dtx3l
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  • Official Full Name
  • deltex 3-like
  • Background
  • DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).
  • Synonyms
  • DTX3L; deltex 3-like (Drosophila); E3 ubiquitin-protein ligase DTX3L; BBAP; rhysin 2; rhysin2; rhysin-2; B-lymphoma- and BAL-associated protein
Cat.#:DTX3L-2909HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DTX3L Protein, GST-tagged
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Cat.#:DTX3L-12193HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DTX3L, GST-tagged
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Cat.#:DTX3L-4859MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DTX3L Protein
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Cat.#:DTX3L-6792HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DTX3L 293 Cell Lysate
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Involved Pathway

DTX3L involved in several pathways and played different roles in them. We selected most pathways DTX3L participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTX3L were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
Siglece; BLK; DYNC1LI2; KLRB1A; UBE2L6; KIF4A; AP2B1; KIF22; DYNC1I2; GRAP2B
Antigen processing: Ubiquitination &
UBR2; GAN; TPP2; TRIM41; ASB9; ASB2; TRIM69; SPSB2; RNF19B; BLMH
Proteasome degradation
RNF220; UBE2U; BLMH; SPSB2; RNF138; UBR2; IWS1; UFL1; STUB1; UBR1
Class I MHC mediated antigen processing &
UBR1; RBCK1; RNF19B; RNF220; ASB9; PJA2; RNF111; SPSB1; ASB2; SH3RF1
presentation
TRIM41; DZIP3; KLHL20; FBXO3; CYBB; CTSL2; BLMH; CTSL1; PJA2; WWP1
Immune System
IRF4; MICA; IGHM; RNF34; KIR2DS2; UBE2U; PIK3AP1; PAG1; IFIT11; MGC174152
Notch Signaling Pathway
JAG1B; JAG1A; RBPJL; RBPJA; APH1B; ADAM17; SNW1; HES1; NOTCH4; RBPJ

Protein Function

DTX3L has several biochemical functions, for example, histone binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DTX3L itself. We selected most functions DTX3L had, and list some proteins which have the same functions with DTX3L. You can find most of the proteins on our site.
Function
Related Protein
Function histone binding
Related Protein HIST1H47; DAXX; RBBP4; HINFP; ELP2; BRD7; ATAD2; HIST1H4I; COPRS; NCL
Function ligase activity
Related Protein WWP1; CBLL1; UBE2D1A; PELI2; RNF144AA; CDC34A; NAPRT1; PIAS2; UBE2KA; LIPT2
Function protein binding
Related Protein ZC3HC1; BAG6; CDH2; KLC1; HIPK4; ABCA1; FRA10AC1; KIF2C; MSI2; TMEM74
Function ubiquitin-protein transferase activity
Related Protein TRAF5; UBE2Q2; G2E3; MARCH2; TRIM13; RNF220; UBE3A; RNF151; RNF130; MUL1B
Function zinc ion binding
Related Protein RNF26; RFWD3; MMP7; TRIM35-7; RNF185; MARCH5; ZPR1; TRIM14; TRIM37; CBLB

Interacting Protein

DTX3L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTX3L here. Most of them are supplied by our site. Hope this information will be useful for your research of DTX3L.
SPG21; HIP2; UBE2D1; UBE2E1; UBE2D3; UBE2H; UBE2D2; UBE2I; RNF111; UBE2R2; UBE2E3; UBE2W; UBE2E2; PHF7; TRIM9; UBE2D4; MCM7

DTX3L Related Articles

Holleman, J; Marchese, A; et al. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. MOLECULAR BIOLOGY OF THE CELL 25:1892-1904(2014).
Bachmann, SB; Frommel, SC; et al. DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. MOLECULAR CANCER 13:-(2014).