CYP2R1 Protein, cytochrome P450, family 2, subfamily R, polypeptide 1


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Official Full Name cytochrome P450, family 2, subfamily R, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.
Synonyms CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1; vitamin D 25-hydroxylase; Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC; MGC4663; Vitamin D 25 hydroxylase; OTTHUMP00000231476; cytochrome P450, family 2, R1
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP2R1-2269H Recombinant Human CYP2R1 Protein, GST-tagged Wheat Germ GST
    Human CYP2R1-7109HCL Recombinant Human CYP2R1 293 Cell Lysate HEK293 N/A
    Rhesus Macaque CYP2R1-1156R Recombinant Rhesus monkey CYP2R1 Protein, His-tagged Mammalian Cell His

    CYP2R1 involved in several pathways and played different roles in them. We selected most pathways CYP2R1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations FDX1L; UGT1B7; CYP2S1; BPNT1; ADH1B; ACY3.2; GLYATL1; SLC26A1; CYP2C8; CYP2AD3
    Cytochrome P450 - arranged by substrate type CYP2K6; CYP26A1; CYP2J2; CYP2A7; CYP2F1; CYP2K16; CYP2A6; CYP3C1; CYP2W1; CYP2K17
    Metabolic pathways ACOT5; AK7B; NDUFB2; CYP2C55; PAFAH1B1A; MLYCD; MAT2A; RIMKLA; PIK3C2A; SPTLC2B
    Metabolism COX7C; ARF3; AKAP5; GLB1L; OAZ3; SLC25A32A; THEM5; MARCKSA; ACOT11A; ALOX5B.2
    Metabolism of lipids and lipoproteins CSNK1G2; ACSF2; INSIG2; G0S2; APOEB; ABHD4; APOA5; SGMS2; TMEM195; CPNE7
    Metabolism of steroid hormones and vitamin D HSD17B11; STARD5; CYP27B1; CYP2R1; GC; PPP1R2; AKR1B15; CYP24A1
    Phase 1 - Functionalization of compounds CYP2K19; CYP2K8; CYP8B2; CYP2N13; CYP2V1; CYP2K18; CYP2K17; CYP3C4; ADH8B; CYP2AD6
    Steroid biosynthesis Cel; SC5D; CYP51; CEL.1; LIPA; LSS; SOAT2; EBP; SC4MOL; FAXDC2

    CYP2R1 has several biochemical functions, for example, heme binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2R1 itself. We selected most functions CYP2R1 had, and list some proteins which have the same functions with CYP2R1. You can find most of the proteins on our site.

    Function Related Protein
    heme binding CYP4T8; BACH1; HBZ; CYP51; EPX; AMBP; CBS; NOS2; CYP4V7; CYP46A1.4
    iron ion binding CYP2C18; CYP4F12; CYP2AA3; HIF1AN; CYP2C19; CYP51; ALOX5B.3; TMLHE; CYP2AA4; FAXDC2
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2K19; CYP2C19; CYP1A; CYP2C38; CYP2K18; CYP2AA2; CYP2R1; CYP2A4; CYP2X7; CYP2D10
    oxygen binding HBBE2; CYP17A1; HBBE3; CYP4B1; HBAA1; CYGB; CYP2K19; CYP2P8; HBG2; CYP2D10
    steroid hydroxylase activity CYP2C8; CYP2AA3; CYP2A13; CYP2D10; CYP2C50; CYP2D26; CYP2B19; CYP46A1.2; CYP2C54; CYP2C19
    vitamin D3 25-hydroxylase activity CYP2R1; CYP3A4; FAM84B; CYP27A1

    CYP2R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2R1.

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