cyp2c8
Share
  • Official Full Name
  • cytochrome P450, family 2, subfamily C, polypeptide 8
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
  • Synonyms
  • CYP2C8; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4 hydroxylase), polypeptide 8; cytochrome P450 2C8; CPC8; CYPIIC8; Cytochrome P450 family 2 subfamily C polypeptide 8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 subfamily IIC (mephenytoin 4 hydroxylase) polypeptide 8; Flavoprotein linked monooxygenase; Microsomal monooxygenase; MP 12/MP 20; P450 form 1; P450 IIC2; P450 MP 12/MP 20; S mephenytoin 4 hydroxylase; Xenobiotic monooxygenase; s-mephenytoin 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; MP-12/MP-20
Cat.#:CYP2C8-11773HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CYP2C8, His-tagged
+Inquiry
Cat.#:CYP2C8-120HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CYP2C8, GST-tagged
+Inquiry
Cat.#:CYP2C8-384HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CYP2C8
+Inquiry
Cat.#:CYP2C8-1150RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2C8 Protein, His-tagged
+Inquiry
Cat.#:CYP2C8-7114HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2C8 293 Cell Lysate
+Inquiry
Cat.#:Kit-0895Tag:
Source (Host):Species:
Product nameCYP2C8 Green Screening Kit
+Inquiry

Involved Pathway

CYP2C8 involved in several pathways and played different roles in them. We selected most pathways CYP2C8 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, CYP2E1 reactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2C8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CYP2Y3; CYP2V1; CYP2C70; CYP2P10; ALOX5A; PLA2G6; PLA2G4B; PLA2G4C; PLA2G10; PTGS2
Biological oxidations
SULT2ST1; CYP1A1; SULT1C2; ADH8A; CYP2K6; ADH7; DPEP2; UGT1B2; CYP2F1; UGT1B7
CYP2E1 reactions
CYP2A6; CYP2D6; CYP2F1; CYP2C8; CYP2C9; CYP2S1; CYP2A7; CYP2C19; CYP2E1; CYP2A13
Chemical carcinogenesis
GSTA4; PTGS2; MGST1; UGT1A9; GSTA5; UGT1A3; CHRNA7; FAM84B; CYP2A6; GSTO2
Cytochrome P450 - arranged by substrate type
CYP2W1; CYP11B1; CYP2Y3; CYP46A1; CYP4F22; CYP2K17; CYP26A1; CYP4A11; CYP2C9; CYP17A1
Drug metabolism - cytochrome P450
CYP2C19; GSTK1; GSTO2; ADH6; CYP2B6; ADH4; ADH1C; CYP2E1; ADH5; CYP2D6
Linoleic acid metabolism
PLA2G2A; CYP2C8; PLB1; CYP2C19; CYP3A41A; CYP2P6; PLA2G6; PLA2G4D; PLA2G3; PLA2G12B
Metabolic pathways
MAN2A1; IMPDH2; ALG3; MGAT1; ADI1; HEXA; CYP26A1; TPH1; ATP6V1B2; LYCAT

Protein Function

CYP2C8 has several biochemical functions, for example, (R)-limonene 6-monooxygenase activity, (S)-limonene 6-monooxygenase activity, (S)-limonene 7-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2C8 itself. We selected most functions CYP2C8 had, and list some proteins which have the same functions with CYP2C8. You can find most of the proteins on our site.
Function
Related Protein
Function (R)-limonene 6-monooxygenase activity
Related Protein CYP2C8; CYP2C19; CYP2C9
Function (S)-limonene 6-monooxygenase activity
Related Protein CYP2C19; CYP2C8; CYP2C9
Function (S)-limonene 7-monooxygenase activity
Related Protein CYP2C9; CYP2C8; CYP2C19
Function arachidonic acid epoxygenase activity
Related Protein CYP2AA9; CYP2AA1; CYP2A7; CYP2J2; CYP2C38; CYP2B19; CYP2AA12; CYP2AA4; CYP2J5; CYP2C39
Function enzyme binding
Related Protein UGT1A6A; NOTCH1; PTPLAD1; HSPA2; CTNNB1; TRP53; PTPLA; MAP2K7; TOP2A; SRC
Function heme binding
Related Protein CYP2C37; CYP19A1B; CYGB1; HBA2; ABCB6; MB; HBBE3; CYP4X1; CYP4F14; CYP2S1
Function iron ion binding
Related Protein HBA2; CYP2AD2; CYP20A1; HBAE1; CYP2D9; CYP4F12; CYP11B1; PDF; TPH1; ALOX15B
Function monooxygenase activity
Related Protein CYP2P7; CYP2P8; CYP2C8; CYP2P9; FOXRED2; CYP2D26; CYP2C70; CYP2P10; BCO1; CYP2K19
Function oxidoreductase activity
Related Protein DHRS13B; CYP1A1; CMAH; HSD11B1L; SNCA; HEPHL1A; GFOD1; DEGS2; ZADH2; QDPRB2
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2AA2; CYP2AD2; CYP2AA4; CYP2AD3; CYP2P7; CYP2AA6; CYP2K18; CYP2A13; CYP2X10.2; CYP2C50
Function oxygen binding
Related Protein CYP2K19; CYP2C54; CYP2C55; CBS; CYP1B1; HBE; CYP3A5; CYGB; CYP2C37; CYP2AD3
Function steroid hydroxylase activity
Related Protein CYP21A2; CYP2P7; CYP2C54; CYP2C19; CYP2D6; CYP2AA3; CYP2F1; CYP3A4; CYP2C55; CYP2P8

Interacting Protein

CYP2C8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2C8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2C8.
PGRMC1; A2M; APOE; DNAJB1; LONP1; BLMH; RIN3; MAST1; GABARAPL1; MAP1LC3A

CYP2C8 Related Articles

Jing, WH; Song, YL; et al. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 77:175-188(2013).
Davis, JA; Rock, DA; et al. In Vitro Characterization of the Drug-Drug Interaction Potential of Catabolites of Antibody-Maytansinoid Conjugates. DRUG METABOLISM AND DISPOSITION 40:1927-1934(2012).