CDC42

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CDC42

Official Full Name cell division cycle 42
Background The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
Synonyms CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • pstS1
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDC42-1712H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDC42-4183H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDC42-6646H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Cdc42-856M Recombinant Mouse Cdc42 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CDC42-0934H Recombinant Human CDC42 Protein, GST-Tagged Wheat Germ GST
    Human CDC42-0936H Recombinant Human CDC42 Protein, GST-pstS1-Tagged Wheat Germ GST/pstS1
    Human CDC42-1023H Recombinant Human Cell Division Cycle 42, GST-tagged E.coli GST
    Human CDC42-1024H Recombinant Human Cell Division Cycle 42 E.coli N/A
    Human CDC42-11008H Recombinant Human CDC42, GST-tagged E.coli GST
    Human CDC42-1394H Recombinant Human Cell Division Cycle 42, T7-tagged E.coli T7
    Human CDC42-1579H Recombinant Human Cell Division Cycle 42 (GTP binding protein, 25kDa), GST-tagged E.coli GST
    Human CDC42-1806H Recombinant Human CDC42, GST tagged E.coli GST
    Human CDC42-2634H Recombinant Human CDC42 protein, His-tagged E.coli His
    Human CDC42-2635H Recombinant Human CDC42 protein, GST-tagged E.coli GST
    Human CDC42-2636H Recombinant Human CDC42(T17N) protein, GST-tagged E.coli GST
    Human CDC42-2637H Recombinant Human CDC42(Q61L) protein, His-tagged E.coli His
    Human CDC42-26610TH Recombinant Human CDC42 E.coli N/A
    Human CDC42-26651TH Recombinant Human CDC42, T7 -tagged E.coli T7
    Human CDC42-7033H Recombinant Human CDC42, GST/His-tagged E.coli GST/His
    Human CDC42-7655HCL Recombinant Human CDC42 293 Cell Lysate HEK293 N/A
    Mouse CDC42-3139M Recombinant Mouse CDC42 Protein Mammalian Cell His
    Rat CDC42-1277R Recombinant Rat CDC42 Protein Mammalian Cell His
    Cynomolgus Monkey CDC42-395C Recombinant Cynomolgus CDC42 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CDC42-763R Recombinant Rhesus monkey CDC42 Protein, His-tagged Mammalian Cell His
    Chicken CDC42-6605C Recombinant Chicken CDC42 Mammalian Cell His
    Zebrafish CDC42-10904Z Recombinant Zebrafish CDC42 Mammalian Cell His
    Kit-0190 Cdc42 G-LISA Activation Assay Kit (Colorimetric) N/A
    Kit-0191 Cdc42 G-LISA Activation Assay Kit (Colorimetric) II N/A

    CDC42 involved in several pathways and played different roles in them. We selected most pathways CDC42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PDGFA; CACNB4A; MAP3K4; MAP2K7; NFATC1; BDNF; RPS6KA3B; MAP3K1; BRAF; PLA2G4AA
    Ras signaling pathway GNG7; PRKACG; PLA2G2E; NFKB1; PAK7; GNG12; GAB2; PRKACA; FGFR1; HGF
    Rap signaling pathway CALM1; RAC3; BRAF; PRKCA; PIK3R5; RALGDS; PARD6A; KRIT1; PDGFA; PIK3R1
    Chemokine signaling pathway RELA; CXCL1; XCL2; GM13306; ARRB2; CXCL8; ITK; PRKCD; CCR9; PIK3R5
    Endocytosis VPS37C; EPN3; STAMBPB; ZFP652; RABEP1; WIPF2; RHOAD; ARF6B; KITA; STAMBPA
    Axon guidance SEMA7A; PAQR3B; ARPC2; KDR; TRPC4; LRRC4C; PAK2; AP2S1; PLXNA1; EFNB3B
    VEGF signaling pathway MAPK14A; PLA2G4F; HRASB; RAF1A; PIK3R3; PPP3CA; PIK3R1; SPHK1; PRKCB; RAC3
    Focal adhesion CCND1; LAMB4; TNN; COL6A1; ILK; ACTN2; COL6A5; MYL9A; MYLK4; PTK6
    Adherens junction RHOAB; CREBBP; ACTG1; CDC42L; ACTB1; WASL; CDH1; BAIAP2A; CTNNB1; PVRL1B
    Tight junction CLDN20; PARD6B; CLDNA; CLDN8; JAM2A; RAB13; CLDN7; CASKA; CLDN6; MYH6
    T cell receptor signaling pathway NFKBIB; PPP3CC; NFATC1; NFATC2; VAV2; GRB2; MAPK11; MAP3K14; PIK3R3; PIK3CD
    Fc gamma R-mediated phagocytosis WAS; PIK3CA; RAC2; INPP5D; PLA2G4A; CDC42; FCGR1; PLD1; RAF1; ASAP3
    Leukocyte transendothelial migration ACTN2; MLLT4; CLDN1; MYL5; NCF4; ARHGAP5; THY1; MYL2; PLCG2; MAPK11
    Neurotrophin signaling pathway CAMK2A; BRAF; NGFRAP1; AKT2; PSEN1; ZFP110; MAP3K5; MAP3K3; PIK3CD; CAMK2B
    Regulation of actin cytoskeleton PIK3R3A; PXN; PTK2AA; CFL2L; GNA12A; RHOAD; PIK3R3; MYLPFA; MRAS; ABI2
    GnRH signaling pathway CAMK2D1; MAP3K4; PLCB1; HBEGFA; SOS1; RAF1A; CAMK2D; PRKACBA; GNA15.4; MAPK8A
    Non-alcoholic fatty liver disease (NAFLD) Il6ra; PRKAA2; NDUFA4L2; NDUFA12; PIK3R2; NDUFB10; NDUFB6; Casp3; PRKAA1; AKT2
    Bacterial invasion of epithelial cells ELMO2; CLTA; VCL; WASL; SRC; CAV3; CBL; ARPC4; HCLS1; CTTN
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1C2; PLCG1; JAM3; RELA; MAPK13; ATP6V0E1; MAPK12; PAK1; NOD1; ATP6V1B1
    Pathogenic Escherichia coli infection TUBA1B; TLR5; NCL; CDC42; EZR; WAS; ROCK2; ACTG1; YWHAZ; TUBA3C
    Shigellosis ROCK1; PFN2; BTRC; HCLS1; MAPK9; MAPK10; ITGA5; MAPK12; IKBKB; PFN3
    Salmonella infection ROCK1; CXCL1; KLC1B; PLEKHM2; IL8L2; KLC1; IL18; WASL; TLR4; MAPK3
    Pathways in cancer RALGDS; MSH6; NCOA4; GNG12; SMAD3; VEGFA; MET; FGF20; WNT10B; NFKBIA
    Viral carcinogenesis CCND1; RBPJ; RANBP1; CCND2; RBL1; HDAC3; RB1; HIST2H2BE; TBPL2; HIST1H2BH
    Proteoglycans in cancer ITGB5; IGF1R; MRAS; WNT10B; HGF; GAB1; GPC1; VTN; PRKACB; NRAS
    Renal cell carcinoma MET; PAK1; MAP2K1; VHL; TCEB2; EGLN2; RAF1; GAB1; RAPGEF1; PIK3CA
    Pancreatic cancer IKBKG; PIK3R3; TGFB2; IKBKB; TGFBR2; ARHGEF6; CCND1; PIK3R2; RAC1; RALB

    CDC42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42 itself. We selected most functions CDC42 had, and list some proteins which have the same functions with CDC42. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding GEM; DRG1; ARL15A; ARL10; RHEB; ARF5; ARL17B; NPR2; ARFIP2; RAB11BB
    GTP-dependent protein binding PARD6A; PPIAL4A; RAPGEF6; RASGRP4; RAPGEF5; EEA1; GCHFR; GCH1; RAB32; HPS6
    GTPase activity GNAI1; RAB3AA; RAB11BB; RAB3AB; EEF1A1B; TUBG1; GNA13; TUBB1; AGAP2; RHOU
    apolipoprotein A-I receptor binding NR1H2; APOA1; CDC42
    identical protein binding C1S; STXBP1; S100A2; DPP4; FADD; PRPF19; RAD52; SH2B2; TRIM39; SRI
    mitogen-activated protein kinase kinase kinase binding MAPK8IP3; DUSP19; STK38; MAP4K2; MAP2K1; MARVELD3; CDC42; MAPK1; TCF3; MAPK9
    protein binding SERPINE1; STIM1; DYDC1; CDKN2A; MSX2; KCNIP1; PMS2; RBM23; NPBWR2; FBXO33
    protein kinase binding CAMK2N2; CACNB2; GRB7; FBXW5; IBTK; PRC1; CALM1; JAK2; TRAF2; TEX14
    thioesterase binding RAC1; TRAF1; TRAF5; CDC42; CALM3; TRAF3; TRAF2; ADRA2A; ARF6; CALM2
    ubiquitin protein ligase activity HECTD3; PRPF19; UBE2KB; FLJ11011L; HECW1B; RAG2; UBE2KA; RNF115; RNF13; HERC2

    CDC42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42.

    PAK1; WAS

    Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
    Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).

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