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CDC42

  • Official Full Name

    cell division cycle 42

  • Overview

    The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
  • Synonyms

    CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • GST|His
  • GST|pstS1
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDC42-2634H Active Recombinant Human CDC42 protein, His-tagged E.coli His
Human CDC42-2635H Active Recombinant Human CDC42 protein, GST-tagged E.coli GST
Human CDC42-2636H Active Recombinant Human CDC42(T17N) protein, GST-tagged E.coli GST
Human CDC42-0934H Recombinant Human CDC42 Protein, GST-Tagged Wheat Germ GST
Human CDC42-26610TH Recombinant Human CDC42 E.coli N/A
Human CDC42-1806H Recombinant Human CDC42 protein(Met1-Cys188), GST-tagged E. coli N-GST Met1-Cys188
Human CDC42-7033H Recombinant Human CDC42, GST/His-tagged E.coli GST/His Full length
Human CDC42-0936H Recombinant Human CDC42 Protein, GST-pstS1-Tagged Wheat Germ GST/pstS1
Human CDC42-26651TH Recombinant Human CDC42, T7 -tagged E.coli T7
Human CDC42-11008H Recombinant Human CDC42, GST-tagged E.coli GST 1-186a.a.
Human CDC42-1024H Recombinant Human Cell Division Cycle 42 E.coli N/A
Human CDC42-1394H Recombinant Human Cell Division Cycle 42, T7-tagged E.coli T7
Human CDC42-1023H Recombinant Human Cell Division Cycle 42, GST-tagged E.coli GST
Human CDC42-1579H Recombinant Human Cell Division Cycle 42 (GTP binding protein, 25kDa), GST-tagged E.coli GST
Human CDC42-2637H Recombinant Human CDC42(Q61L) protein, His-tagged E.coli His
Human CDC42-7655HCL Recombinant Human CDC42 293 Cell Lysate HEK293 N/A
Human CDC42-1712H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDC42-4183H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDC42-0974H Recombinant Human CDC42 Protein (Met1-Cys188), N-His tagged E.coli N-His Met1-Cys188
Human CDC42-6646H Recombinant Human CDC42 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDC42-3076HF Recombinant Full Length Human CDC42 Protein, GST-tagged In Vitro Cell Free System GST 191 amino acids
Human CDC42-3101HF Recombinant Full Length Human CDC42 Protein, GST-tagged In Vitro Cell Free System GST 191 amino acids
Mouse CDC42-3139M Recombinant Mouse CDC42 Protein Mammalian Cell His
Mouse CDC42-1484M Recombinant Mouse CDC42 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDC42-1484M-B Recombinant Mouse CDC42 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cdc42-856M Recombinant Mouse Cdc42 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CDC42-1277R Recombinant Rat CDC42 Protein Mammalian Cell His
Rat CDC42-935R-B Recombinant Rat CDC42 Protein Pre-coupled Magnetic Beads HEK293
Rat CDC42-935R Recombinant Rat CDC42 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CDC42-395C Recombinant Cynomolgus CDC42 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CDC42-143C Recombinant Cynomolgus Monkey CDC42 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CDC42-143C-B Recombinant Cynomolgus Monkey CDC42 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDC42-763R Recombinant Rhesus monkey CDC42 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDC42-589R-B Recombinant Rhesus Macaque CDC42 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDC42-589R Recombinant Rhesus Macaque CDC42 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CDC42-10904Z Recombinant Zebrafish CDC42 Mammalian Cell His
Chicken CDC42-6605C Recombinant Chicken CDC42 Mammalian Cell His
Kit-0190 Cdc42 G-LISA Activation Assay Kit (Colorimetric) N/A
Kit-0191 Cdc42 G-LISA Activation Assay Kit (Colorimetric) II N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDC42 Related Articles
  • CDC42 Related Research Area
  • CDC42 Related Signal Pathway

CDC42 involved in several pathways and played different roles in them. We selected most pathways CDC42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayGADD45AB;NR4A1;ARRB2;MAPK12A;GNG12;MAPK8IP3;HSPA1L;HSPA6;PAK1
Ras signaling pathwayKLK1B4;MAP2K1;RAF1;PLA2G1B;PLA2G3;GAB2;GNG3;GNG11;MRAS
Rap signaling pathwayMAP2K6;DOCK4;GNAS;MAP2K3;GNAI1;FGF21;KIT;ITGB1;RAP1B
Chemokine signaling pathwayCXCL9;HRAS;PIK3CG;CXCL5;KRAS;CXCL6;GNG2;IL-8;PIK3R3
EndocytosisSMAP2;CHMP4B;ARAP2;H2-Q10;SNX32;SMAD3;ADRBK2;EPN3;PSD4
Axon guidanceEPHB3A;CAP2;RAC1;COL6A2;SHB;CFL2;ARPC2;DPYSL2B;SEMA4A
VEGF signaling pathwayPRKCBB;MAPK3;RAC3B;NRAS;MAPK12A;PXN;PIK3R3B;AKT2L;KRAS
Focal adhesionPARVAA;FLNC;LAMB4;LAMB1;PTK2AA;ITGB7;VAV3;IGF1RA;CDC42L2
Adherens junctionACTN3B;PVRL1;RHOAD;WAS;NLK1;NLK;TJP1;VCLA;WASF2
Tight junctionCLDN17;LLGL2;CLDN22;CLDN9;MPP5;PRKCBB;SMYHC1;CLDN7B;CRB3
T cell receptor signaling pathwayLAT;MAP3K14;PAK3;TNF;RHOA;CD8A;FOS;PPP3R1;CD4
Fc gamma R-mediated phagocytosiscgr2b;PLCG2;ARF6;ARPC1A;MAP2K1;PIK3R3;SPHK2;PIK3CD;NCF1
Leukocyte transendothelial migrationACTN1;PLCG1;CLDN20;MYL10;CLDN23;ITGB2;RAP1B;CLDN22;CTNNA3
Neurotrophin signaling pathwayNTRK2;ATF4;HRAS;SHC1;PIK3CB;RPS6KA2;MAPK8;ARHGDIA;TRAF6
Regulation of actin cytoskeletonABI2A;PIK3CA;FGD;MAP2K1;PIK3R5;PPP1R12A;ACTG1;RDX;MSN
GnRH signaling pathwayCACNA1SB;MMP14B;MAP2K2;MAPK12B;HRAS;MAPK8A;SOS1;CALM1B;CAMK2A
Non-alcoholic fatty liver disease (NAFLD)SDHA;COX7B;NDUFV3;PKLR;INS1;NDUFB6;PRKAG2;PIK3R3;SDHD
Bacterial invasion of epithelial cellsARPC1B;FN1;CAV2;MET;ARPC2;PIK3CB;SEPT11;SHC1;ARPC4
Epithelial cell signaling in Helicobacter pylori infectionSRC;RAC1;PLCG1;ADAM17;GIT1;F11R;IKBKB;NFKBIA;TJP1
Pathogenic Escherichia coli infectionTUBA1C;WASL;ACTG1;LY96;PRKCA;TUBA1B;TUBA4A;NCK2;ABL1
ShigellosisMAPK12;ATG5;FBXW11;NFKBIA;WASL;CD44;ROCK2;PFN2;MAPK8
Salmonella infectionCASPA;CXCL1;CXCL3;NOS2;MAPK12;CCL3L1;MAPK9;TLR5;RELA
Pathways in cancerSTAT5B;Fzd4;PPARD;FGF19;IKBKG;ARAF;GNAS;Pdgfa&Pdgfb;FN1
Viral carcinogenesisMDM2;LYN;GTF2H2;HLA-B;TRAF2;HIST1H2BN;RAC1;HIST1H2BI;CASP8
Proteoglycans in cancerVTN;MDM2;LUM;THBS1;ELK1;PXN;FASLG;PTK2;FLNC
Renal cell carcinomaHIF1A;EGLN2;PIK3R1;RAP1A;FLCN;PIK3R5;PAK6;PIK3CD;PIK3CG
Pancreatic cancerTGFBR2;MAP2K1;RAF1;TGFA;MAPK10;TGFBR1;SMAD3;RALB;RELA

CDC42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42 itself. We selected most functions CDC42 had, and list some proteins which have the same functions with CDC42. You can find most of the proteins on our site.

Function Related Protein
GTP bindingGNAI2;ANXA6;TUBB4A;ERCC3;RALAA;TUBA1L2;GNAI3;SEPT5;IRGM
GTP-dependent protein bindingRAB38;RAB32;GCHFR;HPS6;EEA1;RAPGEF5;MRAS;AP3B1;RASGRP4
GTPase activityRALBB;GNAZ;MTIF2;HRAS;RAB1BA;LGALS6;ATL3;RAB25B;GNAT1
apolipoprotein A-I receptor bindingNR1H2;CDC42;APOA1
identical protein bindingCCL4;CLDN11;BNIP3L;TNF;NISCH;CCDC91;HCN2;SNCAIP;ST13
mitogen-activated protein kinase kinase kinase bindingCDC37;MAP4K2;TRAF2;CDC42;STK38;MAPK1;TRAF6;MAP2K1;MAP3K11
protein bindingLRP12;ECHS1;HSPB11;BRD8;RAD51B;NDEL1;CD74;RAPGEF3;HSPB9
protein kinase bindingCALM2;CAV2;CRY1;ATF2;CDK5;SMAD1;ADAM10;GHR;SPDYA
thioesterase bindingCALM2;HAUS7;TRAF3;CDC42;RAC1;ADRA2A;TRAF1;TRAF6;TRAF4
ubiquitin protein ligase activityTRIM37;RNF6;RNF146;UBE2C;TRIP12;RNF13;UBE2A;RNF121;RNF165

CDC42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42.

PAK1; WAS

Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does CDC42 regulate cytoskeletal reorganization and cell morphology changes? 02/11/2022

CDC42 controls cytoskeletal dynamics, leading to changes in cell shape and movement.

What is the impact of CDC42 on neuronal development and synaptic plasticity? 06/13/2019

CDC42 is important in neuronal development and plays a role in forming and remodeling synaptic connections.

How do alterations in CDC42 expression or activity affect aging and age-related diseases? 12/08/2018

Changes in CDC42 activity can impact aging processes and contribute to the development of age-related diseases.

How does CDC42 contribute to cancer cell migration, invasion, and metastasis? 10/30/2018

CDC42 facilitates cancer progression by enhancing cell migration, invasion, and metastatic potential.

How does CDC42 influence wound healing and tissue regeneration? 08/06/2018

CDC42 aids in wound healing and regeneration by guiding cell migration and tissue restructuring.

What role does CDC42 play in the process of cell division and cell cycle regulation? 07/14/2018

CDC42 is crucial for cell division and cycle progression, coordinating cellular events for proper division.

What are the mechanisms by which CDC42 modulates immune cell trafficking and activation? 07/02/2018

CDC42 regulates immune cell movement and activation, essential for immune response and surveillance.

Customer Reviews (3)

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Reviews
03/28/2021

    Reliable protein crystallography, essential for structural studies.

    09/08/2019

      Exceptional protein engineering services, meets our lab's needs.

      05/01/2018

        Efficient peptide synthesis, crucial for our peptide research.

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