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CBX4

Official Full Name

chromobox homolog 4
Synonyms

CBX4; chromobox homolog 4; chromobox homolog 4 (Drosophila Pc class); E3 SUMO-protein ligase CBX4; hPC2; NBP16; NS5ATP1 binding protein 16; Pc class 2 homolog (Drosophila); PC2; Pc class 2 homolog; polycomb 2 homolog; NS5ATP1-binding protein 16; chromobox;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CBX4-10769H	Recombinant Human CBX4, GST-tagged	E.coli	GST	1-290a.a.	$319 / 25ug
Human	CBX4-0482H	Recombinant Human CBX4 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CBX4-7803HCL	Recombinant Human CBX4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CBX4-2780HF	Recombinant Full Length Human CBX4 Protein, GST-tagged	In Vitro Cell Free System	GST	290 amino acids	Inquiry
Zebrafish	CBX4-11764Z	Recombinant Zebrafish CBX4	Mammalian Cell	His		Inquiry
Chicken	CBX4-6210C	Recombinant Chicken CBX4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CBX4 involved in several pathways and played different roles in them. We selected most pathways CBX4 participated on our site, such as C-MYB transcription factor network, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
C-MYB transcription factor network	LECT2;PIAS3;CBX4;YEATS4;CLTA;ADA;CSF1R;CEBPA;CEBPB
Cellular Senescence	POT1;H3F3B.1;CDKN2D;HMGA1-RS1;CBX8A;CBX6A;PHC3;HIST1H1E;TERF1
Cellular responses to stress	POT1;ACD;BMI1A;HIRA;EGLN1B;EGLN2;HIST1H1D;ASF1A;HDAC6
Metabolism of proteins	SLC30A6;TRAPPC4;SENP5;CST3;SEC23IP;NANP;NAPB;NEU4;TMED10
Oxidative Stress Induced Senescence	PHC1;SCMH1;CBX8A;MINK1;SUZ12;CBX8;SUZ12A;RNF2;CBX8B
Post-translational protein modification	RNF2;SPON2;TFG;NSMCE1;ST8SIA3;OTOP2;NANP;ST6GALNAC1.2;TRAPPC6BL
Regulation of retinoblastoma protein	ATF7;ELF1;BRD2;BGLAP;AATF;GSC;SMARCB1;MYOD1;CBX4
SUMO E3 ligases SUMOylate target proteins	RNF2;SMC6;CBX8;RING1;NSMCE1;PHC2;SCMH1;SMC5;PHC3

CBX4 has several biochemical functions, for example, SUMO binding, SUMO transferase activity, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBX4 itself. We selected most functions CBX4 had, and list some proteins which have the same functions with CBX4. You can find most of the proteins on our site.

Function	Related Protein
SUMO binding	USPL1;TDG;PML;TOLLIP;HERC2;USP25;RPS3;CBX4
SUMO transferase activity	SUMO1;TOPORS;MUL1;CBX4;PIAS4;SUMO4;UBE2IA;NSMCE2;PIAS3
chromatin binding	PRDM13;NSD1;GATA2A;HDGF2;HMG20A;ZFP143;HMGB2;EOMES;PHF21A
enzyme binding	KALRN;CYP3A4;DAXX;LDB1;CYP2C8;ATG3;PARK2;CD4;BLZF1
ligase activity	DTX3;MARCH9;TTLL5;RBBP6;MARCH11;UBE3B;UBR7;HECW1B;RNF213
methylated histone binding	L3MBTL1;LOXL2;UHRF1;ING2;PHF2;TDRD3;GLYR1;MTF2;CDYL2
phosphoprotein binding	YWHAB;TRPV1;TBK1;CSNK1D;DPYSL3;SERPINB1A;PITX2;GPRIN1;FKBP4
protein binding	AMOTL2A;PYGO2;TRAM1;INO80;TRPV5;CENPW;SH3GL3;INVS;SELPLG
single-stranded RNA binding	DDX58;POLR2G;TLR8;DLX2;CNBP;A1CF;ANXA1;NXF1;JMJD6
transcription corepressor activity	SKOR2;BCOR;LMCD1;KCNIP3;BATF3;E2F7;ELK3;RELB;YWHAB
transcription regulatory region DNA binding	SOX2;TFE3;CDK9;ASH2L;IKZF4;RFX3;ATMIN;DHX36;SMAD6

CBX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBX4.

BMI1; HIF1A