cyp2c18
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  • Official Full Name
  • cytochrome P450, family 2, subfamily C, polypeptide 18
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • CYP2C18; cytochrome P450, family 2, subfamily C, polypeptide 18; CYP2C17, cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 18; cytochrome P450 2C18; CPCI; CYP2C; P450IIC17; CYP2C 18; (S) mephenytoin hydroxylase associated cytochrome P450; CYP2C17; CYPIIC18; Cytochrome P450 family 2 subfamily C polypeptide 18; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 17; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 18; Flavoprotein linked monooxygenase; Microsomal monooxygenase; Unspecific monooxygenase; cytochrome P450-6B/29C; flavoprotein-linked monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; P450-6B/29C
Cat.#:CYP2C18-2261HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2C18 Protein, GST-tagged
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Cat.#:CYP2C18-3396HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CYP2C18 Protein, MYC/DDK-tagged
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Cat.#:CYP2C18-1147RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2C18 Protein, His-tagged
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Cat.#:CYP2C18-1153CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CYP2C18
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Cat.#:CYP2C18-434HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CYP2C18 cell lysate
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Involved Pathway

CYP2C18 involved in several pathways and played different roles in them. We selected most pathways CYP2C18 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
FDX1; CYP2Y3; COMT; GSTO2; CYP8B2; CYP11B2; ACY3.1; CYP2K16; CYP26A1; CYP11A1
Chemical carcinogenesis
GSTM6; GSTA5; GSTT1; GSTM4; CYP2C54; CYP3A7; SULT1A1; FAM84B; UGT1A9; ALDH3B2
Cytochrome P450 - arranged by substrate type
CYP2K8; CYP1A1; CYP2C8; CYP51A1; CYP2K22; CYP2W1; CYP3A7-CYP3AP1; CYP2A6; CYP2F1; CYP7A1
FOXA1 transcription factor network
NR2F2; CYP2C18; POU2F1; DSCAM; AP1B1; TFF1; CEBPB; NFIC; FOXA1; CC10
Metabolic pathways
ALG10; AK7; ALOX5; UGT8; ACAA2; DLDH; ADK; GPI; ABP1; ENPP3
Metabolism
ACY3.1; STAB2; SULT1C4; PDZD11; TCN1; UGT1B5; SLC6A12; GPHN; ATP5H; AFMID
Phase 1 - Functionalization of compounds
CYP2N13; ADH8B; CYP2AD3; CYP3A7; CYP2C18; CYP4T8; CYP3A7-CYP3AP1; CYP26A1; CYP46A1; CYP8B2
Retinol metabolism
CYP3A65; RDH8; RPE65C; CYP4A14; CYP2C55; AOX1; HSD17B6; LRATA; ADH2-1; CYP2C50

Protein Function

CYP2C18 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C18 itself. We selected most functions CYP2C18 had, and list some proteins which have the same functions with CYP2C18. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid epoxygenase activity
Related Protein CYP2AD2; CYP2AA9; CYP2C8; CYP4F18; CYP2P10; CYP2A6; CYP2A12; CYP2C55; CYP4F2; CYP2AA3
Function aromatase activity
Related Protein CYP4B1; CYP2D9; CYP2D26; CYP2D6; CYP2C39; CYP2C18; CYP2C37; CYP2C54; CYP3A5; CYP1D1
Function heme binding
Related Protein HBE1; CYP1B1; CYP2K16; CYP2C38; PTGS2; CYCS; MPX; CYP4V2; CYP4F12; CYP2Y3
Function iron ion binding
Related Protein TET1; OGFOD3; CYP21A1; CYP2AA3; CYP21A2; SC4MOL; HBA1; CYP2C37; TMLHE; BBOX1
Function monooxygenase activity
Related Protein CYP3A7; TPH1A; CYP2X8; MICAL2B; CYP2B6; TPH1B; CYP2J5; CYP3A4; CYP21A1; YWHAQA
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2C50; CYP3C1; CYP2J6; CYP2X7; CYP2J2; CYP2AA8; CYP2AA12; CYP2AA6; CYP2P7; CYP2W1
Function oxygen binding
Related Protein CYP2W1; CYP19A1; CYP2S1; CYP2A7; CYP3A7; NGB; HBAE1; HBE1; CYP2C9; CYP2V1
Function steroid hydroxylase activity
Related Protein CYP2D6; CYP2R1; CYP2X10.2; CYP2V1; CYP2K19; CYP2W1; CYP2C38; CYP2X7; CYP2K18; CYP2K16

Interacting Protein

CYP2C18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C18.
A2M; SDC2; ECSIT

CYP2C18 Related Articles

Tsuchida, T; Zheng, YW; et al. The Development of Humanized Liver With Rag1 Knockout Rats. TRANSPLANTATION PROCEEDINGS 46:1191-1193(2014).
Redlich, G; Zanger, UM; et al. Distinction between Human Cytochrome P450 (CYP) Isoforms and Identification of New Phosphorylation Sites by Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH 7:4678-4688(2008).