clint1
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  • Official Full Name
  • clathrin interactor 1
  • Background
  • This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • CLINT1; clathrin interactor 1; CLINT; ENTH; EPNR; KIAA0171; epsinR; epsin 4; enthoprotin; epsin-related protein; clathrin interacting protein localized in the trans-Golgi region; EPN4; FLJ46753
Cat.#:CLINT1-2021HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CLINT1 Protein (1-625 aa), His-tagged
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Cat.#:CLINT1-1485HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CLINT1 Protein, GST-tagged
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Cat.#:CLINT1-3257HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CLINT1 Protein, His-tagged
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Cat.#:CLINT1-2324CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CLINT1
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Cat.#:CLINT1-7444HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CLINT1 293 Cell Lysate
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Involved Pathway

CLINT1 involved in several pathways and played different roles in them. We selected most pathways CLINT1 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLINT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Clathrin derived vesicle budding
DNM2; AP1G1; CPD; PICALM; TCEAL4; APPA; SNX9A; PICALMA; BLOC1S3; AP4B1
Golgi Associated Vesicle Biogenesis
FTH1A; PICALMA; AP1S1; CLINT1; TFR1B; SH3D19; CNO; FTH1B; AP1S3A; SNX9B
Membrane Trafficking
NAPAA; NAPG; TFR1B; SNAPIN; COPE; TPD52; NSFA; GJA5; STXBP3; GJC1
Vesicle-mediated transport
CLINT1; GJA4; LOC479668; SEC22C; BLOC1S4; PPP6C; TFR1B; AP4B1; CPD; SCFD1
trans-Golgi Network Vesicle Budding
CLINT1; SH3D19; CPD; PLDN; SNX9B; TCEAL4; PICALMA; YIPF6; TBC1D8B; HIP1RB

Protein Function

CLINT1 has several biochemical functions, for example, clathrin binding, lipid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLINT1 itself. We selected most functions CLINT1 had, and list some proteins which have the same functions with CLINT1. You can find most of the proteins on our site.
Function
Related Protein
Function clathrin binding
Related Protein SYT11A; LRRK2; SYTL4; SYT8; DOC2D; SYT9; SYT10; SYT9B; SYT15; SCLT1
Function lipid binding
Related Protein SEC14L4; MTTP; UNC119; PACSIN3; Alb; FAM123C; PAQR5B; COQ9; APOEB; FABP7A
Function protein binding
Related Protein C14orf93; USP1; PPP2R1A; WLS; CHTOP; PLEKHG4; RNF7; DPP3; CDKN2AIP; KRT79

Interacting Protein

CLINT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLINT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLINT1.
Ap1g1; MAP1LC3B; GABARAPL1; MAP1LC3A; GABARAP; GABARAPL2; MAP1LC3C

CLINT1 Related Articles

Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).