CSPG4 Protein, chondroitin sulfate proteoglycan 4

CSPG4

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CSPG4

Official Full Name chondroitin sulfate proteoglycan 4
Background A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
Synonyms CSPG4; chondroitin sulfate proteoglycan 4; NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG; chondroitin sulfate proteoglycan NG2; melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4 (melanoma-associated);
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • NS0
    • Tag :
    • His
    • GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CSPG4-1533H Recombinant Human CSPG4 protein, His-tagged E.coli His
    Human CSPG4-15H Recombinant Human CSPG4 protein, His-tagged NS0 His
    Rat Cspg4-1534R Recombinant Rat Cspg4 protein, His-tagged E.coli His
    Rat Cspg4-1535R Recombinant Rat Cspg4 protein, His & GST-tagged E.coli His/GST
    Rat CSPG4-1639R Recombinant Rat CSPG4 Protein Mammalian Cell His

    CSPG4 involved in several pathways and played different roles in them. We selected most pathways CSPG4 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, CS/DS degradation, Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSPG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    A tetrasaccharide linker sequence is required for GAG synthesis GPC1B; CSPG5B; AGRN; VCAN; NCAN; GPC1A; Gpc2; GPC5A; VCANB; BGN
    CS/DS degradation DCN; CSPG5B; NCAN; CSPG5; BGNB; VCANB; BCAN; VCAN; BGNA; BGN
    Chondroitin sulfate biosynthesis UST; BGN; B3GAT2; NCAN; BGNB; CSPG5B; VCAN; CHST9; VCANB; BCAN
    Chondroitin sulfate/dermatan sulfate metabolism CHST9; DSEL; BCAN; VCAN; BGNB; UST; GPC1B; CSPG4; CHST14; GPC1A
    Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG4; VCAN; CSPG5; GPC5; AGRN; DCN; GPC6; NCAN; BGN; BCAN
    Defective B3GAT3 causes JDSSDHD BGN; NCAN; CSPG5; BCAN; DCN; VCAN; GPC6; AGRN; CSPG4; GPC5
    Defective B4GALT7 causes EDS, progeroid type BCAN; DCN; BGN; AGRN; CSPG4; NCAN; GPC6; VCAN; GPC5; CSPG5
    Defective CHST14 causes EDS, musculocontractural type BCAN; DCN; CSPG4; BGN; CSPG5

    CSPG4 has several biochemical functions, for example, protein kinase binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSPG4 itself. We selected most functions CSPG4 had, and list some proteins which have the same functions with CSPG4. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase binding MAP3K13; MSN; PARP1; HIF1A; ADRA2A; TRAP1; RNF138; SCN5A; KCNA5; CDC42
    signal transducer activity GPR141; PLCZ1; TAAR14D; GPR34A; CXCR4A; TAS2R201.1; OLFCW1; LGR4; OPN3; PDCD1

    CSPG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSPG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSPG4.

    ganglioside_gm1; ATF7IP; Gspt1; SORT1; Tbc1d7; ZNF644

    Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
    Warta, R; Herold-Mende, C; et al. Reduced promoter methylation and increased expression of CSPG4 negatively influences survival of HNSCC patients. INTERNATIONAL JOURNAL OF CANCER 135:2727-2734(2014).

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