cyp2c8
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  • Official Full Name
  • cytochrome P450, family 2, subfamily C, polypeptide 8
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
  • Synonyms
  • CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; CYPIIC8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; Flavoprotein linked monooxygenase; Microsomal monooxygenase; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; Xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; MP-12/MP-20
Cat.#:CYP2C8-11773HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C8, His-tagged
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Cat.#:CYP2C8-120HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP2C8, GST-tagged
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Cat.#:CYP2C8-384HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2C8
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Cat.#:CYP2C8-1150RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2C8 Protein, His-tagged
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Cat.#:CYP2C8-7114HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2C8 293 Cell Lysate
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Cat.#:Kit-0895Tag:
Source (Host):Species:
Product nameCYP2C8 Green Screening Kit
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Involved Pathway

CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
PLA2G4F; PLA2G2D; PLA2G4B; CYP1A2; ALOX5B.3; MAPKAPK2B; PLA2G2A; CYP2U1; CYP2AD6; PTGES3B
Biological oxidations
UGT1B3; CYP2K16; CYP26A1; CYP27B1; CYP11A1; ADH6; CYP2AD3; CYP2A7; CYP1A2; SULT1ST6
CYP2E1 reactions
CYP2C9; CYP2C8; CYP2A7; CYP2E1; CYP2A13; CYP2F1; CYP2D6; CYP2B6; CYP2S1; CYP2C19
Chemical carcinogenesis
SULT1A1; CYP2B19; ADH1B; CYP2C38; CYP2C55; UGT1A6; UGT1A7C; CYP2C50; CYP2C8; CYP2C18
Cytochrome P450 - arranged by substrate type
CYP2R1; CYP1A1; CYP46A1; FAM84B; CYP11A1; CYP2AD2; CYP4A11; CYP2A6; CYP24A1; CYP3C1
Drug metabolism - cytochrome P450
ADH7; ADH4; CYP2C8; ADH2-2; CYP3A5; CYP2E1; CYP2A6; GSTK1; CYP2C9; ADH1A
Linoleic acid metabolism
CYP2C37; PLB1; CYP3A41A; CYP2C9; PLA2G4F; CYP2C54; CYP2P7; DHRS13L1; CYP2P6; CYP3A65
Metabolic pathways
MGAT1A; CYP21A2; ATP6V0D1; PHGDH; NDST3; STT3B; IMPDH1B; PIK3C2G; PLCD3A; MBOAT2B

Protein Function

CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.
Function
Related Protein
Function (R)-limonene 6-monooxygenase activity
Related Protein CYP2C8; CYP2C9; CYP2C19
Function (S)-limonene 6-monooxygenase activity
Related Protein CYP2C19; CYP2C9; CYP2C8
Function (S)-limonene 7-monooxygenase activity
Related Protein CYP2C19; CYP2C9; CYP2C8
Function arachidonic acid epoxygenase activity
Related Protein CYP2A6; CYP2S1; CYP2C37; CYP2N13; CYP2P10; CYP2P6; CYP2AA4; CYP4A10; CYP2C38; CYP2F2
Function enzyme binding
Related Protein BRCA1; RAD9; FOXO4; RPA3; APP; PPP3CB; Il6ra; TSPAN5; TRP53; UBE2I
Function heme binding
Related Protein HBZ; HBAA1; CYP2K6; CYP2A13; CYP3A43; HRG; CYP2P10; SUOX; CYBB; CYP4F12
Function iron ion binding
Related Protein HBG2; CYP3A43; IRGM1; CYP3A7; CYP4A14; JMJD6; BBOX1; HBAE3; P4HA1A; CYP2AD6
Function monooxygenase activity
Related Protein BCMO1; CYP39A1; CYP2AD6; CYP2E1; CYP2N13; CYP4A14; CYP2AD3; CYP4F22; YWHABL; CYP2C19
Function oxidoreductase activity
Related Protein AKR1C21; CYP2C8; SC4MOL; CYP4A14; GLUD1B; GPX6; CYP2AA6; KDM5BB; SERPINB1A; P4HA1B
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2U1; CYP2D6; CYP2AA2; CYP2C55; CYP2A13; CYP2K16; CYP2V1; CYP2C19; CYP2R1; CYP2AA8
Function oxygen binding
Related Protein BA1; CYP2F2; CYP2A12; CYGB; CYP2AA2; CYP2A7; CYP4B1; CYP2P10; HBB-B2; HBB-Y
Function steroid hydroxylase activity
Related Protein CYP2P7; CYP2E1; BRSK2; CYP2AD6; CYP2B19; CYP2C18; CYP2AA7; CYP2AA2; CYP2K16; FAM84B

Interacting Protein

CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.
PGRMC1; A2M; APOE; DNAJB1; LONP1; BLMH; RIN3; MAST1; GABARAPL1; MAP1LC3A

CYP2C8 Related Articles

Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).