cdc42
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  • Official Full Name
  • cell division cycle 42
  • Background
  • The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
  • Synonyms
  • CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
Cat.#:CDC42-0934HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-Tagged
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Cat.#:CDC42-0936HTag:GST-pstS1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-pstS1-Tagged
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Cat.#:CDC42-1394HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, T7-tagged
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Cat.#:CDC42-1579HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42 (GTP binding protein, 25kDa), GST-tagged
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Cat.#:CDC42-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, GST-tagged
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Cat.#:CDC42-1024HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42
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Cat.#:CDC42-11008HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST-tagged
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Cat.#:CDC42-1806HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST tagged
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Cat.#:CDC42-2634HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, His-tagged
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Cat.#:CDC42-2635HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, GST-tagged
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Cat.#:CDC42-2636HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(T17N) protein, GST-tagged
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Cat.#:CDC42-2637HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(Q61L) protein, His-tagged
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Cat.#:CDC42-26610THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42
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Cat.#:CDC42-26651THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, T7 -tagged
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Cat.#:CDC42-7033HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST/His-tagged
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Cat.#:CDC42-3139MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDC42 Protein
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Cat.#:CDC42-1277RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDC42 Protein
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Cat.#:CDC42-395CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CDC42 Protein, His-tagged
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Cat.#:CDC42-763RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDC42 Protein, His-tagged
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Cat.#:CDC42-6605CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDC42
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Cat.#:CDC42-10904ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDC42
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Cat.#:CDC42-7655HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CDC42 293 Cell Lysate
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Cat.#:Kit-0190Tag:
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric)
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Cat.#:Kit-0191Tag:
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric) II
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Involved Pathway

CDC42 involved in several pathways and played different roles in them. We selected most pathways CDC42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PPM1AA; MRAS; MAP4K3; GADD45G; MAP3K11; RAF1; BRAF; FGF13A; FGF1; IL1A
Ras signaling pathway
RAB5C; PLCE1; BAD; MAP2K2; IGF1R; RAC1; FOXO4; CALM4; INS1; RASAL2
Rap signaling pathway
IGF1; KIT; VEGFC; FGFR1; MRAS; ARAP3; MAP2K3; MAPK11; VAV2; TEK
Chemokine signaling pathway
CXCR1; CXCR5; CCL3L3; AMCF-II; PRKACG; NCF1; RLN1; CCL24; CCL2; CCL27
Endocytosis
RAB22A; RAB11FIP4B; PARD6A; RNF103-CHMP3; PSD2; PARD6B; AP2M1B; RAB5AA; EHD2; HLA-A
Axon guidance
CNTN1; ITGB3A; SCN3B; PPP3CC; LIMK1; RHOC; PLXNA3; EPHA4A; EZRA; EFNA1
VEGF signaling pathway
RAF1B; PPP3R2; KRAS; PPP3CC; PLA2G4F; AKT1; MAPK11; RAF1; AKT3A; MAPK12A
Focal adhesion
PIK3R1; ACTB2; SRMS; COL2A1A; MAPK1; MYL12.2; GSK3B; SHC2; RHOAB; ITGA7
Adherens junction
SRC; FYNB; ACTN2B; CSNK2B; RAC3; WASLB; MET; RAC1; IGF1RB; NLK2
Tight junction
MYH15; CASKA; MRAS; MYL9A; RAB3B; YBX3; MYH11; CLDN7; MYL2B; VMHC
T cell receptor signaling pathway
PAK6; PLCG1; VAV2; CD247; ICOS; PAK2; MUC1; DEF6A; ZAP70; TEC
Fc gamma R-mediated phagocytosis
WASF1; PIP5K1C; GAB2; BIN1; FCGR2B; VASP; AKT2; SPHK1; RPS6KB1; PLCG2
Leukocyte transendothelial migration
CDC42; MYL2; PIK3CA; ROCK1; CLDN18; ITGB2L; MMP2; PIK3R1; ITGAM; MMP9
Neurotrophin signaling pathway
CALM1; CAMK2A; PTPN11; SH2B3; MAPK7; IKBKB; RAF1; IRAK1; CAMK2B; CDC42
Regulation of actin cytoskeleton
PAK7; PIP5K1B; GNA13A; BRAF; Itgam&Itgb2; FGF14; SLC9A1; CFL2L; VAV1; PIP5K1AA
GnRH signaling pathway
MMP2; RAF1; GNRHR4; MAP2K7; MAPK3; PRKCB; GNAQ; PLA2G4F; MAP3K4; CAMK2B
Non-alcoholic fatty liver disease (NAFLD)
CASP7; NDUFB10; NDUFB3; NDUFC2; COX7A2; COX7B; UQCRB; CASP8; UQCRC1; IL6R
Bacterial invasion of epithelial cells
RHOG; BCAR1; DNM1; CAV2; CDH1; SHC1; SEPT9; PIK3R5; ELMO1; PIK3CA
Epithelial cell signaling in Helicobacter pylori infection
MET; ATP6V1B2; ATP6V1G1; ATP6V1H; PLCG2; ATP6V1E1; CCL5; TJP1; MAPK10; NOD1
Pathogenic Escherichia coli infection
ACTG1; TUBB2A; YWHAZ; TUBA1A; ROCK1; TLR4; TUBA8; TUBB7P; PRKCA; TUBA3E
Shigellosis
MAPK9; NFKBIA; ARPC5L; ABL1; ITGB1; CDC42; CD44; PFN1; DIAPH1; ATG5
Salmonella infection
MYH10; ARPC5LA; TLR4BB; FOS; WASF1; MAPK8; RAC1B; MAPK9; IFNG; DYNC1LI1
Pathways in cancer
LAMB4; AHA-1; HHIP; MAP2K2; MITF; KIT; PTGER2; PRKCB; VEGFA; FGF16
Viral carcinogenesis
CDC42; PRKACG; STAT3; HIST1H2BK; CCND3; HIST3H2BB-PS; PIK3R5; UBR4; RBPJ; PSMC1
Proteoglycans in cancer
PRKCA; PAK1; PRKCB; MAPK13; PRKACB; FASLG; PIK3R3; WNT16; CCND1; RPS6KB2
Renal cell carcinoma
FH; EPAS1; MAP2K1; PIK3R3; MAP2K2; TGFB2; AKT1; MAPK1; RAP1A; TCEB2
Pancreatic cancer
TRP53; PIK3R5; IKBKB; PIK3R1; SMAD2; STAT1; VEGFA; TGFB1; SMAD3; PLD1

Protein Function

CDC42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42 itself. We selected most functions CDC42 had, and list some proteins which have the same functions with CDC42. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein RAB1A; RHOGC; RHOBTB1; GTPBP5; RAB26; TUBB2A; RHOGB; EHD1A; RAP1AB; GNAT3
Function GTP-dependent protein binding
Related Protein EEA1; ARFIP2; RAB5B; AP1G1; PPIAL4A; RAB32; RASGRP4; RAPGEF5; GCH1; PARD6A
Function GTPase activity
Related Protein GNAO1A; RAB8B; GTPBP1; TUBB4B; GNB1; RAB13; MX1; ATL1; GNAT1; RAB25
Function apolipoprotein A-I receptor binding
Related Protein CDC42; APOA1; NR1H2
Function identical protein binding
Related Protein CTSC; TRAF2; BLOC1S6; CLDN2; NOD1; RB1; DPY30; IGF2R; STIM1; SMAD4
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MAPK8IP3; MAPK1; CDC42; MARVELD3; TCF3; STK38; MAP2K1; CDC37; MAP3K11; MAP4K2
Function protein binding
Related Protein KLK6; ZKSCAN5; MAGEF1; NHLH2; PKP1; HTR3C; GPR158; SMCR7; CDKN2A; MAGEE1
Function protein kinase binding
Related Protein TELO2; CD36; SPDYE2; PPP1CC; RAB8A; DNAJC3; PPP1CB; GDF3; GSK3B; BCL10
Function thioesterase binding
Related Protein ARF6; CDC42; CALM1; CALM; RAC1; TRAF3; TRAF2; TRAF1; TRAF5; HAUS7
Function ubiquitin protein ligase activity
Related Protein RABGEF1; TRIM11; UBE2Z; UBE2W; HUWE1; CDC42; HECTD1; LRSAM1; MYLIP; RNF126

Interacting Protein

CDC42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42.
PAK1; WAS

CDC42 Related Articles

Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).