cyp2r1
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  • Official Full Name
  • cytochrome P450, family 2, subfamily R, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.
  • Synonyms
  • CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1; vitamin D 25-hydroxylase; Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase; OTTHUMP00000231476; cytochrome P450, family 2, R1
Cat.#:CYP2R1-2269HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2R1 Protein, GST-tagged
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Cat.#:CYP2R1-1156RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2R1 Protein, His-tagged
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Cat.#:CYP2R1-7109HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2R1 293 Cell Lysate
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Involved Pathway

CYP2R1 involved in several pathways and played different roles in them. We selected most pathways CYP2R1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2R1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
CYP4A11; CYP2W1; UGT1B3; PAOX; ADH8B; CYP26A1; ADH1B; Sult2a6; GLYATL1; CYP2A13
Cytochrome P450 - arranged by substrate type
CYP2E1; CYP4A11; CYP4F12; CYP4B1; CYP1B1; CYP24A1; CYP3C1; CYP2K17; CYP2C18; CYP3A7
Metabolic pathways
SMS; AKR1B10; AGXT; DPAGT1; CYP21A2; OAT; AMY1A; GALNTL4; PIK3C2B; SUCLG2
Metabolism
APOBB.1; ELOVL1A; EBP; SLC44A5B; FTCD; AWAT2; ACMSD; CYP2K18; COQ6; CYP8B2
Metabolism of lipids and lipoproteins
LPA; ACOT11; MTP; ESRRA; ARF3; OSBP; NFYBB; GPAT2; FIG4; CDK19
Metabolism of steroid hormones and vitamin D
STARD5; CYP2R1; PPP1R2; GC; CYP24A1; HSD17B11; CYP27B1; AKR1B15
Phase 1 - Functionalization of compounds
CYP2K6; CYP3C1; CYP2R1; AADAC; CYP2W1; CYP2K18; CYP2Y3; CYP2K19; CYP2A7; CYP4F12
Steroid biosynthesis
SC5DL; CYP2R1; CEL.1; SOAT1; CELL; NSDHL; LSS; EBP; SC4MOL; FDFT1

Protein Function

CYP2R1 has several biochemical functions, for example, heme binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2R1 itself. We selected most functions CYP2R1 had, and list some proteins which have the same functions with CYP2R1. You can find most of the proteins on our site.
Function
Related Protein
Function heme binding
Related Protein HRG; CYP26A1; CYP2J6; MPO; PTGS1; CYP2U1; CYP11C1; CYP7A1; CYP4F14; CYP2K19
Function iron ion binding
Related Protein P3H2; CYP27A1; CYP2P9; CYP27B1; HBG2; CYP19A1; CALR; FA2H; CYP2AA6; CYP2C38
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2P7; CYP2X8; CYP2P10; CYP2X10.2; CYP2P9; CYP2C39; CYP2C19; CYP2J5; CYP2AD3; CYP2C18
Function oxygen binding
Related Protein HBE1; CYP2AD6; CYP2AA1; CYP2J6; CYP2K22; CYGB; CYGB2; CYP2R1; HBAD; CYP2X8
Function steroid hydroxylase activity
Related Protein CYP2X9; CYP2AA1; CYP2C9; CYP2K18; CYP2C54; CYP2J5; CYP2A4; CYP2C38; CYP2N13; CYP2AA12
Function vitamin D3 25-hydroxylase activity
Related Protein CYP2R1; CYP3A4; FAM84B; CYP27A1