cyp2c8
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  • Official Full Name
  • cytochrome P450, family 2, subfamily C, polypeptide 8
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
  • Synonyms
  • CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; CYPIIC8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; Flavoprotein linked monooxygenase; Microsomal monooxygenase; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; Xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; MP-12/MP-20
Cat.#:CYP2C8-11773HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C8, His-tagged
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Cat.#:CYP2C8-120HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP2C8, GST-tagged
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Cat.#:CYP2C8-384HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2C8
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Cat.#:CYP2C8-1150RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2C8 Protein, His-tagged
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Cat.#:CYP2C8-7114HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2C8 293 Cell Lysate
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Cat.#:Kit-0895Tag:
Source (Host):Species:
Product nameCYP2C8 Green Screening Kit
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Involved Pathway

CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CYP2P8; CYP4F11; GPX2; ALOX12B; HPGDS; CYP4A11; CBR3; CYP2B6; PTGR1; PTGS1
Biological oxidations
CYP21A2; TPMT.2; CYP3A5; SLC26A2; CYP2K6; CYP2E1; CYP19A1; AS3MT; SULT1C4; CYP51A1
CYP2E1 reactions
CYP2C8; CYP2D6; CYP2S1; CYP2C9; CYP2A6; CYP2B6; CYP2A7; CYP2C19; CYP2A13; CYP2E1
Chemical carcinogenesis
CBR1; GSTP2; CYP2C39; CYP3A5; ALDH3B1; CYP2C9; UGT2A2; GSTA3; CYP3A41B; CYP1B1
Cytochrome P450 - arranged by substrate type
CYP2A7; CYP2K6; CYP27A1; CYP24A1; CYP2C18; CYP2C19; CYP2U1; CYP17A1; CYP2W1; CYP2R1
Drug metabolism - cytochrome P450
CYP2D6; ADH1C; ADH2-1; ADH5; CYP2B6; ADH1B; CYP2A6; CYP3A5; ADH1A; ADH6
Linoleic acid metabolism
CYP2P7; CYP2J6; CYP3A41B; CYP2C19; CYP2J5; PLA2G2D; PLB1; PLA2G1B; CYP2C9; CYP3A41A
Metabolic pathways
TDO2B; HSD17B7; HYKK; PET112L; AUH; MT-ATP6; TK2; CHIA; CYP19A1; IDI1

Protein Function

CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.
Function
Related Protein
Function (R)-limonene 6-monooxygenase activity
Related Protein CYP2C8; CYP2C19; CYP2C9
Function (S)-limonene 6-monooxygenase activity
Related Protein CYP2C8; CYP2C19; CYP2C9
Function (S)-limonene 7-monooxygenase activity
Related Protein CYP2C19; CYP2C8; CYP2C9
Function arachidonic acid epoxygenase activity
Related Protein CYP2C55; CYP2C39; CYP2F1; CYP4F2; CYP2F2; CYP2S1; CYP2C54; CYP2AA9; CYP2J6; CYP2AA3
Function enzyme binding
Related Protein RPA2; BCL10; TRP53; MST1R; TUT1; DNM2; USP22; H2AFX; TARBP2; CD40
Function heme binding
Related Protein HBE; GUCY1A3; CYP4B1; CYP2A12; CYP4F12; HBAA1; CYP4V7; NGB; CYP2F2; NOX4
Function iron ion binding
Related Protein CYP2AA3; ALOX5A; CYP2C37; FA2H; CYP1C2; CYP2K16; CYP2P8; CYP2Y3; P4HA1B; CYP4A12A
Function monooxygenase activity
Related Protein FMO2; CYP2AA12; CYP2K16; CYP1A2; CYP2P8; CYP2X10.2; YWHAQB; CYP8B1; CYP2P7; CYP2C38
Function oxidoreductase activity
Related Protein OSGIN2; FADS3; CYP2J6; ETFDH; ACOXL; CYP2AD3; AKR1A1A; SDR42E1; RYROXD1; CYP3C4
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2P8; CYP19A1; CYP2P6; CYP2B6; CYP2D6; CYP2U1; CYP2AA6; CYP2AA9; CYP2AA4; CYP2B19
Function oxygen binding
Related Protein HBAA1; CYP2X10.2; CYP1B1; HBBE1.1; CYP2N13; CYP2C19; CYP2Y3; HBE; CYP4B1; CYP2AA8
Function steroid hydroxylase activity
Related Protein CYP2C38; CYP2Y3; CYP2AA12; CYP2AA2; CYP2AA1; CYP2P8; CYP2C54; CYP2X8; CYP2A4; CYP46A1.4

Interacting Protein

CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.
PGRMC1; A2M; APOE; DNAJB1; LONP1; BLMH; RIN3; MAST1; GABARAPL1; MAP1LC3A

CYP2C8 Related Articles

Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).