dvl2
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  • Official Full Name
  • dishevelled, dsh homolog 2
  • Background
  • Dishevelled (Dsh) proteins are important intermediates of Wnt signaling pathways. Dsh inhibits glycogen synthase kinase-3beta promoting beta-catenin stabilization. Dsh proteins also participate in the planar cell polarity pathway by acting through JNK. Th
  • Synonyms
  • DVL2; dishevelled, dsh homolog 2 (Drosophila); dishevelled 2 (homologous to Drosophila dsh); segment polarity protein dishevelled homolog DVL-2; DSH homolog 2; dishevelled-2
Cat.#:DVL2-107HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DVL2, GST-tagged
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Cat.#:DVL2-108HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DVL2, GST-tagged
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Cat.#:DVL2-1844HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DVL2 protein, His-tagged
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Cat.#:DVL2-4900MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DVL2 Protein
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Cat.#:DVL2-1358RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DVL2 Protein, His-tagged
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Cat.#:DVL2-11925ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DVL2
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Cat.#:DVL2-6765HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DVL2 293 Cell Lysate
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Involved Pathway

DVL2 involved in several pathways and played different roles in them. We selected most pathways DVL2 participated on our site, such as Asymmetric localization of PCP proteins, Basal cell carcinoma, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DVL2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Asymmetric localization of PCP proteins
PRICKLE1B; PRICKLE1; DVL2
Basal cell carcinoma
HHIP; FZD1; WNT1; WNT3A; WNT7A; WNT11; GLI3; WNT7B; FZD5; WNT9A
Beta-catenin independent WNT signaling
AP2B1; MOV10; AP2A1; RYK; DVL2; DVL1; AP2M1; AGO3; CLTA; PRICKLE1B
Canonical Wnt signaling pathway
CSNK1E; DVL3; DVL1; CSNK1A1; KLHL12; CSNK1D; DVL2
DNA damage response (only ATM dependent)
MLKL; DVL1; DVL3; DVL2; BIK
Degradation of DVL
HECW1B; DACT1; DVL3; KLHL12; DVL2; DVL1; HECW1
Disassembly of the destruction complex and recruitment of AXIN to the membrane
CSNK1G2; WNT8-2; DVL2; DVL1; DVL3
HTLV-I infection
HLA-DQA2; POLE; DVL2; H2-AA; CALR; IL2RA; VDAC3; MAP3K1; PIK3R1; WNT3

Protein Function

DVL2 has several biochemical functions, for example, frizzled binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DVL2 itself. We selected most functions DVL2 had, and list some proteins which have the same functions with DVL2. You can find most of the proteins on our site.
Function
Related Protein
Function frizzled binding
Related Protein WNT2BA; DVL1B; FZD1; SFRP1; WNT7AA; NDP; RNF43; WNT2BB; WNT4A; ROR2
Function identical protein binding
Related Protein SLK; PRPF3; GAPDH; SERPINA1D; SMG9; ADIPOR1; TP53; SF1; PCM1; RASSF3
Function protein binding
Related Protein EMD; KDM6B; BRCA2; TIMM8A; CDC25C; MDH1; DUSP12; MRAP; CYGB; STX11
Function protein domain specific binding
Related Protein RQCD1; STMN3; CNTROB; NLRP1; TRP63; HIST1H4D; HIST1H4I; MYH9; SHROOM2; ARHGEF4
Function protein self-association
Related Protein MDH2; SHANK3; CTSC; TMEM190; PTH1R; TMEM43; PCSK9; PROSAPIP1; S100A7A; LDB1

Interacting Protein

DVL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DVL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DVL2.
DACT1; Smurf2; Pard6a

DVL2 Related Articles

Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
Ye, ZD; Zhang, CX; et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. NATURE COMMUNICATIONS 4:-(2013).