DDX20 Protein, DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

DDX20

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DDX20

Official Full Name DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Background The survival of motor neurons (SMN) gene is the disease gene of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The SMN protein is part of a complex containing several proteins, of which one, SIP1 (SMN interacting protein 1), has been characterized so far. The SMN complex is found in both the cytoplasm and in the nucleus, where it is concentrated in bodies called gems. In the cytoplasm, SMN and SIP1 interact with the Sm core proteins of spliceosomal small nuclear ribonucleoproteins (snRNPs), and they play a critical role in snRNP assembly. In the nucleus, SMN is required for premRNA splicing, likely by serving in the regeneration of snRNPs. A DEAD box putative RNA helicase, named Gemin 3 which is another component of the SMN complex, has been identified. Gemin 3 interacts directly with SMN, as well as with SmB, SmD2 and SmD3. Immunolocalization studies using mAbs to Gemin 3 show that it colocalizes with SMN in gems. Gemin 3 binds SMN via its unique COOHterminal domain, and SMN mutations found in some SMA patients strongly reduce this interaction. The presence of a DEAD box motif in Gemin 3 suggests that it may provide the catalytic activity that plays a critical role in the function of the SMN complex on RNPs.
Synonyms DDX20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20, 103kD; probable ATP-dependent RNA helicase DDX20; DP103; GEMIN3; gemin-3; DEAD box protein 20; component of gems 3; DEAD-box protein DP103; DEAD box protein DP 103; SMN-interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DKFZp434H052
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDX20-2472H Recombinant Human DDX20 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human DDX20-2471H Recombinant Human DDX20 Protein, GST-tagged Wheat Germ GST
    Human DDX20-7016HCL Recombinant Human DDX20 293 Cell Lysate HEK293 N/A
    Mouse DDX20-4404M Recombinant Mouse DDX20 Protein Mammalian Cell His
    Zebrafish DDX20-6695Z Recombinant Zebrafish DDX20 Mammalian Cell His

    DDX20 involved in several pathways and played different roles in them. We selected most pathways DDX20 participated on our site, such as Gene Expression, Metabolism of non-coding RNA, RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression ZNF550; PUS1; ZNF764; PEAK1; ZFP36L1A; NFIC; ZNF559; ZNF285A; SNAPC1B; COX16
    Metabolism of non-coding RNA SNUPN; DDX20; PRMT5; WDR77; CLNS1A; PEAK1
    RNA transport SARNP; EIF3JA; SMN1; XPO1; EEF1A1A; EIF2S1B; EEF1A2; CLNS1A; RPP38; SEC13
    mRNA processing SF3B2; CLK3; DDX20; HNRNPH2; PTBP2; LOC100862398; METTL3; PRPF4BB; HNRNPD; OASL2
    snRNP Assembly PEAK1; WDR77; CLNS1A; SNUPN; DDX20

    DDX20 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX20 itself. We selected most functions DDX20 had, and list some proteins which have the same functions with DDX20. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CDK6; IGHMBP2; SGK196; CAMK1DB; LANCL2; MYO5C; CSNK1A1L; AK2; EPHB4A; MCM3L
    ATP-dependent RNA helicase activity PL10; DDX27; SNRNP200; DDX6; DDX56; DDX10; DHX38; DDX19; FAM120B; DDX19A
    DNA binding SOX19A; PATZ1; POU3F2A; HOXA4; ZNF395; ZFP146; GLYR1; CERS5; ARID4A; HIST1H2AL
    histone deacetylase binding TRAF6; GLI3; MEF2B; HDAC6; HOXA10; ANKRA2; NR2E1; PRDM1; NACC2; MEF2A
    protein binding TRIM40; CREBBP; C19orf80; ASB13; DSN1; ARNTL1A; ANXA7; ARSI; ZMAT2; ALDH7A1
    protein binding, bridging CUX1; TRIM22; CAV2; FSCN1A; FSCN2A; FKBP4; DDX20; RBM14; NUFIP1; LOR
    protein domain specific binding CNTLN; HIST4H4; KCTD13; HIST1H4B; MTOR; TRP63; YWHAE2; HPCAL4; STX1B; E2F4
    repressing transcription factor binding HDAC7; NOC2L; MAGEA2; CTNNB1; TLE4; HDAC7A; HDAC9; HDAC1; EIF4E; MAGEA2B

    DDX20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX20 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX20.

    GEMIN4; SMN1; GEMIN5; MYC; HDAC11; PARP2

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