CPNE1
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Official Full Name
copine I
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Overview
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. -
Synonyms
CPNE1; copine I; copine-1; CPN1; Copine 1; Copine1; CopineI; COPN 1; COPN1; CPN 1; CPNE 1; MGC1142; OTTHUMP00000030775; OTTHUMP00000030776; OTTHUMP00000030778; OTTHUMP00000030784; OTTHUMP00000196688; OTTHUMP00000199602; OTTHUMP00000204169;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- C
- His
- N
- Myc
- DDK
- GST
- His (Fc)
- Avi
- Myc|DDK
- N/A
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
CPNE1 involved in several pathways and played different roles in them. We selected most pathways CPNE1 participated on our site, such as Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPNE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid biosynthesis | PLA2G16;GPAT2;CPNE7;PTPMT1;PLB1;ABHD3;PITPNB;AWAT2;BCHE |
| Metabolism | ACOT8;AKAP5;CYP17A1;TACO1;BRP44;MED25;GYG1B;SLC27A2A;IVD |
| Metabolism of lipids and lipoproteins | AKR1C21;ARSD;CYP2V1;PPARGC1B;ACOT11A;CDIPT;AKR1C6;MTF1;CHKA |
| Phospholipid metabolism | CDS1;SACM1LB;ABHD3;CEPT1A;SACM1L;ARF3;CPNE7;PLD6;TPTE |
CPNE1 has several biochemical functions, for example, NF-kappaB binding, calcium ion binding, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CPNE1 itself. We selected most functions CPNE1 had, and list some proteins which have the same functions with CPNE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NF-kappaB binding | RNF25;CDKN2A;HDAC2;FOXP3;HIF1AN;NFKBID;SNAI1A;HSPA6;FAF1 |
| calcium ion binding | MYL12B;EEF2K;F7;PTBP3;PPP3R1;CAPN9;S100G;PLSCR4;S100A7A |
| calcium-dependent phospholipid binding | ANXA13;SYT5;SYT11A;ANXA13L;SYT17;SYT12;ANXA1B;ANXA11B;ANXA2 |
| endopeptidase activity | Ren1;ACE;ELANE;PSMA6A;PSMB2;HTRA3;PSMA7;PSMB11;TMEM59 |
| phosphatidylserine binding | FCHO2;SCARB1;CPNE1;MFGE8;RPE65;MARK1;JPH2;AP1S2;THBS1 |
| protein binding | RAB38;MED1;SOX9;KCNJ3;MEIOB;FAM118B;NTN1;ACCS;HDC |
| protein homodimerization activity | ZNF174;VPS24;TLR13;CHKA;ENO2;OSTA;PVR;GHR;CCBL1 |
| transporter activity | HIATL1;CRABP1B;AQP8B;Abca2;TAP2;FABP10A;SLC2A3A;FXYD2;OSTB |
CPNE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPNE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPNE1.
YWHAZ; UIMC1; BUB3; STK3; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; FN1; ARRB2
- Q&As
- Reviews
Q&As (7)
Ask a questionIt binds to calcium ions, facilitating its interaction with phospholipids and proteins.
Genetic alterations in CPNE1 have been associated with various types of cancer.
In neurons, CPNE1 is believed to play a role in synaptic function and plasticity.
CPNE1 is involved in calcium-dependent membrane interactions and cellular signaling.
CPNE1 shows a broad expression pattern, including in neural and cancerous tissues.
CPNE1 has been found to be upregulated in certain cancers, promoting tumor progression.
Research is focused on understanding its role in cancer, and it’s being explored as a potential therapeutic target.
Customer Reviews (3)
Write a reviewReliable results, quality product.
Worked great, fast shipping.
Very happy with purchase.
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