cyp2r1
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  • Official Full Name
  • cytochrome P450, family 2, subfamily R, polypeptide 1
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in this gene has been associated with selective 25-hydroxyvitamin D deficiency.
  • Synonyms
  • CYP2R1; cytochrome P450, family 2, subfamily R, polypeptide 1; vitamin D 25-hydroxylase; Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase; OTTHUMP00000231476; cytochrome P450, family 2, R1
Cat.#:CYP2R1-2269HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CYP2R1 Protein, GST-tagged
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Cat.#:CYP2R1-1156RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CYP2R1 Protein, His-tagged
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Cat.#:CYP2R1-7109HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CYP2R1 293 Cell Lysate
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Involved Pathway

CYP2R1 involved in several pathways and played different roles in them. We selected most pathways CYP2R1 participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
ACY3.2; CYP17A1; ADH4; ACY3; SLC26A1; CYP2C9; FDX1; UGT1B7; ADH8A; CYP3C1
Cytochrome P450 - arranged by substrate type
CYP4F11; CYP3A7-CYP3AP1; CYP4F22; CYP3A7; CYP2K18; CYP17A1; CYP2D6; CYP2B6; CYP11A1; CYP2U1
Metabolic pathways
CYP8B1; CTPS1A; B3GNT6; ALG9; MTMR6; COQ5; AOX1; ALDH1A3; GCH1; GAL3ST1A
Metabolism
PLCD3; CPTP; LOC100686744; DPYS; SULT2ST2; SLC35D1A; BCHE; ARL2; OSBP; PAICS
Metabolism of lipids and lipoproteins
LBR; THEM5; GLIPR1; CYP2U1; SLC25A1; ACOT9.2; Alb; APOC2; INSIG1; TPTE
Metabolism of steroid hormones and vitamin D
AKR1B15; GC; PPP1R2; HSD17B11; CYP27B1; STARD5; CYP24A1; CYP2R1
Phase 1 - Functionalization of compounds
AADAC; CYP2AD3; CYP2C18; CYP2K16; CYP3A7; CYP3C4; CYP2F1; CYP2U1; CES1; CYP2N13
Steroid biosynthesis
SQLE; FDFT1; SOAT2; TM7SF2; SC5DL; CYP51; MSMO1; CEL.1; CPN1; DHCR7

Protein Function

CYP2R1 has several biochemical functions, for example, heme binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2R1 itself. We selected most functions CYP2R1 had, and list some proteins which have the same functions with CYP2R1. You can find most of the proteins on our site.
Function
Related Protein
Function heme binding
Related Protein IDO1; HBBE2; CYP3A25; CYP2K19; CYP2AA9; CYP2P7; CYP3A5; HBM; CYP26A1; PTGIS
Function iron ion binding
Related Protein CYP2K22; CYP2K16; NDOR1; CYP17A2; CYP2D9; PLOD2; CYP1A2; FAM125B; PPEF1; P4HA1
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Related Protein CYP2P10; CYP2AD2; CYP2F1; CYP2R1; CYP2K16; CYP2C39; CYP1A; CYP2J5; CYP2AD6; CYP1D1
Function oxygen binding
Related Protein HBAD; CYP2AA1; CYP2K17; CYP2Y3; CYP2K22; HBM; HBB; HBQ1; CYP2B19; CYP2A12
Function steroid hydroxylase activity
Related Protein CYP46A1.4; CYP2W1; FAM84B; CYP2AA8; CYP46A1; CYP2K6; CYP2K22; CYP2K19; CYP21A2; CYP2X9
Function vitamin D3 25-hydroxylase activity
Related Protein CYP3A4; CYP2R1; CYP27A1; FAM84B