CDK5RAP2 Protein, CDK5 regulatory subunit associated protein 2

CDK5RAP2

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CDK5RAP2

Official Full Name CDK5 regulatory subunit associated protein 2
Background CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly.
Synonyms CDK5RAP2; CDK5 regulatory subunit associated protein 2; MCPH3, microcephaly, primary autosomal recessive 3; CDK5 regulatory subunit-associated protein 2; C48; CEP215; FLJ10867; centrosomal protein 215 kDa; centrosome-associated protein 215; CDK5 activator-binding protein C48; MCPH3; KIAA1633; DKFZp686B1070; DKFZp686D1070
    • Species :
    • Mouse
    • Source :
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse CDK5RAP2-3208M Recombinant Mouse CDK5RAP2 Protein Mammalian Cell His

    CDK5RAP2 involved in several pathways and played different roles in them. We selected most pathways CDK5RAP2 participated on our site, such as Activation of BAD and translocation to mitochondria, Activation of BH3-only proteins, Anchoring of the basal body to the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5RAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of BAD and translocation to mitochondria CDK5RAP2; YWHAQ; AKT3
    Activation of BH3-only proteins AKT3; CDK5RAP2; E2F1; DYNLL2; BCL2L11; YWHAQ
    Anchoring of the basal body to the plasma membrane ACTR1A; CEP57; CEP72; CEP290; CEP164; DCTN1A; TUBB4A; CEP135; ODF2; CCDC123
    Apoptosis PRKACG; BCL2L1; TP53; FAS; CYCSB; DSG2; PLECA; TNFRSF10B; IL1A; DBNLB
    Assembly of the primary cilium CCT5; IFT27; SCLT1; SSNA1; IFT43; CSNK1E; CCT8; DYF-1; PKD1; KIF17
    Cell Cycle CDKN2A; CENPI; CDKN2B; YWHABA; TUBGCP2; NEK6; HIST4H4; SMC1AL; TUBGCP3; MCM4
    Cell Cycle Checkpoints CDK2; RAD9B; TP53BP1; RAD50; KAT5; YWHAQ; UIMC1; MCM10; HIST4H4; CLSPN
    Cell Cycle, Mitotic CEP290; CSNK1D; CDK4; CSNK2A1; CENPE; CTDNEP1B; NEK9; AHCTF1; RANGAP1B; CEP78

    CDK5RAP2 has several biochemical functions, for example, calmodulin binding, microtubule binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5RAP2 itself. We selected most functions CDK5RAP2 had, and list some proteins which have the same functions with CDK5RAP2. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding CNN3A; PLA2G6; SPTAN1; RRAD; EPB41; NOS3; IQCB1; NOS1; SLC14A2; ADCY3
    microtubule binding ARHGEF2; CLIP1; WDR81; GAS2L2; MAP4; WHAMM; AKAP1; GABARAPL2; MARK4; KIF1B
    protein complex binding ATG101; CCND1; RELA; ING2; PPIB; ATP6V0D1; STRN4; LRRC16A; KAT2B; RIPK3
    protein kinase binding GSTP2; FOXO3; CCNL1B; TSACC; IBTK; CLTC; SNAP91; CALM3; SPRED2; NEFH
    transcription regulatory region DNA binding ARID5B; SOX17; TAF7; ZNF567; HIVEP2A; TP63; NKX3-1; XBP1; OVOL2; GLI1
    tubulin binding GPAA1; STMN1; ALDOA; STMN1B; STMN3; STMN4; FYN; MTAP4; PRNP; LRRK2

    CDK5RAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5RAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5RAP2.

    TBC1D31; PCM1; PDE4DIP; SEC16A; SIPA1L3; PCNT; PRKAR2A; PRKACA; PRKACB; DYNLL1; PCM1; KIAA0753; CEP170; MIB1; AKAP9; MYO10; CEP72; RRBP1; PGAP2; CEP131

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