functions BLNK had, and list some proteins which have the same functions with BLNK. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activityCD28;KHDRBS1;GRAP;IRS4;SRC;SH3BGR;EPS8;SKAP2;CNTNAP1
protein bindingFBLIM1;CDK17;IMPA2;FASTKD3;RASD1;HSPBAP1;PYYA;FAM134C;FMO4
transmembrane receptor protein tyrosine kinase adaptor activityIRS1;DOK2;PIK3R1;SHC1;BLNK;FRS2;SH2B2;GAB2;STAP1

BLNK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLNK here. Most of them are supplied by our site. Hope this information will be useful for your research of BLNK.

GRB2; BTK; Grap2; SH3KBP1; CD2AP; q5zjw0_chick; ERBB2; AR

Wang, J; Sohn, H; et al. The autoinhibitory C-terminal SH2 domain of phospholipase C-gamma 2 stabilizes B cell receptor signalosome assembly. SCIENCE SIGNALING 7:-(2014).
Luger, D; Yang, YA; et al. Expression of the B-Cell Receptor Component CD79a on Immature Myeloid Cells Contributes to Their Tumor Promoting Effects. PLOS ONE 8:-(2013).
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