CDC73

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CDC73

Official Full Name cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
Background CDC73 (HPRT2) is a putative tumor suppressor protein thought to bind RNA polymerase II to help inhibit cell cycle progression. Commonly referred to as parafibromin, CDC73 is expressed in endocrine tissues, kidney, heart, and skeletal muscle and is localiz
Synonyms CDC73; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); C1orf28, chromosome 1 open reading frame 28 , HRPT2, hyperparathyroidism 2 (with jaw tumor); parafibromin; hyperparathyroidism 2 protein; cell division cyc
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDC73-3933H Recombinant Human CDC73 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDC73-0959H Recombinant Human CDC73 Protein, GST-Tagged Wheat Germ GST
    Human CDC73-11020H Recombinant Human CDC73, GST-tagged E.coli GST
    Human CDC73-7645HCL Recombinant Human CDC73 293 Cell Lysate HEK293 N/A
    Human CDC73-7927H Recombinant Human CDC73, His-tagged E.coli His
    Mouse CDC73-3153M Recombinant Mouse CDC73 Protein Mammalian Cell His
    Rat CDC73-1283R Recombinant Rat CDC73 Protein Mammalian Cell His
    Rhesus Macaque CDC73-771R Recombinant Rhesus monkey CDC73 Protein, His-tagged Mammalian Cell His
    Chicken CDC73-2923C Recombinant Chicken CDC73 Mammalian Cell His
    Zebrafish CDC73-10671Z Recombinant Zebrafish CDC73 Mammalian Cell His

    CDC73 involved in several pathways and played different roles in them. We selected most pathways CDC73 participated on our site, such as Formation of the beta-catenin:TCF transactivating complex, Hedgehog on state, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC73 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Formation of the beta-catenin:TCF transactivating complex H3F3D; RBBP5; BCL9; TLE3B; TLE4; TLE2; ASH2L; LEO1; PYGO2; PYGO1
    Hedgehog on state SPOP; RPGRIP1L; IFT172; SPOPL; GPR161; MKS1; IQCE; DZIP1; EVC2; BOC
    Signal Transduction FGD2; SDR16C5; GREM2; AMOTL2A; SDR9C7; PLEKHG2; GPBAR1; NF2A; CRABP1B; PRKCHB
    Signaling by Hedgehog SPOPL; DISP2; TULP3; BOC; BBS13; EVC; IQCE; EVC2; NOTUM; CDON
    Signaling by Wnt ASH2L; CBY1; CSNK1G2; RSPO4; RSPO2; WIF1; ZNRF3; PYGO2; WLS; SOX4B
    TCF dependent signaling in response to WNT SOX9A; TNKS2; PYGO1; RNF146; RNF43; USP34; CBY1; SOX4B; SOX4A; SOX9B

    CDC73 has several biochemical functions, for example, RNA polymerase II core binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC73 itself. We selected most functions CDC73 had, and list some proteins which have the same functions with CDC73. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core binding KIAA1967; AGO2; RECQL5; CTR9; AGO1; GTF2E1; SMYD2A; PCF11; C14orf166; WACA
    protein binding SRGAP2; SENP6; RPS11; PXMP2; EIF6; FHL2; ACPL2; GYPB; HK2; ZBTB2

    CDC73 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC73 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC73.

    PAF1

    Lamoliatte, F; Caron, D; et al. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. NATURE COMMUNICATIONS 5:-(2014).

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