cdc73
Share
  • Official Full Name
  • cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
  • Background
  • CDC73 (HPRT2) is a putative tumor suppressor protein thought to bind RNA polymerase II to help inhibit cell cycle progression. Commonly referred to as parafibromin, CDC73 is expressed in endocrine tissues, kidney, heart, and skeletal muscle and is localiz
  • Synonyms
  • CDC73; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); C1orf28, chromosome 1 open reading frame 28 , HRPT2, hyperparathyroidism 2 (with jaw tumor); parafibromin; hyperparathyroidism 2 protein; cell division cyc
Cat.#:CDC73-0959HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDC73 Protein, GST-Tagged
+Inquiry
Cat.#:CDC73-11020HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC73, GST-tagged
+Inquiry
Cat.#:CDC73-7927HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDC73, His-tagged
+Inquiry
Cat.#:CDC73-3153MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDC73 Protein
+Inquiry
Cat.#:CDC73-1283RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDC73 Protein
+Inquiry
Cat.#:CDC73-771RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDC73 Protein, His-tagged
+Inquiry
Cat.#:CDC73-2923CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDC73
+Inquiry
Cat.#:CDC73-10671ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDC73
+Inquiry
Cat.#:CDC73-7645HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CDC73 293 Cell Lysate
+Inquiry

Involved Pathway

CDC73 involved in several pathways and played different roles in them. We selected most pathways CDC73 participated on our site, such as Formation of the beta-catenin:TCF transactivating complex, Hedgehog on state, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC73 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Formation of the beta-catenin:TCF transactivating complex
ASH2L; CDC73; PYGO1; BCL9L; TLE4; BCL9; H3F3D; H3F3B.1; TLE1; TLE2
Hedgehog on state
RPGRIP1L; GPR161; BOC; IFT172; GAS8; DZIP1; EVC2; CDC73; SPOPL; EVC
Signal Transduction
IFT52; UTS2; METAP1; ABHD6B; NET1; CCNT2B; PRLRB; KEL; CLPS; CXCL11.8
Signaling by Hedgehog
KIF7; SPOP; BOC; SPOPL; NOTUM1A; IFT52; BBS13; IQCE; NOTUM; CDC73
Signaling by Wnt
CCDC88C; RSPO2; CSNK1G2; KLHL12; FMNL3; TNKS; FAM123B; KREMEN2; HECW1B; BCL9L
TCF dependent signaling in response to WNT
KREMEN1; RSPO4; BCL9; CBY1; HECW1; WNT8-2; LGR6; RSPO2; PYGO2; ZNRF3

Protein Function

CDC73 has several biochemical functions, for example, RNA polymerase II core binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC73 itself. We selected most functions CDC73 had, and list some proteins which have the same functions with CDC73. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core binding
Related Protein SMYD2B; AGO2; AGO1; WAC; CTR9; SMYD3; ZFP326; KIAA1530; RECQL5; PCF11
Function protein binding
Related Protein LCAT; ZFP488; TRIP4; MAPK11; SCN11A; NDUFS1; RBM5; GHRL; CCDC167; GSTO1

Interacting Protein

CDC73 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC73 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC73.
PAF1

CDC73 Related Articles

Lamoliatte, F; Caron, D; et al. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. NATURE COMMUNICATIONS 5:-(2014).