CDK5RAP2
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Official Full Name
CDK5 regulatory subunit associated protein 2 -
Overview
CDK5RAP2 (CDK5 regulatory subunit-associated protein 2) potentially regulates CDK5 activity by interacting with CDK5R1. CDK5 is a brain specific cyclin-dependent kinase important to mammalian brain development. Studies implicate CDK5RAP2 involvement in centrosome directed production of microtubules and mitotic spindle formation during neuronal cell division. Mutations in CDK5RAP2 have been linked to the developmental disorder autosomal recessive primary microcephaly. -
Synonyms
CDK5RAP2;CDK5 regulatory subunit associated protein 2;MCPH3, microcephaly, primary autosomal recessive 3;CDK5 regulatory subunit-associated protein 2;C48;CEP215;FLJ10867;centrosomal protein 215 kDa;centrosome-associated protein 215;CDK5 activator-binding protein C48;MCPH3;KIAA1633;DKFZp686B1070;DKFZp686D1070
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CDK5RAP2-3208M | Recombinant Mouse CDK5RAP2 Protein | Mammalian Cells | Mouse | His |
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| CDK5RAP2-1529M | Recombinant Mouse CDK5RAP2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CDK5RAP2-1529M-B | Recombinant Mouse CDK5RAP2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
CDK5RAP2 involved in several pathways and played different roles in them. We selected most pathways CDK5RAP2 participated on our site, such as Activation of BAD and translocation to mitochondria,Activation of BH3-only proteins,Anchoring of the basal body to the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK5RAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | IFT122,EXOC8,IFT81,CCT3,CLUAP1,NEDD1,TUBB4B,WDR35,CSNK1E,FGFR1OP |
| Cell Cycle Checkpoints | CHEK1,RAD1,RAD50,CDKN1B,BRE,CDK2,BABAM1,UIMC1,BRCC3,RAD9B |
| Anchoring of the basal body to the plasma membrane | NPHP4,NDE1,CEP63,NPHP1,ACTR1A,TMEM67,MARK4,MKS1,TUBB4B,CEP89 |
| Activation of BH3-only proteins | BCL2L11,AKT3,YWHAQ,E2F1,DYNLL2 |
| Apoptosis | PLEC,STK26,BIRC3,PRKAR2B,TNFRSF10C,HIST1H1E,IL1R1,BCL2,CASP9,AIFM1 |
| Cell cycle | MLF1IP,ORC1,TFDP2,CSNK2A2,LIN37,ORC4,CDKN1BA,NEK6,CEP72,TUBB4B |
| Activation of BAD and translocation to mitochondria | AKT3,YWHAQ |
| Cell Cycle, Mitotic | SPC25,SETB,CDKN2D,MIS12,CTDNEP1,CDCA5,CDK7,CENPH,CSNK2A1,SKA1 |
Protein Function
CDK5RAP2 has several biochemical functions, for example, calmodulin binding,microtubule binding,protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK5RAP2 itself. We selected most functions CDK5RAP2 had, and list some proteins which have the same functions with CDK5RAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | NCK2,VAMP2,KAT6B,NASP,NCKAP1L,COG2,ULK1,RPTOR,AP2B1,ABI2 |
| microtubule binding | AKAP1,SBDS,MAP6D1,CHP,SKA1,CRYAB,KIF22,MTAP4,ZFP207,TUBGCP5 |
| protein kinase binding | ATF2,GATA4,CDKN2B,TRIB3,CLTC,RELA,PLK1,HDAC7,PTPRC,RPS6 |
| transcription regulatory region DNA binding | GABPA,ATF5,RFX3,SOX7,CREB3L2,LEF1,TBP,CDK9,KLF2A,TAF7L |
| tubulin binding | CLIP1,DAG1,AGBL4,RPS3,VBP1,ALDOA,STMN3,TPR,IFT81,TPPP |
| calmodulin binding | CAMK1G,CNN3B,PLCB1,CAMSAP1L1,CASK,MIP,KCNN1A,MARCKSL1B,C2orf62,PHKG2 |
Interacting Protein
CDK5RAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK5RAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK5RAP2.
TBC1D31;PCM1;PDE4DIP;SEC16A;SIPA1L3;PCNT;PRKAR2A;PRKACA;PRKACB;DYNLL1;PCM1;KIAA0753;CEP170;MIB1;AKAP9;MYO10;CEP72;RRBP1;PGAP2;CEP131
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