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Official Full Name ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Background This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with progressive epilepsy with mental retardation (EMPR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.
Synonyms CLN8; ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); C8orf61, chromosome 8 open reading frame 61 , EPMR; protein CLN8; FLJ39417; EPMR; C8orf61
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLN8-38H Recombinant Human CLN8 protein, His-tagged E.coli His
    Rat CLN8-1457R Recombinant Rat CLN8 Protein Mammalian Cell His
    Rhesus Macaque CLN8-914R Recombinant Rhesus monkey CLN8 Protein, His-tagged Mammalian Cell His
    Chicken CLN8-2762C Recombinant Chicken CLN8 Mammalian Cell His
    Zebrafish CLN8-6451Z Recombinant Zebrafish CLN8 Mammalian Cell His

    CLN8 involved in several pathways and played different roles in them. We selected most pathways CLN8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLN8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    CLN8 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CLN8 itself. We selected most functions CLN8 had, and list some proteins which have the same functions with CLN8. You can find most of the proteins on our site.

    Function Related Protein

    CLN8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLN8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLN8.

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