Recombinant Human CDC42 Protein, GST-Tagged

• Cat.No.: CDC42-0934H
• Product Overview: Human CDC42 full-length ORF (AAH02711, 1 a.a. - 191 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 46.75 kDa
• AA Sequence: MQTIKCVVVGDGAVGKTCLLISYTT NKFPSEYVPTVFDNYAVTVMIGGEP YTLGLFDTAGQEDYDRLRPLSYPQT DVFLVCFSVVSPSSFENVKEKWVPE ITHHCPKTPFLLVGTQIDLRDDPST IEKLAKNKQKPITPETAEKLARDLK AVKYVECSALTQKGLKNVFDEAILA ALEPPEPKKSRRCVLL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CDC42 cell division cycle 42 (GTP binding protein, 25kDa) [ Homo sapiens ]
• Official Symbol: CDC42
• Synonyms: CDC42; cell division cycle 42 (GTP binding protein, 25kDa); cell division cycle 42 (GTP binding protein, 25kD); cell division control protein 42 homolog; CDC42Hs; G25K; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; small GTP binding protein CDC42; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
• Gene ID: 998
• mRNA Refseq: NM_001039802
• Protein Refseq: NP_001034891
• MIM: 116952
• UniProt ID: P60953

Reviews

03/28/2021

Reliable protein crystallography, essential for structural studies.

09/08/2019

Exceptional protein engineering services, meets our lab's needs.

05/01/2018

Efficient peptide synthesis, crucial for our peptide research.

Q&As

How does CDC42 regulate cytoskeletal reorganization and cell morphology changes?

CDC42 controls cytoskeletal dynamics, leading to changes in cell shape and movement.

What is the impact of CDC42 on neuronal development and synaptic plasticity?

CDC42 is important in neuronal development and plays a role in forming and remodeling synaptic connections.

How do alterations in CDC42 expression or activity affect aging and age-related diseases?

Changes in CDC42 activity can impact aging processes and contribute to the development of age-related diseases.

How does CDC42 contribute to cancer cell migration, invasion, and metastasis?

CDC42 facilitates cancer progression by enhancing cell migration, invasion, and metastatic potential.

How does CDC42 influence wound healing and tissue regeneration?

CDC42 aids in wound healing and regeneration by guiding cell migration and tissue restructuring.

What role does CDC42 play in the process of cell division and cell cycle regulation?

CDC42 is crucial for cell division and cycle progression, coordinating cellular events for proper division.

What are the mechanisms by which CDC42 modulates immune cell trafficking and activation?

CDC42 regulates immune cell movement and activation, essential for immune response and surveillance.