dsg2
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  • Official Full Name
  • desmoglein 2
  • Background
  • Desmoglein 2, also known as DSG2, is a human gene. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epitheli
  • Synonyms
  • DSG2; desmoglein 2; desmoglein-2; CDHF5; HDGC; cadherin family member 5; ARVC10; ARVD10; CMD1BB; MGC117034; MGC117036; MGC117037
Cat.#:DSG2-400HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSG2 Protein, His-tagged
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Cat.#:Dsg2-56MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dsg2 Protein
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Cat.#:DSG2-1601HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Desmoglein 2
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Cat.#:DSG2-512HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human DSG2, Fc Chimera
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Cat.#:Dsg2-41MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Dsg2, Fc-tagged
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Cat.#:DSG2-4842MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DSG2 Protein
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Cat.#:Dsg2-990MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Dsg2 Protein, Fc Chimera
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Cat.#:DSG2-6807HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human DSG2 293 Cell Lysate
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Involved Pathway

DSG2 involved in several pathways and played different roles in them. We selected most pathways DSG2 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
MYC; APAF1; CAPN2L; PANK1A; STK24A; MAP3K14; STK24B; IRF4A; E2F1; PIK3CA
Apoptotic cleavage of cell adhesion proteins
DSG2; DSG3; CTNNB2; PTBP3; OCLN; PKP1; DSP; DSG1; CTNNB1
Apoptotic cleavage of cellular proteins
DBNLB; LMNB1; CLSPN; PLECA; STK26; OCLN; BMX; SATB1; DSG3; PTBP3
Apoptotic execution phase
SATB1; ADD1; DSG3; CASP8L1; PLECA; CLSPN; HIST1H1E; BCAP31; LMNB1; DBNLA
Arrhythmogenic right ventricular cardiomyopathy
DMD; JUP; DAG1; DSC2; DSG2; DES; CDH2; CACNG3; CTNNA1; CACNG2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ACTN3; CACNG6; DSG2; CACNG4; GJA1; DES; TCF7; ACTN1; ACTN4; ITGB4
Programmed Cell Death
STK24B; HMGB2A; STK26; PLECA; DIABLOA; DAPK1; PANK1A; RIPK3; DBNLB; BMX

Protein Function

DSG2 has several biochemical functions, for example, calcium ion binding, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication. Some of the functions are cooperated with other proteins, some of the functions could acted by DSG2 itself. We selected most functions DSG2 had, and list some proteins which have the same functions with DSG2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CAPN8; ACTN3B; CAPN3; RHOT1; CDH11; PADI4; CASQ2; NINL; TC2N; F7
Function cell adhesion molecule binding
Related Protein CADM2A; PVRL1A; NPTN; NRXN2; Fert2; SELL; CD1d1; ITGA4; GLYCAM1; CADM2
Function cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Related Protein CTNNA3; DSC2; JUP; PKP2; DSP; DSG2

Interacting Protein

DSG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSG2.
ganglioside_gm1; JUP; Cbx1; DSC2; Trim69; Flot1; PDGFRA; FLNA; MYH9; Bmpr1a; IQGAP1; Tpm1; Actb; ACTR2; Ppp1cb; Jup; DBN1

DSG2 Related Articles

Espana, A; Koga, H; et al. Antibodies to the amino-terminal domain of desmoglein 1 are retained during transition from pemphigus vulgaris to pemphigus foliaceus. EUROPEAN JOURNAL OF DERMATOLOGY 24:174-179(2014).
Toumi, A; Saleh, MA; et al. Autoimmune reactivity against precursor form of desmoglein 1 in healthy Tunisians in the area of endemic pemphigus foliaceus. JOURNAL OF DERMATOLOGICAL SCIENCE 70:19-25(2013).