CBX4
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Official Full Name
chromobox homolog 4 -
Synonyms
CBX4;chromobox homolog 4;chromobox homolog 4 (Drosophila Pc class);E3 SUMO-protein ligase CBX4;hPC2;NBP16;NS5ATP1 binding protein 16;Pc class 2 homolog (Drosophila);PC2;Pc class 2 homolog;polycomb 2 homolog;NS5ATP1-binding protein 16;chromobox
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CBX4-10769H | Recombinant Human CBX4, GST-tagged | E.coli | Human | GST | 1-290a.a. | |
| CBX4-11764Z | Recombinant Zebrafish CBX4 | Mammalian Cells | Zebrafish | His |
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| CBX4-6210C | Recombinant Chicken CBX4 | Mammalian Cells | Chicken | His |
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| CBX4-7803HCL | Recombinant Human CBX4 293 Cell Lysate | HEK293 | Human | Non |
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| CBX4-2780HF | Recombinant Full Length Human CBX4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 290 amino acids |
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Involved Pathway
CBX4 involved in several pathways and played different roles in them. We selected most pathways CBX4 participated on our site, such as C-MYB transcription factor network,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| C-MYB transcription factor network | PPID,PRTN3,YEATS4,SMARCA2,COL1A2,CDKN1B,TRIM28,CLTA,MYB,PTCRA |
| Metabolism of proteins | TIMM17A,EEF1G,ARSD,TOMM6,TBCB,MUCL1,MAN1A2,ZNF408,SPCS3,ADAMTS10 |
| Regulation of retinoblastoma protein | BGLAP,ATF7,ELF1,SMARCB1,BRD2,GSC,CKM,MYOD1,AATF |
| Cellular Senescence | POT1,MOV10,CDK4,MAPKAPK2B,RBBP4,RBB4L,HIST1H1C,SCMH1,RNF2,CDKN2B |
| Cellular responses to stress | ULK1A,CDKN2D,EPAS1B,SUZ12,NUPL2,WIPI2,HDAC6,ATG9B,HIST4H4,LAMTOR1 |
| Post-translational protein modification | THSD7A,LMAN2,WDR85,TRAPPC6BL,DPH5,ARSI,ADAMTS5,ALG10B,NEU3,MUC21 |
| Oxidative Stress Induced Senescence | CBX8,CBX8A,PHC2,CBX6A,TNIK,SUZ12B,EED,CBX8B,RING1,RNF2 |
| SUMO E3 ligases SUMOylate target proteins | RING1,CBX8,SCMH1,NSMCE2,PHC2,SMC6,PHC3,NSMCE4A,NSMCE1,PHC1 |
Protein Function
CBX4 has several biochemical functions, for example, SUMO binding,SUMO transferase activity,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX4 itself. We selected most functions CBX4 had, and list some proteins which have the same functions with CBX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | NEURL1B,C12orf51,HERC5,NEURL3,MIB1,TRIM28,UBE2L3B,TRIM9,RNF180,MYLIPA |
| SUMO binding | USPL1,TDG,HERC2,RPS3,PML,TOLLIP,USP25 |
| protein binding | PTPRG,ANGPT2,STAC,MED31,CYB5R2,KIF27,RAB11FIP2,PRRG2,ZNF652,ADAMTSL4 |
| transcription regulatory region DNA binding | FOXA1,Arid4b,RELA,ZNF174,TOMM20A,GATA5,TCF7L1B,SERPINB1A,SALL4,CDK9 |
| enzyme binding | EIF2AK3,SUDS3,PPARG,HDAC2,CSF3,UGT1A3,GSTM1,IL6R,PAWR,SLC27A2 |
| SUMO transferase activity | MUL1,SUMO3,PIAS4,UBE2I,NSMCE2,SUMO4,SUMO1,UBE2IB,UBE2IA,TOPORS |
| single-stranded RNA binding | ZFP36,STRBP,LSM14A,IFIH1,HNRNPA1,TLR8,CBX6,POLR2GL,JMJD6,HMGB1 |
| methylated histone binding | ING5,CCDC101,SPIN1,ING2,CHD8,CDYL2,KDM4A,MSL3,RBBP5,ING3 |
| transcription corepressor activity | BRD7,CTBP2A,NR1H4,TBL1XR1,SKI,YAP1,HSF4,THRB,LOXL2,RYBP |
Interacting Protein
CBX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX4.
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