cct7
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  • Official Full Name
  • chaperonin containing TCP1, subunit 7 (eta)
  • Background
  • This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6.
  • Synonyms
  • CCT7; chaperonin containing TCP1, subunit 7 (eta); T-complex protein 1 subunit eta; Ccth; Nip7 1; CCT ETA; CCT-eta; Chaperonin containing t complex polypeptide 1 eta subunit; Chaperonin containing TCP1 subunit 7 (eta); Chaperonin containing TCP1 subunit 7; HIV 1 Nef interacting protein; HIV-1 Nef-interacting protein; T complex protein 1 eta subunit; TCP-1-eta; TCPH_HUMAN; OTTHUMP00000202321; OTTHUMP00000202322; OTTHUMP00000213063; HIV-1 Nef interacting protein; chaperonin containing t-complex polypeptide 1, eta subunit; CCTETA; NIP7-1; TCP1ETA
Cat.#:CCT7-0717HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCT7 Protein, GST-Tagged
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Cat.#:CCT7-3007HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCT7 Protein, MYC/DDK-tagged
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Cat.#:CCT7-10900HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCT7, His-tagged
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Cat.#:CCT7-3029MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCT7 Protein
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Cat.#:CCT7-715RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCT7 Protein, His-tagged
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Cat.#:CCT7-3185CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCT7
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Cat.#:CCT7-9522ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCT7
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Cat.#:CCT7-313HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCT7 cell lysate
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Involved Pathway

CCT7 involved in several pathways and played different roles in them. We selected most pathways CCT7 participated on our site, such as Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCT7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Association of TriC/CCT with target proteins during biosynthesis
FBXW9; CCT4; CCT3; CCT8; CCT5; CCT7; FKBP9; TCP1; FBXW2; CCT2
Chaperonin-mediated protein folding
CCT4; CCT6A; FBXW2; VBP1; TUBB4A; PFDN5; FBXW9; FBXW4; FKBP9; CCT7
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
CCT8; PFDN4; PFDN2; CCT4; TUBA3D; VBP1; TUBA1B; TUBB4B; CCT5; CCT3
Folding of actin by CCT/TriC
CCT8; CCT6A; CCT7; TCP1; CCT3; CCT4; CCT5; CCT2
Formation of tubulin folding intermediates by CCT/TriC
TUBB4A; CCT5; TCP1; CCT6A; TUBA1B; CCT7; CCT2; CCT4; TUBB4B; CCT8
Metabolism of proteins
BCHE; ADAMTSL3; PFDN4; IGFBP5A; ST8SIA3; TIMM9; SLC25A13; PROCA; MBOAT4; PPP6C
Prefoldin mediated transfer of substrate to CCT/TriC
VBP1; CCT7; CCT6A; PFDN5; PFDN6; PFDN2; PFDN1; PFDN4
Protein folding
VBP1; PFDN1; PFDN5; CCT7; TBCE; NOP56; TBCC; KIFC3; PFDN6; ARL2

Protein Function

CCT7 has several biochemical functions, for example, ATP binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCT7 itself. We selected most functions CCT7 had, and list some proteins which have the same functions with CCT7. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NMNAT1; PRPS1; SKIV2L; CSNK1A1; DHX32A; SMC2; NIM1; ABCB7; UBE2E1; MOV10B.1
Function identical protein binding
Related Protein BIN1; IGF2R; KHDC1A; IFI203; SDF4; SERPINA1D; PHYKPL; CCL3; RABAC1; CAV1
Function protein binding
Related Protein MCCC1; HOMEZ; MIPOL1; ZMYM5; CAPNS2; ATP6V1C2; FLT3; ZNF436; DUSP12; TMEM100
Function unfolded protein binding
Related Protein DNAJA3A; DNAJB11; HSP26; PDRG1; SERPINH1; DNAJB6; RP2; HSP90AA1; TRAP1; TOR1A

Interacting Protein

CCT7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCT7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCT7.
PPP4C; PPP2CB; PPP2CA; STRN3; ILK; SSSCA1; STRN

CCT7 Related Articles

Erdmann, J; Stark, K; et al. Dysfunctional nitric oxide signalling increases risk of myocardial infarction. NATURE 504:432-+(2013).
Hirata, H; Ishinabe, S; et al. Molecular Characterization and Phylogenetic Analysis of Babesia sp NV-1 Detected from Wild American Mink (Neovison vison) in Hokkaido, Japan. JOURNAL OF PARASITOLOGY 99:350-352(2013).