E2F4
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Official Full Name
E2F transcription factor 4, p107/p130-binding
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Overview
The E2F family of transcrIPPtion factors regulates gene expression following heterodimerization with the DP family proteins, which promote transition to S phase from G1 phase. E2F activity is controlled by interactions with the retinoblastoma tumor suppre -
Synonyms
E2F4; E2F transcription factor 4, p107/p130-binding; transcription factor E2F4; E2F 4; p107/p130-binding protein; E2F-4;
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E2F4 involved in several pathways and played different roles in them. We selected most pathways E2F4 participated on our site, such as Adipogenesis, Cell Cycle, Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipogenesis | CELF1;PLIN2;CEBPA;NAMPT;GATA2A;KLF6;SPOCK1;NDN;NCOA2 |
| Cell Cycle | CENPQ;DKC1;CKAP5;SMAD3B;RAD17;TSGA14;NDC80;MYCA;SUN1 |
| Cell Cycle, Mitotic | CEP164;HIST3H2BB;TUBB4B;TUBG2;CENPP;DPF1;ERCC6L;CDK11B;TUBGCP2 |
| Cyclin D associated events in G1 | CDKN2B;CKS1B;PIANP;CDK7;CDKN2D;CDKN2C;E2F4 |
| E2F transcription factor network | E2F4;RYBP;RBBP8;HIC1;TRIM28;CES5A;E2F6;SMARCA2;PRMT5 |
| G0 and Early G1 | LIN37;PIANP;LIN54;DYRK1A;LIN52;TOP2A;LIN9;E2F4;MYBL2 |
| G1 Phase | CKS1B;CDKN2D;PIANP;CDKN2C;CDKN2B;E2F4 |
E2F4 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F4 itself. We selected most functions E2F4 had, and list some proteins which have the same functions with E2F4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | RARGA;CDT1;SETDB2;POU2F1B;DMRT3;CERS2;KCNH7;TRAF4;CTCFL |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NR2C1;NFYC;NFKB2;NFE2L3;ZNF502;FOXI1;TFAP2A;NFIA;MYBL1 |
| protein binding | SUMO3;MRPL20;MINK1;SYVN1;CINP;GRM1;COASY;EPB41L1;KCNQ1 |
| protein domain specific binding | DIXDC1;SORBS2;NDE1;CALM1;YWHABB;MECP2;CENPJ;VPS4A;ICA1L |
| transcription factor activity, sequence-specific DNA binding | UBN2A;HMGB1;SPZ1;ZNF37A;SCAND1;FOXP3;SOX6;RORB;MTA2 |
| transcription factor binding | E2F5;SOST;DR1;CDK9;FLNA;LEF1;TWIST1;DDIT3;NAB1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PITX3;FOXC2;STK16;MIXL1;JUNB;RBPJ;HEYL;POU4F3;CREB3L1 |
E2F4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F4 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F4.
RBL2; TFDP2; LIN9; RB1; E7; MYBL2; RBL1; TFDP1
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