dtx1
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  • Official Full Name
  • deltex homolog 1 (Drosophila)
  • Background
  • Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.
  • Synonyms
  • DTX1; deltex homolog 1 (Drosophila); protein deltex-1; hDx 1; Deltex protein 1; Deltex-1; Deltex1; FXI-T1; Fxit 1; Fxit1; mDTX1; hDTX1; OTTHUMP00000241684; hDx-1
Cat.#:DTX1-2905HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DTX1 Protein, GST-tagged
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Cat.#:DTX1-1842HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DTX1 protein, His & T7-tagged
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Cat.#:DTX1-4856MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DTX1 Protein
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Cat.#:DTX1-6779ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DTX1
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Involved Pathway

DTX1 involved in several pathways and played different roles in them. We selected most pathways DTX1 participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
PSENEN; KAT2B; DLL1; DLK1; HER15.1; DTX2; DTX3L; TUBB3; RFNG; DVL1B

Protein Function

DTX1 has several biochemical functions, for example, Notch binding, SH3 domain binding, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DTX1 itself. We selected most functions DTX1 had, and list some proteins which have the same functions with DTX1. You can find most of the proteins on our site.
Function
Related Protein
Function Notch binding
Related Protein DTX1; DLL4; DLL3; JAG1B; SNW1; GALNT11; DNER; HIF1AN; JAG1A; EGFL7
Function SH3 domain binding
Related Protein SH3BP5; ARHGAP6; ITM2B; EFS; PLSCR4; CTTNBP2; ELMO1; SHANK1; QKI2; PLSCR3
Function UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
Related Protein LTN1; MARCH9; TMEM129; MARCH11; UBR1; RNF144AA; MARCH6; UBE2IB; RNF169; ITCHA
Function coenzyme F420-0 gamma-glutamyl ligase activity
Related Protein DTX1; MARCH5L; RFWD2; TRIM71; NEURL1B; SHRPRBCK1R; ZNRF2B; RNF144AB; SIAH1A; UBR1
Function coenzyme F420-2 alpha-glutamyl ligase activity
Related Protein LTN1; SHRPRBCK1R; NEURL3; RNF187; RNF169; TRIM41; SIAH2L; MUL1A; RAG1; ITCHA
Function ligase activity
Related Protein TRIM56; ZFP91; ITCH; RNF34; RNF181; E4F1; MARCH9; TRIM38; RNF170; RNF152
Function metal ion binding
Related Protein ZFP93; GALNT14; ASXL1; GLI3; ZFP14; PEG3; SCD5; ZNRF2A; TRIM35-30; SGSH
Function protein binding
Related Protein BTN2A2; RD3; ZNF433; TRIM55; TRIP4; MKKS; GOLGA3; ELMO3; DUSP14; CCDC42
Function protein-glutamic acid ligase activity
Related Protein RAG1; RNF169; MYLIPB; NEURL1B; ITCHA; MARCH9; MARCH11; MARCH4; RNF149; ZNRF3
Function protein-glycine ligase activity
Related Protein ITCHA; RNF144AB; MARCH5L; RNF144AA; RNF169; HERC2; RNF187; TRIM50; ZNRF3; RAG1
Function protein-glycine ligase activity, elongating
Related Protein ZNRF3; SHRPRBCK1R; MARCH4; SIAH1A; UBE2IB; MGRN1A; RFWD2; ARIH1L; MARCH9; MYLIPA
Function protein-glycine ligase activity, initiating
Related Protein TTLL3; MUL1A; HECW2; MARCH11; RNF187; UBE2IA; RFWD2; MARCH5L; MGRN1A; DTX1
Function ribosomal S6-glutamic acid ligase activity
Related Protein TMEM129; SHRPRBCK1R; UBE2M; RNF169; ZNRF3; RNF149; LTN1; MUL1A; G2E3; UBE2IB
Function tubulin-glutamic acid ligase activity
Related Protein ZNRF3; ARIH1L; SIAH2L; RNF144AB; ZNRF2B; NEURL1B; DTX1; ITCHA; TRIM50; UBE2IA
Function tubulin-glycine ligase activity
Related Protein RNF144AA; MYLIPB; G2E3; TRIM71; RC3H2; ZNRF2B; DTX1; ITCHA; MARCH11; HERC2
Function ubiquitin protein ligase binding
Related Protein TRAF4; BCL2; ACTG1; MAGEA2B; CALR; RAD18; GPR19; DERL1; UBE2R2; ATXN3
Function zinc ion binding
Related Protein USP33; GLO1; ADH7; NSMCE1; RNF122; FBXO11; RARG; SLU7; LHX2B; SPRYD5

DTX1 Related Articles

Aste-Amezaga, M; Zhang, NY; et al. Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors. PLOS ONE 5:-(2010).
Laycock, MV; Jellett, JF; et al. First report of a new rapid assay for diarrhetic shellfish poisoning toxins. HARMFUL ALGAE 5:74-78(2006).