cdc42
Share
  • Official Full Name
  • cell division cycle 42
  • Background
  • The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
  • Synonyms
  • CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
Cat.#:CDC42-0934HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-Tagged
+Inquiry
Cat.#:CDC42-0936HTag:GST-pstS1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-pstS1-Tagged
+Inquiry
Cat.#:CDC42-1394HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, T7-tagged
+Inquiry
Cat.#:CDC42-1579HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42 (GTP binding protein, 25kDa), GST-tagged
+Inquiry
Cat.#:CDC42-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, GST-tagged
+Inquiry
Cat.#:CDC42-1024HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42
+Inquiry
Cat.#:CDC42-11008HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST-tagged
+Inquiry
Cat.#:CDC42-1806HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST tagged
+Inquiry
Cat.#:CDC42-2634HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, His-tagged
+Inquiry
Cat.#:CDC42-2635HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, GST-tagged
+Inquiry
Cat.#:CDC42-2636HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(T17N) protein, GST-tagged
+Inquiry
Cat.#:CDC42-2637HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(Q61L) protein, His-tagged
+Inquiry
Cat.#:CDC42-26610THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42
+Inquiry
Cat.#:CDC42-26651THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, T7 -tagged
+Inquiry
Cat.#:CDC42-7033HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST/His-tagged
+Inquiry
Cat.#:CDC42-3139MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDC42 Protein
+Inquiry
Cat.#:CDC42-1277RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDC42 Protein
+Inquiry
Cat.#:CDC42-395CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CDC42 Protein, His-tagged
+Inquiry
Cat.#:CDC42-763RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDC42 Protein, His-tagged
+Inquiry
Cat.#:CDC42-6605CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDC42
+Inquiry
Cat.#:CDC42-10904ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDC42
+Inquiry
Cat.#:CDC42-7655HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDC42 293 Cell Lysate
+Inquiry
Cat.#:Kit-0190Tag:
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric)
+Inquiry
Cat.#:Kit-0191Tag:
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric) II
+Inquiry

Involved Pathway

CDC42 involved in several pathways and played different roles in them. We selected most pathways CDC42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPT; MAP3K4; FGF9; MRAS; MAPKAPK2; FGF22; FGFR3; HSPA1B; FGF11; FGF5
Ras signaling pathway
RAPGEF5; IGF1; IKBKG; GNB4; INS; PLA2G2E; PDGFRB; FGF17; Pdgfa&Pdgfb; GRIN1
Rap signaling pathway
KRAS; RAPGEF1; MRAS; FPR1; BRAF; PDGFA; FGF7; FLT1; RAP1A; Pdgfa&Pdgfb
Chemokine signaling pathway
PIK3CA; RASGRP2; CCL19; CXCL10; PLCB1; XCR1; CRKL; CCL7; CXCL9; CCL15
Endocytosis
FAM21C; HLA-F; SH3GL3B; RAB11FIP1; TGFB1; HSPA2; BF1; GIT2B; TGFB1A; SMAP1
Axon guidance
AP2A2; EFNA1; DLG4; EPHA4A; PPP3R1; PLXNA3; PLXNA1; NRTN; DUSP9; SCN2A
VEGF signaling pathway
CDC42; VEGFAB; PLA2G4A; RAF1B; MAPKAPK2A; MAPK12B; PIK3CG; RAC3; MAPK11; PTK2AA
Focal adhesion
VAV1; THBS1; LAMC3; PAK2A; VTN; MYLPFB; LAMA3; VAV2; MYL2; ELK1
Adherens junction
TCF7; NLK; IGF1RB; PTPRJ; CTNNA2; PVRL4; TCF7L2; FER; ACTG1; INSRA
Tight junction
CLDNC; RHOAD; JAM2; SYMPK; CLDN20; PPP2R2CA; ACTN3B; MYH15; CLDNG; PRKCHA
T cell receptor signaling pathway
CD3G; CD8B; MAPK3; ICOS; MAPK1; IKBKB; MAP2K1; BCL10; CD3E; CD3D; NFKBIB
Fc gamma R-mediated phagocytosis
WASF2; cgr2b; PLA2G4D; PIK3CB; INPP5D; PLCG2; PPAP2C; PIP5K1C; LYN; RAC1
Leukocyte transendothelial migration
PRKCG; F11R; CLDN14; MYL5; PRKCB; MYL9; MYL10; CLDN5; ARHGAP35; PTK2B
Neurotrophin signaling pathway
HRAS; PRDM4; SHC1; MAPK8; RPS6KA1; PSEN2; MAPK13; MAPK12; ABL1; MAP3K3
Regulation of actin cytoskeleton
ARPC5LA; PDGFB; PDGFRA; MYL9A; PIP4K2B; INSRR; PIP5K1C; FGF5; SCINLA; ACTN3
GnRH signaling pathway
RAF1A; PLD2; PLCB3; MAP2K2; MAP2K2B; FSHB; NRAS; PRKACA; SRC; GNRH1
Non-alcoholic fatty liver disease (NAFLD)
UQCRB; COX5A; PIK3R2; TGFB1; COX7B2; NDUFB4; PIK3R3; UQCR10; NDUFB10; CDC42
Bacterial invasion of epithelial cells
PTK2; ACTG1; SEPT11; ELMO3; PIK3CG; CBLB; PIK3R1; ARPC1A; GAB1; PXN
Epithelial cell signaling in Helicobacter pylori infection
MAP3K14; ATP6V1B2; ADAM17; ATP6AP1; RAC1; MAPK8; ATP6V1E1; ATP6V1H; ATP6V1C2; ATP6V0B
Pathogenic Escherichia coli infection
TUBA8; TUBA3C; FYN; TUBB; ROCK1; ITGB1; TUBB2B; TUBAL3; ARHGEF2; ACTB
Shigellosis
ARPC5L; PFN3; ABL1; IKBKB; MAPK1; VCL; CDC42; U2AF1; MAPK3; PFN4
Salmonella infection
MAPK1; MAPK10; ROCK2; RELA; NFKB1; PKN2; ACTB2; ARPC4L; MAPK8B; MAPK13
Pathways in cancer
ROCK1; AGTR1B; FGF16; FGF9; F2R; GRB2; RUNX1; Fzd4; GNAQ; ITGA2
Viral carcinogenesis
GTF2H3; PIK3R1; TBP; CCND2; GTF2H4; REL; SCIN; HIST1H4E; CDK1; HIST1H2BP
Proteoglycans in cancer
PRKACA; TFAP4; WNT8B; PIK3R1; PLCE1; PAK1; CAV3; SLC9A1; PRKCG; PPP1CA
Renal cell carcinoma
RAC1; PAK2; RAF1; MET; EGLN2; VEGFA; TGFA; CDC42; MAP2K2; RAP1A
Pancreatic cancer
MAPK10; RALB; SMAD4; RAC3; PIK3CD; PIK3CG; PIK3R1; TGFBR2; AKT1; PLD1

Protein Function

CDC42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42 itself. We selected most functions CDC42 had, and list some proteins which have the same functions with CDC42. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein RAC3; RAB30; RAB23; RAB1; HRAS; RAB3B; RAP2C; EHD3; PCK2; RAB19
Function GTP-dependent protein binding
Related Protein PPIAL4A; CDC42; RAB38; AP1G1; GCHFR; RAPGEF5; MRAS; RAB32; HPS6; ARFIP2
Function GTPase activity
Related Protein RHOU; RAB1BA; GBP1; EEF2A.2; GSPT1L; GTPBP10; MX2; TUBB1; RAB1A; GNAO1B
Function apolipoprotein A-I receptor binding
Related Protein CDC42; APOA1; NR1H2
Function identical protein binding
Related Protein DAPK3; C1QL4; PPP5C; PARP1; APAF1; RUNX1T1; RIPK3; LCP1; MIEF1; ZNF3
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MAPK9; MARVELD3; DUSP19; MAPK1; TRAF6; MAP2K1; MAP3K11; CDC37; STK38; PPEF2
Function protein binding
Related Protein SCARA5; ATP2B4; ASGR1; PDLIM2; PRKCQ; WBP2NL; ERCC2; RPP30; CDC42EP5; IFIT1
Function protein kinase binding
Related Protein PPP1R12A; IBTK; RPS3; MAPK6; CHEK2; PAK2; SLC12A5; YWHAZ; ADCY6; FAM83B
Function thioesterase binding
Related Protein ARF6; RAC1; CALM2; ADRA2A; CDC42; TRAF3; TRAF5; TRAF1; TRAF2; CALM
Function ubiquitin protein ligase activity
Related Protein UBE3C; RNF220; HECW2; PARK2; ZNRF2; UBE2S; RNF126; RLIM; AKTIP; ANAPC11

Interacting Protein

CDC42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42.
PAK1; WAS

CDC42 Related Articles

Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).