Recombinant Full Length Human BLNK Protein, GST-tagged
Cat.No. : | BLNK-1709HF |
Product Overview : | Human BLNK full-length ORF ( AAH18906.1, 1 a.a. - 456 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 76.9 kDa |
Protein Length : | 456 amino acids |
AA Sequence : | MDKLNKITVPASQKLRQLQKMVHDI KNNEGGIMNKIKKLKVKAPPSVPRR DYASESPADEEQQWSDDFDSDYENP DEHSDSEMYVMPAEENADDSYEPPP VEQETRPVHPALPFARGEYIDNRSS QRHSPPFSKTLPSKPSWPSEKARLT STLPALTALQKPQVPPKPKGLLEDE ADYVVPVEDNDENYIHPTESSSPPP EKAPMVNRSTKPNSSTPASPPGTAS GRNSGAWETKSPPPAAPSPLPRAGK KPTTPLKTTPVASQQNASSVCEEKP IPAERHRGSSHRQEAVQSPVFPPAQ KQIHQKPIPLPRFTEGGNPTVDGPL PSFSSNSTISEQEAGVLCKPWYAGA CDRKSAEEALHRSNKDGSFLIRKSS GHDSKQPYTLVVFFNKRVYNIPVRF IEATKQYALGRKKNGEEYFGSVAEI IRNHQHSPLVLIDSQNNTKDSTRLK YAVKVS |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | BLNK B-cell linker [ Homo sapiens ] |
Official Symbol : | BLNK |
Synonyms : | BLNK; B-cell linker; B-cell linker protein; B cell adaptor containing SH2 domain; B cell activation; B cell adapter containing a SH2 domain protein; BASH; bca; BLNK s; Ly57; SLP 65; SLP65; Src homology [SH2] domain containing leukocyte protein of 65 kD; B-cell activation; B cell linker protein; cytoplasmic adapter protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; Src homology [SH2] domain-containing leukocyte protein of 65 kD; AGM4; LY57; BLNK-S; SLP-65; MGC111051 |
Gene ID : | 29760 |
mRNA Refseq : | NM_001114094 |
Protein Refseq : | NP_001107566 |
MIM : | 604515 |
UniProt ID : | Q8WV28 |
Products Types
◆ Recombinant Protein | ||
BLNK-1042M | Recombinant Mouse BLNK Protein, His (Fc)-Avi-tagged | +Inquiry |
BLNK-646R | Recombinant Rat BLNK Protein, His (Fc)-Avi-tagged | +Inquiry |
BLNK-26279TH | Recombinant Human BLNK Protein, His-tagged | +Inquiry |
BLNK-6470C | Recombinant Chicken BLNK | +Inquiry |
BLNK-2417M | Recombinant Mouse BLNK Protein | +Inquiry |
◆ Lysates | ||
BLNK-1858HCL | Recombinant Human BLNK cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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