cdc42
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  • Official Full Name
  • cell division cycle 42
  • Background
  • The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
  • Synonyms
  • CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
Cat.#:CDC42-0934HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-Tagged
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Cat.#:CDC42-0936HTag:GST-pstS1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-pstS1-Tagged
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Cat.#:CDC42-1394HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, T7-tagged
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Cat.#:CDC42-1579HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42 (GTP binding protein, 25kDa), GST-tagged
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Cat.#:CDC42-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, GST-tagged
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Cat.#:CDC42-1024HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42
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Cat.#:CDC42-11008HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST-tagged
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Cat.#:CDC42-1806HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST tagged
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Cat.#:CDC42-2634HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, His-tagged
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Cat.#:CDC42-2635HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, GST-tagged
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Cat.#:CDC42-2636HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(T17N) protein, GST-tagged
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Cat.#:CDC42-2637HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(Q61L) protein, His-tagged
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Cat.#:CDC42-26610THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42
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Cat.#:CDC42-26651THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, T7 -tagged
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Cat.#:CDC42-7033HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST/His-tagged
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Cat.#:CDC42-3139MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDC42 Protein
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Cat.#:CDC42-1277RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDC42 Protein
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Cat.#:CDC42-395CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CDC42 Protein, His-tagged
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Cat.#:CDC42-763RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDC42 Protein, His-tagged
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Cat.#:CDC42-6605CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDC42
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Cat.#:CDC42-10904ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDC42
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Cat.#:CDC42-7655HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDC42 293 Cell Lysate
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Cat.#:Kit-0190Tag:
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric)
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Cat.#:Kit-0191Tag:
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric) II
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Involved Pathway

CDC42 involved in several pathways and played different roles in them. We selected most pathways CDC42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TRAF6; FGFR1A; IL1R1; MEF2CB; RAF1; FGF18; MAP3K7; MAPK1; RAC1B; MAPK14A
Ras signaling pathway
AKT2; PAK2; INS2; VEGFB; MAP2K2; PIK3CA; MAPK3; ANGPT2; KIT; FIGF
Rap signaling pathway
ANGPT1; KLK1B4; PFN2; FGF20; PGF; VEGFC; ACTG1; VASP; ANGPT2; FGF10
Chemokine signaling pathway
GRK5; STAT1; CX3CL1; CCL16; ARRB2; GNAI3; GNG10; PIK3CB; GNGT1; CXCL6
Endocytosis
EHD3; PIP5K1C; RAB10; SMAP1; TGFBR2; CLINT1A; HSPA2; ARFGAP1; KITB; WIPF1
Axon guidance
MYL9; ABLIM2; EFNA4; FGF20A; EGF; NFATC2; Ntng2; SRGAP3; KCNQ2; SLIT3
VEGF signaling pathway
CDC42L2; PTK2AA; PIK3R1; SHC2; PRKCA; PRKCBA; RAF1; RAF1B; MAPK12; PRKCG
Focal adhesion
SOS1; PPP1R12A; LAMA1; PRKCBA; LAMC2; PDPK1B; SRMS; DIAPH1; MYLPFB; LAMC1
Adherens junction
FYNB; WASF2; BAIAP2A; ACTB; PTPRFB; WAS; FYNA; BAIAP2; PTPRJ; EGFR
Tight junction
EPB41L3B; SRC; CLDN16; RHOA; GNAI2B; MYLPFB; RHOAC; MYH1B; CDC42; GNAI2A
T cell receptor signaling pathway
PTPRC; CD28; GRB2; CD8B; PPP3CA; PAK7; MAPK13; MAP2K2; IKBKG; LCP2
Fc gamma R-mediated phagocytosis
MYO10; SPHK1; PIK3R5; PIP5K1C; CFL2; PIK3CA; ARPC1A; NCF1; PPAP2C; RPS6KB2
Leukocyte transendothelial migration
RHOH; THY1; MYL10; CLDN23; GNAI3; RHOA; CLDN20; VAV2; ITGA4; CLDN18
Neurotrophin signaling pathway
AKT2; MAPK10; PIK3R1; RAF1; SHC1; PRDM4; TP73; MAPK11; MAPK7; PLCG2
Regulation of actin cytoskeleton
FGF1B; PFN2L; Itgam&Itgb2; ARHGEF6; MYLPFB; ABI2; CYFIP2; FGF12; ITGB3B; ARHGEF7A
GnRH signaling pathway
GRB2B; PRKCBB; CALM2B; CAMK2G1; CACNA1D; ATF4; SRC; PLCB2; PLA2G4A; MAP2K4A
Non-alcoholic fatty liver disease (NAFLD)
NDUFB5; COX6B2; LEP; NDUFS8; CASP8; COX4I2; INS; CEBPA; NDUFC2-KCTD14; COX7A2L
Bacterial invasion of epithelial cells
WASF2; DNM3; ARPC4; DOCK1; SEPT9; ARPC5; CLTB; CDH1; PTK2; ARPC2
Epithelial cell signaling in Helicobacter pylori infection
CXCL1; ATP6V1E2; RELA; MAP2K4; ATP6V0C; ATP6V1G3; CXCR1; IL-8; LYN; ATP6V0A4
Pathogenic Escherichia coli infection
TUBB2B; NCL; TUBA3E; TUBA1B; TUBA3C; FYN; ROCK2; CDH1; CTTN; TUBA4A
Shigellosis
MAD2L2; PFN3; CDC42; NFKB1; MAPK1; NFKBIB; ARPC5L; SRC; MAPK3; RHOG
Salmonella infection
RHOG; CDC42; DYNC1I1; PKN2; DYNC1LI1; KLC1B; PFN2L; RHOGC; MAPK8; ARPC5LB
Pathways in cancer
DAPK3; TGFB1; TRAF5; HRAS; PLCB1; CYCS; CASP8; RALB; MMP9; RAC1
Viral carcinogenesis
YWHAE; RBPJL; RBL2; TP53; CCNA2; VAC14; HIST1H4F; GTF2A1; MAPKAPK2; RBPJ
Proteoglycans in cancer
WNT3A; PPP1CA; FZD1; DDX5; HSPB2; MAPK13; ACTG1; TNF; CAMK2A; PIK3CD
Renal cell carcinoma
PAK3; TGFB3; BRAF; PAK6; RAP1B; RAC1; PIK3CB; TGFA; TCEB2; PAK1
Pancreatic cancer
TP53; PIK3CA; BRCA2; ARHGEF6; RALB; RALGDS; MAPK10; RAF1; TGFA; PLD1

Protein Function

CDC42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42 itself. We selected most functions CDC42 had, and list some proteins which have the same functions with CDC42. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein EFTUD2; HRAS; RAB40C; RAC1B; RRAD; RAB3C; GMPPAB; SEPT1; RAB4A; RHOJ
Function GTP-dependent protein binding
Related Protein EEA1; RAB38; GCH1; RAB32; RAB5B; GCHFR; RASGRP4; RAPGEF5; AP3B1; RAPGEF6
Function GTPase activity
Related Protein DNM3A; RABL2; RAB3AA; RAB44; RRAS; GNG10; RAP1GAP; RAB40AL; GNAO1; EFTUD1
Function apolipoprotein A-I receptor binding
Related Protein APOA1; NR1H2; CDC42
Function identical protein binding
Related Protein ATL1; TFRC; CLDN4; SERPINA1A; S100A4; SH2B2; RYR2; CLPP; PRC1; UBQLN4
Function mitogen-activated protein kinase kinase kinase binding
Related Protein PPEF2; CDC37; STK38; DUSP19; MARVELD3; MAP4K2; MAPK8IP3; MAPK9; TRAF6; TRAF2
Function protein binding
Related Protein ZBTB9; MRPL23; TTR; PMS2; PTPN12; RAB4A; GPRIN2; COG2; SHOX; BIK
Function protein kinase binding
Related Protein LIPE; ATF2; MAP3K5; PTPN6; NEFH; ARHGEF7; PTPRJ; FAM83B; KCNQ3; FBXW5
Function thioesterase binding
Related Protein ADRA2A; CDC42; TRAF2; CALM2; CALM; TRAF5; TRAF1; TRAF4; RAC1; ARF6
Function ubiquitin protein ligase activity
Related Protein ZNRF2; UBE2Z; TRAIP; RAG1; RAG2; UBE3B; UBE2B; CBLC; RAD18; RNF149

Interacting Protein

CDC42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42.
PAK1; WAS

CDC42 Related Articles

Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).