dtx3l
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  • Official Full Name
  • deltex 3-like
  • Background
  • DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)).
  • Synonyms
  • DTX3L; deltex 3-like (Drosophila); E3 ubiquitin-protein ligase DTX3L; BBAP; rhysin 2; rhysin2; rhysin-2; B-lymphoma- and BAL-associated protein
Cat.#:DTX3L-2909HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DTX3L Protein, GST-tagged
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Cat.#:DTX3L-12193HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DTX3L, GST-tagged
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Cat.#:DTX3L-4859MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DTX3L Protein
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Cat.#:DTX3L-6792HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DTX3L 293 Cell Lysate
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Involved Pathway

DTX3L involved in several pathways and played different roles in them. We selected most pathways DTX3L participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTX3L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
LILRB1; PAG1; HUWE1; TRIM69; KIF2C; ASB17; CTS7; CD300LD; VPRBP; KIF11
Antigen processing: Ubiquitination &
UBE2J2; RNF182; VPRBP; SPSB4; RNF14; UBR2; KLHL21; ASB4; SPSB2; UBE2V2
Proteasome degradation
ASB10; RNF14; RNF19B; RNF34; TRIM50; ASB17; FBXO44; TPP2; GAN; ASB13
Class I MHC mediated antigen processing &
RNF34; RNF4; UBE2F; DZIP3; ASB7; UBR1; ASB9; ASB11; FBXO17; RNF182
presentation
KLHL20; CYBA; PJA2; SEC24A; FBXO27; UBE2V2; TRIM50; UBR2; HECTD3; CYBB
Immune System
DHX9; C1rb; RNF216; MB21D1; CASP4; ALCAMB; CRP; WWP1; KIF22; CD200R1
Notch Signaling Pathway
TLE3A; JAG1B; ADAM17A; LNX1; DLA; MFAP2; CNTN6; KAT2A; DTX4; DNER

Protein Function

DTX3L has several biochemical functions, for example, histone binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DTX3L itself. We selected most functions DTX3L had, and list some proteins which have the same functions with DTX3L. You can find most of the proteins on our site.
Function
Related Protein
Function histone binding
Related Protein HIST1H4B; HIST1H3C; ATAD2; PRKCBB; TBL1X; PRMT7; JAK2; RBBP4; HINFP; NCAPD2
Function ligase activity
Related Protein LIG4; RNF187; RNF133; TMEM129; EGR2; BIRC3; ADSSL; UBE2L3A; TTLL13; NEDD4L
Function protein binding
Related Protein EXOSC8; SYMPK; TBX15; IQCB1; VAPA; TLX1; CASP7; BICC1; DUSP12; PNKP
Function ubiquitin-protein transferase activity
Related Protein ITCH; PEX2; MALT1; UBE2B; RNF146; HECW2; RNF139; HACE1; PDZRN3; RLIM
Function zinc ion binding
Related Protein ZDHHC18A; SETDB1A; HE1B; ZCCHC2; RABGEF1; CBLL1; KDM5D; MAN2B2; RAI1; RNF4

Interacting Protein

DTX3L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTX3L here. Most of them are supplied by our site. Hope this information will be useful for your research of DTX3L.
SPG21; HIP2; UBE2D1; UBE2E1; UBE2D3; UBE2H; UBE2D2; UBE2I; RNF111; UBE2R2; UBE2E3; UBE2W; UBE2E2; PHF7; TRIM9; UBE2D4; MCM7

DTX3L Related Articles

Holleman, J; Marchese, A; et al. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. MOLECULAR BIOLOGY OF THE CELL 25:1892-1904(2014).
Bachmann, SB; Frommel, SC; et al. DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. MOLECULAR CANCER 13:-(2014).