cdk5rap2
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  • Official Full Name
  • CDK5 regulatory subunit associated protein 2
  • Background
  • CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly.
  • Synonyms
  • CDK5RAP2; CDK5 regulatory subunit associated protein 2; MCPH3, microcephaly, primary autosomal recessive 3; CDK5 regulatory subunit-associated protein 2; C48; CEP215; FLJ10867; centrosomal protein 215 kDa; centrosome-associated protein 215; CDK5 activator-binding protein C48; MCPH3; KIAA1633; DKFZp686B1070; DKFZp686D1070
Cat.#:CDK5RAP2-3208MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDK5RAP2 Protein
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Involved Pathway

CDK5RAP2 involved in several pathways and played different roles in them. We selected most pathways CDK5RAP2 participated on our site, such as Activation of BAD and translocation to mitochondria, Activation of BH3-only proteins, Anchoring of the basal body to the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5RAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of BAD and translocation to mitochondria
AKT3; YWHAQ; CDK5RAP2
Activation of BH3-only proteins
DYNLL2; YWHAQ; E2F1; AKT3; CDK5RAP2; BCL2L11
Anchoring of the basal body to the plasma membrane
NPHP1; SDCCAG8; CEP290; DCTN2; TMEM67; DCTN1A; CCDC41; TCTN3; CEP76; DYNC1I2
Apoptosis
NGF; BCL2L1; PTBP3; BID; PPP3R1; TP53; BNIP3L; PRKAR1A; BIRC2; PPP3CCA
Assembly of the primary cilium
NDE1; BBS10; PCM1; UNC119B; OFD1; NPHP3; IFT81; B9D2; DYNLRB2; CCT3
Cell Cycle
SETA; HTATIP; SFN; E2F2; NDEL1; TUBB4B; CDC25B; E2F6; YWHAG; VRK2
Cell Cycle Checkpoints
DBF4; RAD1; YWHAQ; HIST3H2BB; RAD9A; CLSPN; RAD9; MCM8; CHEK2; KAT5
Cell Cycle, Mitotic
CDT1; CEP70; PCM1; MCM10; SPC24; CETN2; CDCA5; NSL1; CDK11B; DYNC1I2

Protein Function

CDK5RAP2 has several biochemical functions, for example, calmodulin binding, microtubule binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5RAP2 itself. We selected most functions CDK5RAP2 had, and list some proteins which have the same functions with CDK5RAP2. You can find most of the proteins on our site.
Function
Related Protein
Function calmodulin binding
Related Protein KCNN1B; CNN2; CASK; PCDP1; SCN5A; RASGRF2B; GEM; RRAD; PPP3CA; RGS4
Function microtubule binding
Related Protein KCNH2A; CNN3; MAP205; MAP1S; BIRC5; ARHGEF2; MAPRE3B; MAP1LC3C; KIF18B; FMR1
Function protein complex binding
Related Protein PTPRF; KLHL8; MYO7A; MYC; IST1; ABI1; PEX26; STK11; ARRB2; TWF1
Function protein kinase binding
Related Protein POLA1; CDK5R1; TTN; TP73; TPCN2; FGR; STAT3; CEP152; GPRC5B; ELAVL1
Function transcription regulatory region DNA binding
Related Protein TAF7L; MTERFD3; GLI1; REST; SOX5; TCF7L1A; SFPQ; PHB; HIVEP2A; NR1D1
Function tubulin binding
Related Protein GPAA1; STMN1A; LRRK2; KIF14; TTLL4; ATF5; RPS3; STMN1B; STMN4L; FYN

Interacting Protein

CDK5RAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5RAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5RAP2.
TBC1D31; PCM1; PDE4DIP; SEC16A; SIPA1L3; PCNT; PRKAR2A; PRKACA; PRKACB; DYNLL1; PCM1; KIAA0753; CEP170; MIB1; AKAP9; MYO10; CEP72; RRBP1; PGAP2; CEP131