CYP2C8

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CYP2C8

Official Full Name cytochrome P450, family 2, subfamily C, polypeptide 8
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
Synonyms CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; CYPIIC8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; Flavoprotein linked monooxygenase; Microsomal monooxygenase; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; Xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; MP-12/MP-20
    • Species :
    • Cynomolgus
    • Human
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus CYP2C8-124C Recombinant Cynomolgus CYP2C8 Protein E. coli
    Human CYP2C8-14H Recombinant Human CYP2C8 Protein E.coli
    Human CYP2C8-76H Recombinant Human CYP2C8 Protein E. coli
    Human CYP2C8-11773H Recombinant Human CYP2C8, His-tagged E.coli His
    Human CYP2C8-120H Recombinant Human CYP2C8, GST-tagged Wheat Germ GST
    Human CYP2C8-384H Recombinant Human CYP2C8 Insect Cell N/A
    Human CYP2C8-7114HCL Recombinant Human CYP2C8 293 Cell Lysate HEK293 N/A
    Rhesus Macaque CYP2C8-1150R Recombinant Rhesus monkey CYP2C8 Protein, His-tagged Mammalian Cell His
    Kit-0895 CYP2C8 Green Screening Kit N/A

    CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism GGT5A; PLA2G5; PTGES3A; CBR3; CYP4A11; PLA2G1B; CYP4F18; PTGIS; CYP4F3; AKR1C21
    Biological oxidations CYP2N13; AKR1A1; CYP2F1; NAT2; CYP2D6; ADH6; BPNT1; SLC26A2; SULT4A1; SLC35B3
    CYP2E1 reactions CYP2F1; CYP2A7; CYP2A6; CYP2C8; CYP2Y3; CYP2C9; CYP2C19; CYP2E1; CYP2D6; CYP2B6
    Chemical carcinogenesis GSTP1; CYP2C9; HSD11B1; CYP3A41A; NAT2; ADH4; ADH7; CYP2C70; Nat3; CYP3A43
    Cytochrome P450 - arranged by substrate type CYP27B1; CYP4B1; CYP2A6; FDXR; CYP3A7; CYP26A1; CYP4F22; CYP2C9; CYP2W1; CYP2K8
    Drug metabolism - cytochrome P450 CYP2B6; CYP3A5; CYP2D6; ADH7; ADH1B; ADH1C; CYP2E1; ADH6; CYP2C8; ADH5
    Linoleic acid metabolism CYP3A41B; CYP2C50; PLB1; CYP2P8; PLA2G2F; PLA2G2A; PLA2G12B; CYP2C9; CYP2C39; CYP3A65
    Metabolic pathways PIGB; PMVK; ALPP; MCCC1; GAD1B; NT5C3B; UPB1; CMPK1; PIGF; TBXAS1

    CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.

    Function Related Protein
    (R)-limonene 6-monooxygenase activity CYP2C8; CYP2C9; CYP2C19
    (S)-limonene 6-monooxygenase activity CYP2C19; CYP2C9; CYP2C8
    (S)-limonene 7-monooxygenase activity CYP2C9; CYP2C19; CYP2C8
    arachidonic acid epoxygenase activity CYP2V1; CYP2AA1; CYP2E1; CYP2AA12; CYP2F1; CYP4F2; CYP2F2; CYP2A4; CYP2D9; CYP2A12
    enzyme binding TAF10; ADORA2A; Il6ra; ESR1; AKIRIN2; BTG1; PTPN1; CLSTN2; IL6R; PTEN
    heme binding CYB5B; CYP2J2; AMBP; CYGB2; STC2; CYP7B1; CYP2B19; CYP2A6; CYP2AA3; HBA-A2
    iron ion binding CYP17A1; HBZ; CYP2Y3; EGLN1; CYP46A1.3; CYP2P8; TYW5; P4HA1B; HBAD; CYP2AA4
    monooxygenase activity CYP8B1; CYP2X10.2; BCO1; CYP3C1L2; CYP2AA4; CYP4F3; CYP19A1A; CYP2AA12; CYP2AA8; MOXD1L
    oxidoreductase activity DHRS13A.1; CYP2AD2; TXNRD3; CYBASC3; CYP2C8; CYP2AA3; DIO3A; CYP3A5; ALOX12E; FADS1
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2AD2; CYP2D6; CYP2N13; CYP2C39; CYP2U1; CYP2C37; CYP2AA4; CYP2A6; CYP2D10; CYP2AA2
    oxygen binding CYP2AD6; CYP2C70; CYP2C8; CYGB2; CYP17A1; CYGB; HBBE1.1; HBG2; CYP2P9; CYP1A1
    steroid hydroxylase activity CYP2J6; CYP2C38; CH25H; CYP2K17; CYP2C39; CYP2U1; CYP2C37; CYP2AD3; CYP2K6; CYP2R1

    CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.

    PGRMC1; A2M; APOE; DNAJB1; LONP1; BLMH; RIN3; MAST1; GABARAPL1; MAP1LC3A

    Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
    Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).

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