cdc42
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  • Official Full Name
  • cell division cycle 42
  • Background
  • The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
  • Synonyms
  • CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD));
Cat.#:CDC42-0934HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-Tagged
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Cat.#:CDC42-0936HTag:GST|pstS1
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC42 Protein, GST-pstS1-Tagged
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Cat.#:CDC42-1394HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, T7-tagged
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Cat.#:CDC42-1579HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42 (GTP binding protein, 25kDa), GST-tagged
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Cat.#:CDC42-1023HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42, GST-tagged
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Cat.#:CDC42-1024HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cell Division Cycle 42
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Cat.#:CDC42-11008HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST-tagged
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Cat.#:CDC42-1806HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST tagged
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Cat.#:CDC42-2634HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, His-tagged
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Cat.#:CDC42-2635HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42 protein, GST-tagged
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Cat.#:CDC42-2636HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(T17N) protein, GST-tagged
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Cat.#:CDC42-2637HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42(Q61L) protein, His-tagged
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Cat.#:CDC42-26610THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42
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Cat.#:CDC42-26651THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, T7 -tagged
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Cat.#:CDC42-7033HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC42, GST/His-tagged
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Cat.#:CDC42-3139MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDC42 Protein
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Cat.#:CDC42-1277RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDC42 Protein
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Cat.#:CDC42-395CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CDC42 Protein, His-tagged
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Cat.#:CDC42-763RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDC42 Protein, His-tagged
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Cat.#:CDC42-6605CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDC42
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Cat.#:CDC42-10904ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDC42
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Cat.#:CDC42-7655HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CDC42 293 Cell Lysate
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Cat.#:Kit-0190Tag:N/A
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric)
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Cat.#:Kit-0191Tag:N/A
Source (Host):Species:
Product nameCdc42 G-LISA Activation Assay Kit (Colorimetric) II
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Involved Pathway

CDC42 involved in several pathways and played different roles in them. We selected most pathways CDC42 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC42 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK8B; NFATC3; HSPB1; CACNA2D3; FGFR1; MKNK1; RPS6KA3B; PRKACAA; FGF1; NTF3
Ras signaling pathway
RAB5C; PLD2; GRIN2B; SHOC2; RAC1; LAT; RASGRP3; ETS2; FLT1; Fgf15
Rap signaling pathway
LPAR5; KRIT1; MAPK11; GRIN1; PARD6B; KITLG; FGF22; PLCE1; PRKCG; FGF8
Chemokine signaling pathway
CXCL9; GNB1; CCL21B; GNG5; DOCK2; CCL2; RAP1B; GSK3B; JAK2; GNG12
Endocytosis
IQSEC1; HSPA1B; RET; CYTH1; VPS26A; ERBB4A; STAMBPB; ARRB2B; ITCH; VPS37D
Axon guidance
SPTB; SEMA3D; NCK1; RHOA; FRS2; SDCBP; DNM1; EPHB6; EFNB1; ITGB1B.1
VEGF signaling pathway
PPP3CCB; CDC42; PTK2; PRKCA; MAPK12; NRAS; HSPB1; PTGS2; MAP2K2A; MAPKAPK2
Focal adhesion
PAK6B; MAPK10; THBS4A; COL4A2; MYL5; PXNA; RAP1AA; COL5A2; HRASA; VEGFB
Adherens junction
WASF3; WASF2; ACTG1; TCF7L1A; CREBBP; WASL; INSRA; SNAI1; CDC42L; SMAD3
Tight junction
CLDNF; PARD6A; CLDNE; PARD6GA; OCLNA; MPDZ; CLDN9; CLDN5; OCLNB; MPP5A
T cell receptor signaling pathway
PAK1; GSK3B; NCK1; CD8B1; LCK; PIK3CB; CD40LG; MAP3K14; MAPK12; CD3D
Fc gamma R-mediated phagocytosis
PRKCA; PIK3CA; NCF1; RAC1; ARPC5L; MAPK3; GSN; CFL1; PLD2; INPP5D
Leukocyte transendothelial migration
F11R; ACTN4; PIK3CD; ACTN3; Itgam&Itgb2; MYL9; GNAI3; EZR; ACTN2; CDC42
Neurotrophin signaling pathway
MAPK11; MAPK1; PTPN11; MAP2K1; FOXO3; CAMK2A; TRAF6; Fasl; PLCG2; CALM2
Regulation of actin cytoskeleton
FGFR2; PTK2; PXN; ACTN2B; ITGA3; EZRB; ARAF; PDGFB; FGF5; PIP4K2B
GnRH signaling pathway
CALM3B; GRB2; CGNRH-R; CDC42; PTK2B; PRKACAA; CAMK2B1; PRKCDA; CACNA1D; PLCB2
Non-alcoholic fatty liver disease (NAFLD)
INS; UQCRC2; NDUFA4L2; GSK3B; PIK3R2; UQCRFS1; COX7A2; GSK3A; NDUFB3; NDUFS8
Bacterial invasion of epithelial cells
FN1; SHC2; ARPC5; CTNNA3; PIK3CG; GAB1; ELMO2; SHC4; CRK; ACTB
Epithelial cell signaling in Helicobacter pylori infection
SRC; ATP6AP1; MAPK11; ATP6V0A2; NOD1; MAPK9; ATP6V1B2; ATP6V0D2; PAK1; IKBKG
Pathogenic Escherichia coli infection
ROCK1; RHOA; TUBB2A; FYN; PRKCA; TLR4; TUBA3C; YWHAZ; OCLN; NCK2
Shigellosis
UBE2D2; ABL1; MAPK11; NFKBIB; ITGA5; NFKBIA; ITGB1; MAPK13; CDC42; WASL
Salmonella infection
ACTB2; RHOGC; RELA; MAPK11; TJP1; TLR5B; IL8L1; CCL3; MAPK12A; WASB
Pathways in cancer
COL4A1; PIK3R1; Adcy4; RASSF1; PRKACB; HSP90B1; TCEB1; ROCK1; WNT7A; ZBTB16
Viral carcinogenesis
HDAC3; VAC14; UBE3A; STAT5B; PIK3CA; HDAC1; HIST2H2BE; HLA-B; PKM2; PIK3CG
Proteoglycans in cancer
ACTG1; PTPN11; GPC1; RPS6KB2; HSPG2; TRP53; RPS6KB1; RRAS2; CAMK2A; CAV2
Renal cell carcinoma
MAP2K2; PIK3CB; PAK6; TGFB2; PIK3R2; PAK3; TCEB1; PTPN11; ETS1; CUL2
Pancreatic cancer
PIK3R3; TGFB2; BCL2L1; MAPK10; SMAD3; KRAS; RAC1; RAD51; PIK3R2; TGFBR2

Protein Function

CDC42 has several biochemical functions, for example, GTP binding, GTP-dependent protein binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC42 itself. We selected most functions CDC42 had, and list some proteins which have the same functions with CDC42. You can find most of the proteins on our site.
Function
Related Protein
Function GTP binding
Related Protein RAB11AL; ARL2; GNL2; GNA15; DNM2B; ARF6B; DNAJC27; ARL9; GNAV1; RERGLA
Function GTP-dependent protein binding
Related Protein ARFIP2; RAB5B; RAB38; CDC42; GCH1; PARD6A; EEA1; RAPGEF6; PPIAL4A; RAB32
Function GTPase activity
Related Protein TUBA8; RRAGA; DNM1L; ARL3; RAB40C; EEF1A1A; EIF5B; GNAI3; RAB25B; HRAS
Function apolipoprotein A-I receptor binding
Related Protein CDC42; NR1H2; APOA1
Function identical protein binding
Related Protein TFRC; MSANTD3; TRAF2; SNX16; PRDX1; JMJD6; RB1; PDCD6; L1CAM; GSTM3
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MARVELD3; TRAF2; MAPK9; MAPK1; CDC42; PPEF2; TRAF6; MAPK8IP3; MAP4K2; STK38
Function protein binding
Related Protein TRPC3; C6orf226; PTPN18; NFIX; GP1BB; CIB2; TMED1; ERCC6L; MTX2; HIST1H3H
Function protein kinase binding
Related Protein KIF20A; RICTOR; EEF2; PTK2; AP1B1; ACSL3; LLGL1; PTPN1; CDC25A; SREBF1
Function thioesterase binding
Related Protein CALM2; CALM3; RAC1; CALM1; TRAF5; ADRA2A; ARF6; TRAF3; TRAF2; TRAF6
Function ubiquitin protein ligase activity
Related Protein UBE2G1A; AKTIP; RLIM; TRIM11; UBE2C; ANKIB1; RNF180; ITCHA; RNF4; TRIM6

Interacting Protein

CDC42 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC42 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC42.
PAK1; WAS

CDC42 Related Articles

Matsuda, T; Yanase, S; et al. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. IMMUNITY & AGEING 12:-(2015).
Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).