CACNA2D4 Protein, calcium channel, voltage-dependent, alpha 2/delta subunit 4


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Official Full Name calcium channel, voltage-dependent, alpha 2/delta subunit 4
Background This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms CACNA2D4; calcium channel, voltage-dependent, alpha 2/delta subunit 4; voltage-dependent calcium channel subunit alpha-2/delta-4; voltage-gated calcium channel alpha(2)delta-4 subunit; voltage-gated calcium channel subunit alpha-2/delta-4; RCD4
    • Species :
    • Human
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CACNA2D4-143HCL Recombinant Human CACNA2D4 lysate HEK293 N/A
    Human CACNA2D4-876H Recombinant Human CACNA2D4 Mammalian Cell His

    CACNA2D4 involved in several pathways and played different roles in them. We selected most pathways CACNA2D4 participated on our site, such as MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNA2D4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MKNK2A; HSPA1B; HSPA8; FGFR1A; MAP4K3; PRKCG; HSPA1A; FGF19; FLNB; EGFRA
    Cardiac muscle contraction COX6C; CACNA2D1; COX7B; COX5AA; CACNG7A; CACNG2A; CACNB4A; ATP1B1; RYR2; CACNB4
    Adrenergic signaling in cardiomyocytes PRKCA; PPP2R2A; PPP2R1A; ADCY9; CREB5; GNAI3; CACNG7A; RAPGEF3; ATP2B1A; BCL2A
    Oxytocin signaling pathway PRKACA; PRKCB; CAMKK2; NFATC4; PLA2G4A; PLCB1; GNAI3; MAP2K2; ELK1; CAMK2B
    Hypertrophic cardiomyopathy (HCM) TPM1; CACNG4; ITGA5; ITGA10; CACNG6; TNF; MYL3; TGFB3; ITGA2; RYR2
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA2B; ITGB4; ACTN1; ITGA5; ITGB6; SGCB; Itga10&Itgb1; CTNNA3; ITGA8; PKP2
    Dilated cardiomyopathy CACNG4; ITGA10; CACNG7; Adcy4; ITGB5; TGFB3; TPM3; PRKACA; PLN; CACNB1

    CACNA2D4 has several biochemical functions, for example, calcium channel regulator activity, metal ion binding, voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNA2D4 itself. We selected most functions CACNA2D4 had, and list some proteins which have the same functions with CACNA2D4. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel regulator activity SGK2B; Crisp4; GRM7; CACNA2D3; NRXN1; TSPAN13A; NRXN2; GRM2; SGK2A; GRM6A
    metal ion binding BMP1A; METAP1; ZNF726; CYP1D1; ADCY6; TNNI3K; CNOT4B; KLF12B; PDE4C; G2E3
    voltage-gated calcium channel activity CACNB3A; CACNA2D2; CACNB1; CACNG1A; CACNG2; RYR1; CACNG8; CACNA2D1; CACNB2B; CACNG7A

    CACNA2D4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNA2D4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNA2D4.

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