e2f4
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  • Official Full Name
  • E2F transcription factor 4, p107/p130-binding
  • Background
  • The E2F family of transcrIPPtion factors regulates gene expression following heterodimerization with the DP family proteins, which promote transition to S phase from G1 phase. E2F activity is controlled by interactions with the retinoblastoma tumor suppre
  • Synonyms
  • E2F4; E2F transcription factor 4, p107/p130-binding; transcription factor E2F4; E2F 4; p107/p130-binding protein; E2F-4
Cat.#:E2F4-3008HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human E2F4 Protein, GST-tagged
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Cat.#:E2F4-12248HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human E2F4, GST-tagged
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Cat.#:E2F4-4933MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse E2F4 Protein
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Cat.#:E2F4-1367RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey E2F4 Protein, His-tagged
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Cat.#:E2F4-1270CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken E2F4
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Cat.#:E2F4-12603ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish E2F4
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Cat.#:E2F4-6741HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human E2F4 293 Cell Lysate
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Cat.#:Kit-0318Tag:
Source (Host):Species:
Product nameE2F4 Gene Knockdown Quantification Kit
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Involved Pathway

E2F4 involved in several pathways and played different roles in them. We selected most pathways E2F4 participated on our site, such as Adipogenesis, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adipogenesis
GTF3AA; AGPAT2; SMAD3B; KLF6A; CEBPB; CNTFR; CELF1; DVL1; KLF7A; SPOCK1
Cell Cycle
VRK1; DSN1; RAD21A; TTK; RAD1; YWHAG; LIN9; MAD2L1; CDC14B; CDC25A
Cell Cycle, Mitotic
ACTR1A; CDK11B; MYBL2; NCAPG2; PIANP; NIPBL; NUP35; E2F2; DYNC1H1; SPDL1
Cyclin D associated events in G1
CDK7; PIANP; CDKN2B; CKS1B; E2F4; CDKN2C; CDKN2D
E2F transcription factor network
CES3; HIC1; CDKN2C; HBP1; DHFR; CES5A; CES1; SMARCA2; MYBL2; TRIM28
G0 and Early G1
LIN37; E2F4; MYBL2; LIN9; LIN52; PIANP; DYRK1A; TOP2A; LIN54
G1 Phase
CDKN2D; E2F4; CDKN2C; PIANP; CKS1B; CDKN2B

Protein Function

E2F4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F4 itself. We selected most functions E2F4 had, and list some proteins which have the same functions with E2F4. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein UBN2; ZBTB18; RXRA; DLX3B; ZBP1; PSMC3IP; PPARG; HMGXB4; MXI1; TOX
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein KCNA3; SOX10; SP1; ZNF100; HNRNPC; MYF6; NFYC; KDM6A; NR1D1; RBPJA
Function protein binding
Related Protein SMO; ZBTB32; ATP1B2; RABAC1; TIPRL; MPZL1L; LAMA1; TRAPPC10; COLGALT2; RCAN1
Function protein domain specific binding
Related Protein HIST1H4L; HIST1H4J; PHRF1; STX1A; WNT3; DBNL; WNT1; KCTD13; WHRN; CA
Function transcription factor activity, sequence-specific DNA binding
Related Protein LHX8A; RNF4; PRDM15; HNF1B; CBL; ZNF567; ARNT2; TBX5; NFE2L1B; ELK4
Function transcription factor binding
Related Protein IRF4; RNF222; BCL3; MSX2; CEBPB; SOX10; NKX2; ARID5A; Ar; SRY
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NFAT5; ELK3; NPAS4; NKX2-8; NR1H4; NEUROD6; MITFA; HOXD13; MYOG; CTCFL

Interacting Protein

E2F4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F4 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F4.
RBL2; TFDP2; LIN9; RB1; E7; MYBL2; RBL1; TFDP1

E2F4 Related Articles

Demyanenko, SV; Uzdensky, AB; et al. PDT-induced epigenetic changes in the mouse cerebral cortex: A protein microarray study. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840:262-270(2014).
Yin, D; Xie, D; et al. DLK1: increased expression in gliomas and associated with oncogenic activities. ONCOGENE 25:1852-1861(2006).